179 research outputs found
Wykładanie przedmiotów prawniczych — typowe problemy wykładowcy
No full textThe author deals with problems with which lecturer of legal subjects meets (especially during the first years of studies i.e. lecturing for first-year students). The article (presentation for the conference: Law as an interdisciplinary phenomenon, 22 May 2018, GSW, Gdańsk) is written primarily on the basis of our own experience. The author considers the following problems to be particularly serious: lowering the level of teaching in secondary schools (especially history and Polish language), specific legal terminology, low quality of law in Poland, over-reliance on sources available on the Internet.Autor zajmuje się problemami, z którymi spotyka się wykładowca przedmiotów prawniczych, szczególnie na pierwszych latach studiów. Artykuł (referat) jest napisany przede wszystkim na podstawie własnych doświadczeń. Za szczególne problemy autor uważa: obniżenie poziomu nauczania w szkołach średnich (szczególnie historii i języka polskiego), specyficzną terminologię prawniczą, niską jakość prawa w Polsce, nadmiernie poleganie na źródłach dostępnych w Internecie
Immunohistochemical markers, are we having too many choices?
No full textAs more and more antibodies are made available for immunohistochemical studies, pathologists are
increasing being challenged to make a rational choice from multiple antibodies all of which are reputably
suited for the same or similar diagnostic application. A recent review was conducted into the practice
of a group of histopathologists working in a general teaching hospital in how they had used the three
antibodies, namely smooth muscle actin, calponin and p63, each of which could be used as a marker for
myoepithelial differentiation. The findings are presented and discussed. Immunohistochemical studies
recently carried out in the histopathology laboratory of the Queen Mary Hospital, Hong Kong were
recorded in a computerized database. The database was searched for all stains performed for actin,
calponin, and p63 from Jan 2005 to the end of April 2007. Parameters selected were the accession
number complete with the tissue block number, antibodies stained and the pathologist ordering the
stains. A total of 1148 blocks were stained for actin (n=803), calponin (n=127), and p63 (n=574).
Pathologists varied widely in their choice of applying these antibodies. While it is uncommon to use
all 3 antibodies on a single block (n=38), one pathologist alone was responsible for 76% (n=29) of this
usage. Slightly more blocks were stained for p63 alone (n=291) then those stained in combinations
with actin and/or calponin (n=283). Significant variation in the use of the 3 antibodies was observed
among a group of 24 pathologists working in a single public institution. Stereotypic patterns of
applying immunohistochemical stains may result in excessive procedures. A system to monitor and
provide timely feedback on the usage of immunohistochemical markers with the adoption of common
protocols would effect cost cuts and more efficient running of laboratory services.link_to_subscribed_fulltex
Images in pathology: the many faces of hepatocellular carcinoma
No full textlink_to_subscribed_fulltex
Glomerular pathology of allograft kidneys
No full textBackground: To review glomerular diseases diagnosed in
allograft kidneys and to correlate them with clinical parameters.
Methods: Eight hundred and ninety-one renal graft biopsies
and 43 graft nephrectomies filed in Queen Mary Hospital from
1980 to 2004 were studied. They came from 442 allografts
transplanted to 425 patients. Results: Glomerular diseases were
diagnosed in 33.0% of kidney grafts. Indications for biopsy
were baseline assessment (23 biopsies, 2.5%), renal dysfunction
(790 biopsies, 88.7%), proteinuria (154 biopsies, 17.3%),
hematuria (11 biopsies, 1.2%), and by protocol (4 biopsies,
0.4%). The median time post-transplant when the biopsies were
procured was less than 8 months. The mean time posttransplant
for diagnosing IgA nephropathy (IgAN), transplant
glomerulopathy (TG), focal segmental glomerulosclerosis
(FSG), mesangiocapillary glomerulonephritis (MCGN),
membranous GN, mesangial proliferative GN, and diabetic
nephropathy was 70, 66, 65, 55, 45, 49, and 101 months,
respectively. Specific glomerular diseases were diagnosed by
biopsies in 106 of 119 (89.1%) proteinuric allografts. Recurrent
glomerular disease was documented in 31 (7.0%) grafts.
Conclusion: Glomerulopathy was common in allograft biopsies.
IgAN, TG, FSG, mesangial proliferative GN, and membranous
GN comprised the majority. A higher proportion of grafts from
donors related to the recipients than from unrelated donors had
IgAN (p < 0.05), and there was no difference in the time to
diagnose IgAN post-transplant between the two groups,
suggesting that genetic factors might play a role in its
pathogenesis. Recurrence of glomerulopathy underlying endstage
renal disease was frequent for IgAN, FSG, and MCGN,
but this was rare for membranous GN
Generalized spike-wave discharges involve a default mode network in patients with juvenile absence epilepsy : A MEG study
No full textThis study uses magnetoencephalography (MEG) to examine whether cortical regions that constitute a default mode network are involved during generalized spike-wave discharges (GSWs) in patients with juvenile absence epilepsy (JAE). We studied five JAE patients for whom MEG was recorded using a 204-channel, whole-head gradiometer system. Dynamic statistical parametric mapping (dSPM) was done to estimate the cortical source distribution of GSW. The dSPM results showed strong medial prefrontal activation in all patients, with activation in the posterior cingulate and precuneus in three of five patients simultaneously or slightly after medial prefrontal activation. Furthermore, dSPM showed that the initial activation of a GSW appears in the focal cortical regions. Cortical regions that constitute a default mode network are strongly involved in the GSW process in some patients with JAE. Results also show that focal cortical activation appears at the onset of a GSW
Assessing Usable Ground and Surface Water Level Correlation Factors in the Western United States
No full textabstract: The Western Continental United States has a rapidly changing and complex ecosystem that provides valuable resources to a large portion of the nation. Changes in social and environmental factors have been observed to be significantly correlated to usable ground and surface water levels. The assessment of water level changes and their influences on a semi-national level is needed to support planning and decision making for water resource management at local levels. Although many studies have been done in Ground and Surface Water (GSW) trend analysis, very few have attempted determine correlations with other factors. The number of studies done on correlation factors at a semi-national scale and near decadal temporal scale is even fewer. In this study, freshwater resources in GSW changes from 2004 to 2017 were quantified and used to determine if and how environmental and social variables are related to GSW changes using publicly available remotely sensed and census data. Results indicate that mean annual changes of GSW of the study period are significantly correlated with LULC changes related to deforestation, urbanization, environmental trends, as well as social variables. Further analysis indicates a strong correlation in the rate of change of GSW to LULC changes related to deforestation, environmental trends, as well as social variables. GSW slope trend analysis also reveals a negative trend in California, New Mexico, Arizona, and Nevada. Whereas a positive GSW trend is evident in the northeast part of the study area. GSW trends were found to be somewhat consistent in the states of Utah, Idaho, and Colorado, implying that there was no GSW changes over time in these states.Dissertation/ThesisMasters Thesis Geography 201
Glomerular pathology of allograft kidneys in Hong Kong
No full textAims. Our goal was to define the spectrum of glomerular diseases in allograft kidneys and to correlate them with clinical parameters. Methods. Eight hundred ninety-one renal graft biopsies and 43 graft nephrectomies from 1980 to 2004 were obtained from 442 allografts transplanted to 425 patients. Results. Glomerular diseases were diagnosed in 33% of kidney grafts. Indications for biopsy were baseline assessment (23 biopsies, 2.5%); renal dysfunction (790 biopsies, 88.7%); proteinuria (154 biopsies, 17.3%); hematuria (11 biopsies, 1.2%); and study protocol (four biopsies, 0.4%). The median time to take a biopsy was less than 8 months posttransplant. The mean time posttransplant when the biopsy diagnosis was made was 70 months for IgA nephropathy (IgAN); 66 months for transplant glomerulopathy (TG); 65 months for focal segmental glomerulosclerosis (FSG); 55 months for mesangiocapillary glomerulonephritis (MCGN); 45 months for membranous glomerulonephritis (GN); 49 months for mesangial proliferative GN; and 101 months for diabetic nephropathy. Recurrent glomerular disease was documented in 31 (7.0%) grafts. Specific glomerular diseases were diagnosed by biopsies in 106 (89.1%) of 119 proteinuric allografts. Conclusions. Glomerulopathy was common in allografted kidneys. IgAN, TG, FSG, mesangial proliferative GN, and membranous GN were the majority. A higher proportion of grafts from donors related to the recipients than from unrelated donors showed IgAN (P < .05), suggesting that genetic factors might play a role in the pathogenesis of IgAN. Recurrence of glomerulopathy underlying ESRD was frequent for IgAN, FSG, and MCGN, but this was rarely seen in membranous GN. © 2005 by Elsevier Inc. All rights reserved.link_to_subscribed_fulltex
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