1,720,992 research outputs found
Usp21 deubiquitinase regulates aim2 inflammasome activation
No full text© 2021 by TheAmericanAssociation of Immunologists, Inc.Innate immune sensing of cytosolic DNA via absent in melanoma 2 (AIM2) is a key mechanism leading to inflammatory responses. As aberrant immune responses by dysregulated AIM2 are associated with autoinflammatory diseases, activation of the AIM2 inflammasome should be tightly controlled. In this study, we discovered that ubiquitination and deubiquitination of AIM2 are critical events that regulate AIM2 inflammasome activation. In resting human macrophage cells, AIM2 is constitutively ubiquitinated and undergoes proteasomal degradation to avoid autoinflammation. Upon DNA stimulation, USP21 binds to AIM2 and deubiquitinates it, thereby increasing its protein stability. In addition to the role of USP21 in regulating AIM2 turnover, we uncovered that USP21-mediated deubiquitination of AIM2 is required for the assembly of the AIM2 inflammasome. Depletion of USP21 does not affect the DNA-binding ability of AIM2 but inhibits the formation of the AIM2-ASC complex. Our findings establish that fine-tuning of AIM2 by the ubiquitin system is important for regulating AIM2 inflammasome activation.11Nsciescopu
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Improvement of GTTI Using non-Parametric Approach and Water Breakthrough Time Prediction
Full text link학위논문 (석사)-- 서울대학교 대학원 : 에너지시스템공학부, 2014. 8. 최종근.저류층특성화와 불확실성 정량화는, 유전개발과정 상의 의사결정을 위한 필수 과정이다. 초기에 제한된 정보를 바탕으로 구축된 저류층 모델은 큰 불확실성을 가진다. 따라서 추가적으로 획득한 동적자료를 결합하여 불확실 성을 줄이는 저류층특성화를 실시한다. 이를 통해 다양한 등가의 모델을 구축하고 불확실성을 분석하는 것을 불확실성 정량화라고 한다. 불확실성 정량화는 다수의 모델을 계산하며 각 모델에 대한 최적화 과정에 많은 계산량이 필요하므로 GTTI(generalized travel time inversion)와 같은 유선 시뮬레이션 기반 역산을 활용할 수 있다.
불확실성 정량화를 효과적으로 수행하기 위해서는 역산에서 도출되는 다수의 모델들이 실제 필드를 잘 대표할 수 있어야 한다. 하지만 GTTI는 실제 필드의 물성치가 강한 비정규성을 가지면 필드의 물성치 분포를 바르게 예측하지 못한다. 또한 GTTI는 기법 상의 한계로 인해 물 돌파가 발생하지 않은 유정들에 대해서는 역산을 수행할 수 없다. 따라서 이러한 경우들에 GTTI로 구축된 모델들은 실제 필드를 대표하지 못하므로, 불확실성 정량화 결과도 올바르지 않다.
본 연구에서는 GTTI 기법의 이러한 한계를 비모수접근법과 물 돌파시간 예측을 통해 극복하고자 하였다. 비모수접근법과 정규스코어변환을 활용함으 로써 물성치가 강한 비정규성을 갖는 경우에 대한 물성치분포 예측성능을 높였다. 또한 아직 물 돌파가 나타나지 않은 유정들의 물 돌파시간을 예측 하고, 역산과정에서 각 유정별로 예측된 물 돌파시간을 반영하였다. 이를 통해 해당 유정들에서 아직 물 돌파가 나타나지 않았다는 정보를 온전히 활용하고 불확실성을 최소화하였다. 본 연구에서 개선된 GTTI를 활용한 결과, 앞서 언급한 상황들에서 실제 필드를 보다 잘 대표하는 모델들을 구축하고 불확실성 정량화를 효과적으로 수행할 수 있었다.초 록 i
List of Tables iii
List of Figures iv
1. 서 론 1
2. 이론적 배경 6
2.1 유선시뮬레이션 6
2.2 GTTI(generalized travel time inversion) 기법 14
2.3 GTTI 기법이 갖는 한계 27
2.4 비모수접근법 29
2.5 임의최대가능도추정법 32
3. 비모수접근법과 물 돌파시간 예측을 이용한 GTTI 기법의 개선 34
3.1 비모수접근법을 적용한 GTTI 34
3.2 예측 물 돌파시간을 적용한 GTTI 38
4. 연구결과 42
4.1 참조필드의 설정 42
4.2 이중최빈값 분포 초기 앙상블 생성 52
4.3 비모수접근법 적용이 특성화 결과에 미치는 영향 57
4.4 예측 물 돌파시간 적용이 특성화 결과에 미치는 영향 78
5. 결 론 96
참고 문헌 100
ABSTRACT 105Maste
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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