1,721,119 research outputs found
Exogenous opioids and glycemic homeostasis. Effects of methadone-induced chronic stimulation of opiate receptors
No full textThe relationships between hormones and muscle parameters over the life span in men
No full textThe Gerontologis
Incidental versus clinically diagnosed differentiated thyroid cancer in both adult and elderly subjects: histological characteristics and follow-up in a retrospective analysis from a single institution
No full textPurpose: Most thyroid cancer are incidentally diagnosed. However, little is known on the different modalities of incidental diagnosis in adult versus older patients. Methods: We retrospectively analyzed data from 440 patients consecutively diagnosed with differentiated thyroid cancer (DTC) in a single institution. Modalities of diagnosis were categorized as follows: (A) clinically diagnosed, nonincidental cases; (B) incidental during carotid power-duplex (CPD); (C) incidental during neck imaging other than carotid power-duplex; (D) incidental during imaging workup of thyroid dysfunction or at histological examination after thyroidectomy for benign lesions. Demographics, histology and follow-up were compared between adult (<65 years) and older (≥65 years) patients according to the different modalities of diagnosis. Results: A total of 363 and 67 cases were recorded in adult and older patients, respectively with incidental proportions of 79% and 85%, respectively. A P < 0.001 significant difference in the modality of diagnosis was found between adult and older subjects, the latter presenting with a higher prevalence of Group B. In the nonincidental group, papillary histotype, larger size, and extrathyroidal invasion were more frequently observed in older subjects. Disease-free survival was comparable between adult and older subjects in the incidental cases, whereas it was reduced, though not significantly, in older subjects. Conclusion: Incidental cases of DTC are more frequently diagnosed in the old subjects and are mainly due to CPD. Disease-free survival is comparable between adult and older subjects in both incidental and nonincidental cases, although it may be slightly reduced in nonincidentally diagnosed older patients
Effects of the housing social context on emotional behaviour and physiological correlates in female mice
No full textIn laboratory breeding procedures, mice are usually housed in single-sex unfamiliar groups since weaning, while individual housing is widely employed in many experimental settings. While there is a considerable amount of evidence on the behavioural and physiological effects of various social contexts in male mice
and rats, few data are available on female mice. We examined short-term modulation of social context in the housing environment on exploratory and emotional behaviours in response to novelty (i.e., free-exploratory open field) and on physiology (i.e. organs and body weight, and basal corticosterone level) of female CD1 mice, taking into account the estrous phase as an additional variable. Living alone or grouped with siblings
or with unfamiliar females for a short period (7 days) did not affect any physiological indexes of stress in female house mice and had marginal effects on emotional behaviour. When challenged with a free choice between a novel environment and their home cage, female mice housed with siblings did not differ on any behavioural parameter from females housed with same-aged unfamiliar mice, while individually housed
females showed higher propensity to enter the novel arena but no differences in activity or in anxiety as compared to grouped mice. Information about sex specifics under standard housing conditions as well as in response to common laboratory procedures could be important for the understanding of sex differences in vulnerability to psychiatric disorders and response to drug treatment
Effects of housing social context on emotional behavior and physiological responses in female mice
No full textIn laboratory breeding procedures, mice are usually housed in single-sex unfamiliar groups since weaning, while individual housing is widely employed in many experimental settings. While there is a considerable amount of evidence on the behavioural and physiological effects of various social contexts in male mice and rats, few data are available on female mice. We examined short-term modulation of social context in the housing environment on exploratory and emotional behaviours in response to novelty (i.e., free-exploratory open field) and on physiology (i.e. organs and body weight, and basal corticosterone level) of female CD1 mice, taking into account the estrous phase as an additional variable. Living alone or grouped with siblings or with unfamiliar females for a short period (7 days) did not affect any physiological indexes of stress in female house mice and had marginal effects on emotional behaviour. When challenged with a free choice between a novel environment and their home cage, female mice housed with siblings did not differ on any behavioural parameter from females housed with same-aged unfamiliar mice, while individually housed females showed higher propensity to enter the novel arena but no differences in activity or in anxiety as compared to grouped mice. Information about sex specifics under standard housing conditions as well as in response to common laboratory procedures could be important for the understanding of sex differences in vulnerability to psychiatric disorders and response to drug treatment
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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