3,098 research outputs found
The Classics of the First Lorenzo de' Medici. For a New Critical Reading of Corinth
No full textopenIl presente lavoro si propone di rileggere una delle prime opere di Lorenzo de’ Medici, "Corinto", attraverso temi letterari che lo caratterizzano, tenendo presente i modelli latini, greci e italiani ai quali l’autore attinge e confrontandone altri, pertinenti ai temi analizzati. Dopo una rapida introduzione sul contesto storico in cui il poemetto si inserisce, esso viene presentato per quanto concerne il contenuto e la storia redazionale, approfondita nell’Appendice, dove si presentano inoltre i testi di riferimento. Segue dunque la nuova lettura critica. La riflessione sul concetto di classico e su Lorenzo quale autore e personaggio del poemetto conclude l’analisi.The present work aims to re-read one of Lorenzo de’ Medici’s first works, "Corinto", through the literary themes which characterize it, keeping in mind the Latin, Greek and Italian models on which the author draws and comparing others, pertinent to the themes analyzed. After a quick introduction to the historical context in which the poem fits, it is presented in terms of content and editorial history, detailed in the Appendix, where the reference texts are also presented. Thus follows the new critical reading. The reflection on the concept of classic and on Lorenzo as author and character of the poem concludes the analysis
Generazione di modelli H-BIM tramite intelligenza artificiale
No full textI dati del nostro patrimonio culturale ottenuti mediante
rilievi tridimensionali rappresentano strutture geometriche
complesse non strutturate. L’introduzione di metodi automatici
di segmentazione semantica e gerarchia tra le parti,
permetterebbero la comprensione e l’utilizzo di questi dati
nelle operazioni di salvaguardia del bene. In questo contesto,
il contributo presenta un workflow semi automatico per la
ricostruzione tridimensionale di modelli H-BIM, sfruttando
un approccio di classificazione gerarchico (MLMR) per l’ottimizzazione
dei risultati
Extracellular Vesicles-mediated communication among brain cells
Full text linkThis thesis results from the research activity conducted during my Ph.D. in Biochemistry and Molecular Biology (BiBiM 2.0) starting in 2019. The Pegaso initiative of the Tuscan Region sponsored the BiBIM 2.0 Ph.D. program, and I conducted most of my work in the Biochemistry lab of Claudia Martini, Full Professor of Biochemistry, at the Department of Pharmacy of the University of Pisa, Italy. In 2021, I spent six months in the lab of Marcal Vilar at the Molecular Basis of Neurodegeneration Unit lab, located in the Institute of Biomedicine of València, Spain.
The main topic of my Ph.D. thesis is the role of extracellular vesicles (EVs) as mediators of intercellular communication in the brain. This choice was motivated by a naïve interest in the basic biochemistry underlying these subcellular structures. Furthermore, EVs represent an excellent opportunity to build fully biological protein- or nucleic acid- based drugs in the future. This premise prompted our research group to investigate two aspects of EV function. On the one hand, I set-up and validated one protocol for extracting EVs from two human microglial cell lines. I performed a biophysical characterization on these EVs and investigated their biological effect both on microglia itself and on a line of glioblastoma cells. We started analyzing the effect on EVs from untreated microglia, and we carried on by analyzing EVs from inflamed microglia. Next, I investigated one possible role of neurotrophins as a molecular system by which EVs could gain specificity of action. This was motivated by my previous studies on neurotrophins and their receptors, performed during my master’s degree, and by the possibility of joining the lab of Marcel Vilar, an internationally recognized expert on neurotrophins. The results of these studies have been organized into three chapters, and one appendix.
In Chapter 1, I will introduce EVs, presenting a brief historical context and how they are classified. I will focus on their function in cell-to-cell communication and their implication in neuroinflammation, which will be a significant part of this thesis. I will also talk about the present knowledge of their production and secretion from the parental cells and their uptake by the recipient cells.
In Chapter 2, I am going to give an introduction concerning microglia and the role of microglia-derived EVs in the communication among brain cells. After that, I will present my experimental work in characterizing the biophysical properties of EVs extracted from two microglia cell lines (C20 and HMC3), investigating their biological effect and ability to propagate inflammation to neighboring cells.
Chapter 3 will focus on a possible mechanism to increase EVs’ targeted delivery. The first part will introduce the neurotrophin system, and the second part will integrate all the experimental work I performed on the neurotrophins and their receptors, with a particular focus on the investigation of the NGF-mediated p75-TrkA interaction as a molecular mediator of EVs uptake by recipient cells.
In Chapter 4, I will draw the main conclusions from my experimental work and delineate how this could be prosecuted in the following years.
Finally, appendix I will describe the work I’ve done during my period abroad in the Institute of Biomedicine of Valencia. This work didn’t involve extracellular vesicles but was dedicated to a better understanding of the neurotrophin system
IL CINEMA A PASSO RIDOTTO DI COSTANTINO CECCARELLI
No full textLa tesi è un primo passo su una ricerca che riguarda la figura di Costantino Ceccarelli, cineasta del passo ridotto di Viareggio. A partire dalla storia della FEDIC, concentrandosi in particolare sugli anni '60, si cerca di ripercorrere la vita e la filmografia del regista, per poi analizzare i suoi due film principali, considerati autentici capolavori del cineamatorismo. Infine, viene fatto un paragone con un regista del mondo professionale e autoriale, lo svedese Ingmar Bergman, il cui stile fu preso a modello da Ceccarelli. In conclusione, una proposta per la realizzazione di un documentario
The defensive system of Montecatini Val di Cecina. Digital integrated relief for knowledge and enhancement
No full textOn the occasion of the Fortmed 2024 held in Tirana was presented, by the same authors, a first contribution on the ancient village of Montecatini Val di Cecina, still dominated by the imposing tower of the Belforti (from now on Tower) one of the most powerful families of the Volterra’s territory in sec. XIII. Important are the transformations that have affected the territory surrounding the village, first with the plant of a copper mine now transformed into a museum and more recently, with the exploitation of wind energy. The intent of the article already presented was to document, albeit through the initial acquisitions arising from archival, bibliographical and iconographic surveys, the results of the initial phase of research whose main objectives are knowledge and diachronic interpretation of the current urban conditions. The identification and diachronic interpretation of the residual traces of the ancient defensive system is testified, in addition to the Tower, also by the presence of circular towers, coeval or after the construction of the same Tower (1340). This paper documents, as indicated in the final part of the article Fortmed 2024, the expected developments of the research undertaken and which also include a more careful and thorough analysis of the Tower. The further steps of the research move in the first place from the indispensable acquisitions resulting from the integrated instrumental survey operations, performed with 3D laser scanning and drone photogrammetry. Beyond the operational issues related to major operations, the contribution aims to explain how the 3D restitution of the village of Montecatini Val di Cecina, although useful for the main objectives assumed on the basis of the research, is not only a necessary tool to undertake operations of protection and enhancement but also to activate innovative modes of communication all aimed at extending the dissemination of historical knowledge of the village, to be understood as a necessary and desirable cultural and tourist resource, to the wider catchment area
Industrial landscape Evolution in the Devil's Valley
No full textThe evolution of the specific characteristics of
the landscape in the context under investigation,
is as in other areas, strongly influenced
by industrial development. In the Devil’s Valley,
located in the upper Val di Cecina, with
the activation of the borax industry first, and
later with the transformation of geothermal resources
into electricity and district heating, the
original landscape, consolidated and resulting
from human transformations related mainly to
agro-forestry pastoral activities has undergone
a sudden upheaval. The natural presence of the
‘Lagoni’ and the ‘soffioni’ has been overlapped,
with greater intensity since the early ‘800, a
new economy in the landscape, through the
stratification of the complex of establishments,
machinery and equipment in relation to the development
of different industrial activities. In
recent decades, with the establishment of the
imposing Enel power plant, the cooling towers,
the characteristic system of the imposing
steam pipes that wind in the most varied planimetric
and altimetric conformations marks in
a very particular way the compositional matrices
of the territory. The present contribution
aims to document the first results of a wider
research on the evolution of the landscape in
the Devil’s Valley
La torre Belforti e il Sistema difensivo di Montecatini Val di Cecina.
No full textThe small village of Montecatini Val di Cecina, capital of one of the largest municipalities in the province of Pisa is perched at an altitude of approx. 420m above sea level and located on one of the last southern offshoots of the Pisan hills. The Montecatini’s first attestation, subject to the civil jurisdiction of the bishop of Volterra, important city of Etruscan origin, dates back to the end of sec. XI. Montecatini is mentioned as a castle only in May 1225, under the bishopric of Pagano Pannocchieschi. The Belforti family, with the taking of power in Volterra in 1340 and especially following the Filippo’s appointment on the episcopal chair, affirms itself in Montecatini entrusting the construction of the imposing tower to the stone master Ghetto da Buriano, in 1354, on the remains of an earlier structure. To the same, we owe the strengthening of the defensive wall system of the castle and, in the following year, the construction of a residential building. The tower of 30m approx. and the keep, of the latter remain today only a few traces, represent the essential component of the defensive system of the castle, of which today are still visible the towers with circular section. Towards the middle of the 14th century the domain of Montecatini was taken away from the Belforti family and handed over by the Florentines to the town of Volterra until, in 1472, it was subjected to the Florentine republic together with its countryside. At the end of the 60’s the tower was bought by Emilio Jesi, entrepreneur and important art collector (whose collection was donated to the Pinacoteca di Brera in Milan), who made the restoration project of the illustrious architect Franco Albini. The main objective of the work presented is to return, also graphically, new reconstructive hypotheses of the fortified system of Montecatini Val di Cecina, on the basis of the acquisitions resulting from the profitable overlap between the archival documentation and the results of the survey
The Capuchin convent and the church of san Matteo al Posatoio in Volterra. History, Survey and reuse.
No full textIl bastione di Sant'Agnolo a Volterra. Riqualificazione della struttura fortificata e rigenerazione urbana
No full textLa Catedral de San Lorenzo, corazón de la devoción de los Genoveses y de la ritualidad republicana, siglos XVI-XVII
No full textLa catedral de Génova, consagrada en 1118 y terminada varios siglos después, está dedicada a San Lorenzo. Desde el siglo XIV, este majestuoso edificio se convirtió en el corazón de la devoción de los Genoveses y conquistó una centralidad absoluta en la historia de la Comuna y luego en la de la Repú-blica. Los protagonistas de la época de las cruzadas le donaron tesoros y reliquias que se convertirían en las más importantes de Génova. En 1637, San Lorenzo fue escenario de una ceremonia de gran valor político: la concesión a la Virgen de la soberanía nominal sobre la ciudad. En 1656, durante la más terrible peste del antiguo régimen genovés, se llevaron al campanario de la catedral las cenizas de San Juan, el Precursor, y se alzaron al cielo para bendecir todas las casas, plazas y calles. Todos los Geno-veses se arrodillaron en la oscuridad y rezaron para obtener la intercesión divina. Todos dirigieron su mirada hacia la misma luz: su catedra
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