207 research outputs found
A comparative study of stress intensity factor extraction techniques for the generalized finite element method
No full textGeneralized Finite Element Method (GFEM) is a Partition of Unity Method where
shape functions are constructed by the product of standard finite element shape
function and some additional shape functions. These additional shape functions
take the benefit of some prior knowledge of the solution. They are especially useful
in fracture mechanics problems where crack singularities are addressed. A
crack can be represented with the help of discontinuous and singular shape functions.
This gives a great flexibility to the user in a choice of an appropriate mesh.
Stress intensity factor is an important quantity in fracture mechanics which is used
to predict the stress state around a crack front. This report presents a comprehensive
study of stress intensity factor extraction techniques: The Contour Integral
Method (CIM), the Cut-off Function Method (CFM) and the Displacement Correlation
Method (DCM). A few techniques are also shown to improve Displacement
Correlation Method with the use of additional sampling points.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2018-05-01The student, Amit Kumar Dhankhar, accepted the attached license on 2016-04-26 at 22:10.The student, Amit Kumar Dhankhar, submitted this Thesis for approval on 2016-04-26 at 22:20.This Thesis was approved for publication on 2016-04-28 at 09:07.DSpace SAF Submission Ingestion Package generated from Vireo submission #9536 on 2016-07-07 at 14:18:07Made available in DSpace on 2016-07-07T21:18:08Z (GMT). No. of bitstreams: 2
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Previous issue date: 2016-04-28Embargo set by: Seth Robbins for item 93323
Lift date: 2018-07-07T21:18:16Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 93323 on 2018-07-08T09:15:29Z
All-norms and all-Lp-norms approximation algorithms
No full textwork was done while the author was at Max-Planck-Institut für Informatik, Saarbrücken, Germany
Negative Social Aspects of Tourism and Sustainable Development: An Empirical Study
No full textThis paper deals with the identification of negative social aspects of tourism that hinders the sustainable tourism development and well being, seriously. The identification is exclusively based on the opinion of sample tourist vis-à -vis the opinion of local people. A methodology has been framed to determine the major, minor and other negative social aspects of tourism. Appling statistical technique on respondents’ opinion, the author identified five major negative social aspects of West Bengal tourism: growth of unscientific massage parlors, exploitation on tourists, over pricing, commercialization of country’s culture/customs and water pollution, which seriously affects the growth of sustainable tourism development. The identified minor negative social aspects are littering, pick pocketing, theft and female prostitution, which also affect tourism. Apart from these, the author identified numerous negative social aspects which affect the industry occasionally, as per capacity. The author suggests that sound ‘Security Systems Management Process’ at operational level should be implemented by the government to arrest the growth of these negative aspects so that they can be nipped in the bud. Other wise the motto of ‘sustainable development and well being’ of studied area will be impeded
Islamic Microfinance: an Interest free Microfinance Model for Poverty Alleviation
No full textThis theoretical paper deals with Islamic microfinance and its rationality in Indian context as a panacea of Muslim poverty. Conventional microfinance system is very effective to alleviate poverty of developing countries. But it could not touch all community of people because of ‘interest’ component in debt and high degree of interest. Muslims dislike that microfinance which is based on ‘interest’ as it is strictly prohibited in Islam. Therefore the motto of financial inclusion is out of reach through conventional microfinance. An alternative interest free microfinance model has been developed in some part of world to include all Muslim poor people within the banking system. India is yet to adopt Islamic microfinance though 20% of total population is Muslim. The author strongly opines that India should adopt Islamic microfinance as a tool for poverty alleviation of Muslims as well as other communities
A parameter back-calculation technique for pavements under moving loads
No full textMaintenance and rehabilitation strategies of pavements are usually made based on the results of performance evaluation. An efficient tool for pavement structural evaluation at network level is the traffic speed deflectometer (TSD) test. In order to deal with TSD measurements, this paper proposes a parameter back-calculation technique. Firstly, the sensitivity of the surface response for an elastic pavement structure with hysteretic damping to different structural parameters is investigated. Then, the ability of the parameter backcalculation technique is verified by conducting a case study. The results show that the proposed technique is able to back-calculate the structural parameters of pavements by analysing TSD measurements. The presented work contributes to the development of parameter back-calculation techniques for the TSD test.Accepted author manuscriptPavement EngineeringDynamics of Structure
Butyrylcholinesterase Inhibitors: Structure-Activity Relationships of 2-Phenylbenzofuran derivatives.
No full textButyrylcholinesterase Inhibitors: Structure-Activity
Relationships of 2-Phenylbenzofuran derivatives
Antonella Fais1*, Giovanna L. Delogu 1, Benedetta Era 1, Amalia Di Petrillo1,
Amit Kumar2,3, Paola Caria4, Sonia Floris1, Francesca Pintus1
1Department of Life and Environmental Sciences, University of Cagliari , Cagliari , Italy;
2Department of Mech., Chem. and Material Engineering , University of Cagliari , Cagliari , Italy;
3Biosciences Sector, CRS4 ,Pula , Italy
4Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
*Corresponding author: [email protected]
Alzheimer’s disease (AD) is an irreversible and progressive brain disorder which is characterized by
progressive memory loss and a wide range of cognitive impairments.1 Although the precise cause of AD is
not completely known, there are some factors that seem to play a significant role in the pathogenesis of AD.
Since AD is characterized by a forebrain cholinergic neuron loss and a progressive decline in acetylcholine, a
possible therapeutic strategy involves the use of cholinesterase (ChE) inhibitors to restore the
neurotransmitter level and thus alleviate AD symptoms.2
Benzofuran scaffold has drawn considerable attention over the last few years due to its profound
physiological and chemotherapeutic properties. Recent studies have also investigated their inhibitory activity
towards ChEs.3,4
In this study, a series of 2-phenylbezonfurans compounds were synthesized and their inhibition
activity towards the ChE enzymes were investigated. We further combined biochemical analysis and
molecular modelling studies to identify selective butyrylcholinesterase (BChE) inhibition by benzofuran
scaffold. In particular, two compounds exhibited the highest BChE inhibition with IC50 values better than the
standard cholinesterase inhibitor compound. Molecular modelling studies highlighted the importance of
catalytic and peripheral site residues in BChE inhibition. Subsequently, the biosafety of the two promising
compounds was evaluated, in NSC-34 cells at the concentration in which BChE activity is inhibited, and no
considerable cytotoxic effect was found.
References
1. Schuster et al. Bioorg. Med. Chem. (2010) 18, 5071.
2. Zemek et al. Expert Opin Drug Saf (2014) 13, 759.
3. Mostofi et al. Eur. J. Med. Chem. (2015) 103, 361.
4. Delogu et al. Bioorg. Med. Chem. (2016) 26, 2308
A Simple New Classification for Diabetic Foot Ulcers
No full textGangrene, infections like abscesses and ulcers are some of the common diabetic foot complications. Of all these, diabetic foot ulcers pose a major public health problem. Around 80% of all the lower limb amputations are preceded by a foot ulcer. There are various classifications for diabetic foot ulcers out of which the two commonly used classifications are Wagners ulcer classification and the classification of University of Texas. The author proposes another simple new classification specific for diabetic foot ulcer which is one of the common diabetic foot complication. This classification is an addition to the authors already existing new classifications on various aspects of diabetic foot so that a new Amit Jains principle and practice of diabetic foot could be devised for improvising and standardizing the practice of diabetic foot. According to this new classification, diabetic foot can be clinically classified into 3 simple classes. [Med-Science 2015; 4(2.000): 2109-20
Contract Farming: Conceptual Framework and Indian Panorama
No full textThis paper deals with conceptual framework of contract farming and portrays Indian scenario especially after announcement of National Agricultural Policy (2000) which encouraged private participation through contract farming. The conception of contract farming is not new in India, but it gets momentum in the era of agricultural globalization, as an alternative method of farming. The study reveals that while contract farming can be effective in introducing new technologies and providing external inputs to farmers, danger lies in firms extending technologies that bring financial benefits in the short-term but result in negative long-term health and environmental impacts. Contract farming is not appropriate for all types of crops. To have a significant poverty impact, crops produced under contract farming should be labour-intensive rather than input-intensive and should be appropriate for production on small plots of land. Since the contracting company is financially stronger than individual farmers, the terms of the contract may go against the farmers. Herein the government will have to come forward
AN APPRAISAL ON CUSTOMER SERVICE OF INDIA POST
No full textThis paper deals with the customer service of a head post office (HPO) under India Post. Data have been collected personally from 100 account holders of the post office. Account holders have been selected at random basis. A questionnaire has been used to collect the primary data. Data has been analyzed through different tables and using statistical tests. In this study, it was found that most of the account holders are satisfied with how the post office provides customer service
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