636 research outputs found
A Novel Neuropsychiatric Phenotype of Kcnj2 Mutation in One Taiwanese Family with Andersen-Tawil Syndrome
No full textTawil syndrome (ATS) is a rare familial potassium channelopathy characterized by the clinical triad of periodic paralysis, cardiac arrhythmia and dysmorphic facial /skeletal features. The majority of ATS patients are caused by mutations of the KCNJ2 gene, which encodes the inward- rectifying potassium channel protein Kir2.1. However, the effects of the KCNJ2 mutation on the central nervous system are rarely studied. In this report, we describe a heterozygous missense mutation (p.Thr192Ile) in the KCNJ2 gene, which segregates with the disease phenotype in an ATS family. It is noted that in addition to the classical clinical phenotypes of ATS, the index patient exhibited major depression and pyramidal tract signs with diffuse periventricular white matter lesions without contrast enhancement. This mutation and the unusual clinical manifestations observed underscore the phenotypic complexity underlying ATS. Our observations expand the current knowledge of the phenotypic variability of ATS caused by the KCNJ2 mutation. Patients with ATS, especially those carrying the KCNJ2 mutations, should be monitored for their potential neuropsychiatric system involvement
() Simplified diagram of steps required for glass functionalization with amino (ATS) and carboxyl (BTA) groups
No full text<p><b>Copyright information:</b></p><p>Taken from "BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies"</p><p>Nucleic Acids Research 2006;34(3):e22-e22.</p><p>Published online 9 Feb 2006</p><p>PMCID:PMC1363783.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> Staining of derivatized glass surfaces using NBD reagents of () aminated (ATS) and () carboxylated (BTA) glass slides
Rancang Bangun Automatic Transfer Switch (ATS)
No full textThe existence of electrical energy is already something of a primary
need in modern human life so that almost all people rely on electricity supply
from PLN. It can not be denied that the availability of electrical energy from PLN
can be guaranteed 100%, many obstacles that cause cessation of electricity
supply to consumers. Both the system generator and the distribution network
system, Based on the above background, the author tries to create a system that
can provide the needs in electrical energy. With the hope of this system can be
useful for the public umum.Pembuatan ATS This Has been done for 4 months in
the Department of Electrical Engineering is the focus of the discussion is ATS.
ATS and AMF will release the supply to the load when the voltage is in the normal
state of 220 volts, and release to the load when the generating frequency is in the
normal state of 50 Hz, and the time required by the genset to supply the load after
the starting is 60 seconds Genset will stop working
Earth-satellite propagation above GHz: Papers from the 1972 spring URSI session on experiments utilizing the ATS-5 satellite
No full textPapers are reported from the Special Session on Earth-Satellite Propagation Above 10 GHz, presented at The 1972 Spring Meeting of the United States National Committee, International Union of Radio Science, April 1972, Washington, D. C. This session was devoted to propagation measurements associated with the Applications Technology Satellite (ATS-5), which provided the first operational earth-space links at frequencies above 15 GHz. A comprehensive summary is presented of the major results of the ATS-5 experiment measurements and related radiometric, radar and meteorological studies. The papers are organized around seven selected areas of interest, with the results of the various investigators combined into a single paper presented by a principal author for that area. A comprehensive report is provided on the results of the ATS-5 satellite to earth transmissions. A complete list of published reports and presentations related to the ATS-5 Millimeter Wave Experiment is included
INDONESIA AIR TRAFFIC SERVICES (ATS) READINESS AND STRATEGIC PLANS FOR TAKING OVER AIRSPACE AND IMPROVING THE SERVICE : CASE STUDY : AIRSPACE SECTOR A, B, AND C
No full text Indonesia is trying to take over airspace Sector A, B, and C from Singapore and this desire has been going on for decades. To carry out these dreams, Indonesia was faced with a series of agreements with Singapore and Malaysia because both countries have interests in that airspace sector. To take over that airspace, Indonesia must perform a series of efforts. One of the efforts is by improving Air Traffic Services (ATS) quality in Indonesia. In determining ATS service quality, pilot perceiving and expectation must be assessed. Pilot employed tangible and intangible cues to determine the quality. The author determined forty items to describe pilot perception and expectation based on 10 (ten) criteria in evaluating service quality. Moreover, total ATS quality which is including technical quality and functional quality dimensions are clearly presented. Other factor influencing ATS quality is safety culture which is merged with ATS quality. Human factor as the main source in conducting service is described clearly in relation with ATS. Human factor become important because human and its environment can affect ATS performance. Six principles of service management are elaborated in ATS system to improve ATS quality. Combined with service and management theories to obtain the conclusion of Indonesia ATS quality and ATS readiness, this research discussed the Indonesia strategic plan to improve service quality. Then, Directorate General of Civil Aviation (DGCA) will work together with Indonesia ANSP and ATS Unit authority to manage ATS quality in Indonesia in order to taking over airspace Sector A, B, and C from Singapore.Transportation Researc
Is exercise training safe and effective for ALL heart failure patients: A retrospective service evaluation of a hospital based cardiac rehabilitation programme
No full textThe main purpose of this study was to investigate whether exercise training is safe and effective for all classifications of heart failure, female and elderly (70 years and above) heart failure patients and also those heart failure patients with significant co-morbidity. Much of the research into exercise training and heart failure has been carried out on middle aged men in NYHA II-III classification of heart failure who have no other significant co-existing conditions. This is not reflective of the population of heart failure patients in general. The cardiac rehabilitation records (n=1000) of heart failure patients who had attended an exercise programme at a hospital based NHS service over a period of ten years were retrospectively evaluated to investigate the safety and efficacy of exercise training. Analysis of baseline statistics and repeated outcome measures were used to investigate the significance of the service and to ascertain where similarities and differences lay with the research. 74% were male, the age range was 17-90 years and 52% of patients had one or more significant co-morbidity. The acute event incidence was recorded at four per 1000 patients. NYHA I patients, female, elderly heart failure patients and those with significant co-morbidity showed significant improvements in functional capacity and quality of life measures with exercise training (p< 0.05). However no conclusion on the effectiveness of exercise could be drawn for NYHA IV heart failure patients due to insufficient recorded data and reduced adherence to exercise sessions for this group. A hospital based exercise programme, therefore may not be the most appropriate setting for the NYHA IV patient. This study supports previous research of the benefit of exercise training in heart failure but broadens it further to show that exercise is safe for all heart failure patients and is also effective for all heart failure patients with the exception of NYHA IV patients where further investigation is needed
Yield of DNA attachment using different cross-linkers between aminated slides (ATS) and modified oligonucleotides
No full text<p><b>Copyright information:</b></p><p>Taken from "BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies"</p><p>Nucleic Acids Research 2006;34(3):e22-e22.</p><p>Published online 9 Feb 2006</p><p>PMCID:PMC1363783.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> Experiment is performed in one glass channel chip. The channels differ by the cross-linker used: First 3 channels are treated with s-MBS. Channels 4 to 6 are treated with TMA and 7–8 with BTA. The surfaces are then grafted and hybridized with the appropriate DNA material (see text for grafting and hybridization conditions)
Prevalence of airflow limitation in outpatients with cardiovascular diseases in Japan
No full textKatsuya Onishi,1 Daisuke Yoshimoto,2 Gerry W Hagan,3 Paul W Jones4 1Onishi Heart Clinic, Mie, 2Medical Affairs Respiratory, GlaxoSmithKline KK, Tokyo, Japan; 3Independent Consultant, Marbella, Spain; 4Division of Clinical Science, St George's, University of London, London, UK Background and objectives: Cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD) commonly coexist and share common risk factors. The prevalence of COPD in outpatients with a smoking history and CVD in Japan is unknown. The aim of this study was to determine the proportion of Japanese patients with a smoking history being treated for CVD who have concurrent airflow limitation compatible with COPD. A secondary objective was to test whether the usage of lung function tests performed in the clinic influenced the diagnosis rate of COPD in the patients identified with airflow limitation. Methods: In a multicenter observational prospective study conducted at 17 centers across Japan, the prevalence of airflow limitation compatible with COPD (defined as forced expiratory volume (FEV)1/FEV6 <0.73, by handheld spirometry) was investigated in cardiac outpatients ≥40 years old with a smoking history who routinely visited the clinic for their CVD. Each patient completed the COPD Assessment Test prior to spirometry testing. Results: Data were available for 995 patients with a mean age of 66.6±10.0 years, of whom 95.5% were male. The prevalence of airflow limitation compatible with COPD was 27.0% (n=269), and 87.7% of those patients (n=236) did not have a prior diagnosis of COPD. The prevalence of previously diagnosed airflow limitation was higher in sites with higher usage of lung function testing (14.0%, 15.2% respectively) compared against sites where it is performed seldom (11.1%), but was still low. Conclusion: The prevalence of airflow limitation in this study indicates that a quarter of outpatients with CVD have COPD, almost all of whom are undiagnosed. This suggests that it is important to look routinely for COPD in CVD outpatients. Keywords: COPD, CVD, handheld spirometer, lung function, diagnosis  
Characterization and Test of Intermittent Over RESET in RRAMs
No full textResistive Random Access Memories (RRAMs) are being commercialized with significant investment from several semiconductor companies. In order to provide efficient and high-quality test solutions to push high-volume production, a comprehensive understanding of manufacturing defects is significantly required. This paper identifies and characterizes the over-RESET phenomenon based on silicon measurements. In our case study, 30% cycles suffered from intermittent extremely high resistance state exceeding the high resistance state criteria. The paper shows the limitations of conventional defect modeling based on linear resistors. To address this challenge, the Device-Aware (DA) defect modeling method is applied; a model of the defective RRAM device is developed and calibrated using measurements to accurately describe the impact of the defect on the electrical behavior of the memory device. Afterward, fault analysis is performed based on the DA defect model, and appropriate fault models are introduced; they show that the DA defect model will sensitize deep (extremely high resistance) state faults. Finally, dedicated test solutions for over-RESET devices are proposed.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Computer Engineerin
A case for clarity, consistency, and helpfulness : state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system
No full textCONTEXT: The Endocrine Society, and a growing number of other organizations, have adopted the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to develop clinical practice guidelines and grade the strength of recommendations and the quality of the evidence. Despite the use of GRADE in several of The Endocrine Society's clinical practice guidelines, endocrinologists have not had access to a context-specific discussion of this system and its merits. EVIDENCE ACQUISITION: The authors are involved in the development of the GRADE standard and its application to The Endocrine Society clinical practice guidelines. Examples were extracted from these guidelines to illustrate how this grading system enhances the quality of practice guidelines. EVIDENCE SYNTHESIS: We summarized and described the components of the GRADE system, and discussed the features of GRADE that help bring clarity and consistency to guideline documents, making them more helpful to practicing clinicians and their patients with endocrine disorders. CONCLUSIONS: GRADE describes the quality of the evidence using four levels: very low, low, moderate, and high quality. Recommendations can be either strong ("we recommend") or weak ("we suggest"), and this strength reflects the confidence that guideline panel members have that patients who receive recommended care will be better off. The separation of the quality of the evidence from the strength of the recommendation recognizes the role that values and preferences, as well as clinical and social circumstances, play in formulating practice recommendations
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