806 research outputs found
Depression and Gender: The Expression and Experience of Melancholy in the Eighteenth Century
No full textThis thesis investigates the life and work of six eighteenth-century writers, two male and four female. It explores their experience of depression through their letters and other autobiographical material, and examines the ways in which they represent melancholy in their poetry and prose. The subject of Chapter Two is Thomas Gray, whose real life persona as the lonely intellectual is also identifiable in his poetry. The Scottish poet Robert Fergusson is studied in Chapter Three. Fergusson’s lively and vigorous mind was shattered in the months leading up to his death, during which time some of his writing became darkly nihilistic. Chapter Four looks at Anne Finch, Countess of Winchilsea, a lifelong depressive who often wrote about her feelings of despair in her poetry. Chapter Five explores Lady Mary Wortley Montagu. She was a courageous and controversial figure, but despite her resilience, on occasion in her letters she reveals her vulnerability and susceptibility to low spirits, a mood which is sometimes expressed in her creative writing. Sarah Scott, whose life and work have not yet been considered in relation to the subject of melancholy, is examined in Chapter Six. Her novel includes several low-spirited and depressed female characters who are continually seeking asylum from a hostile world. Chapter Seven analyses Charlotte Smith, a mother of twelve children whose unhappy marriage ended in separation. Smith wrote extensively about her depression in her letters, prefaces, poetry and novels.
This study shows that the women in particular use their writing on melancholy and depression to express their discontent with the confined way in which they are often expected to live out their lives
DC050
No full textThe poem and drawing were created for William Henry Harrison's campaign for President of the United States.On the reverse side is written the caption "Designs for Harrison Caricatures given me by Gov. Corwin." Author and artist unknown
Growth differentiation factor 9: bone morphogenetic protein 15 synergism and the potential involvement of heterodimerization
No full textLetterDavid G. Mottershead, Craig A. Harrison, Thomas D. Mueller, Peter G. Stanton, Robert B. Gilchrist and Kenneth P. McNatt
From Material to Symbol, to Model:The Bridge
No full textThis lecture will present the bridge as a structure of interconnectivity by which one passes from one form or familiarity to another. The bridge is a model of communication. By locking two into the space of one, it enables thought and the experience of the social. Interdisciplinarity and transculturality also depend on bridges, approachable with lesser or greater degrees of enthusiasm. Ethics itself depends on a bridge, endorsing, like bridges at their best, reciprocal relationship. Harrison’s presentation will articulate several features of bridge-form while examining case studies that range from material history (bridges of trade and war, for example) to the ambitions of religion (binding a here to a transcendent there) and to accomplishments of poetry, music, and philosophy. Some specific exegeses will even aim to exemplify the otherwise theorized bridges between disciplines and the cultures articulated within them. For bridges are built not merely by putting things in contact, but by creating traffic between them. Thomas Harrison is Professor of European Languages & Transcultural Studies at the University of California at Los Angeles. It is from his most recent study — Of Bridges: A Poetic and Philosophical Account (2021) — that this presentation is culled. He is also the author of 1910: The Emancipation of Dissonance, a study of pan-European expressionism, and of Essayism: Conrad, Musil and Pirandello. His L’arte dell’incompiuto has appeared in Italian. He has edited Nietzsche in Italy, with contributions by Agamben, Serres, and Nancy; The Favorite Malice: Ontology and Reference in Contemporary Italian Poetry; and, with Gian Maria Annovi, The Ends of Poetry, containing critical studies alongside an anthology of forty contemporary poets. He has written essays on Georg Simmel, Claudio Magris, Carlo Michelstaeder, Gianni Vattimo, Michelangelo Antonioni, and several topics in the comparative arts
Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer
No full textThis work was supported by the Chief Scientist Office, Scotland (ETM37; to G.D. Stewart, A.C.P. Riddick, M. Aitchison, and D.J. Harrison), Cancer Research UK (Experimental Cancer Medicine Centre; to T. Powles, London and D.J. Harrison, Edinburgh), Medical Research Council (to A. Laird and D.J. Harrison), Royal College of Surgeons of Edinburgh (to A. Laird), Melville Trust (to A. Laird), Medical Research Council (MC_UU_12018/25; to I.M. Overton), Royal Society of Edinburgh Scottish Government Fellowship cofunded by Marie Curie Actions (to I.M. Overton), Renal Cancer Research Fund (to G.D. Stewart), Kidney Cancer Scotland (to G.D. Stewart) and an educational grant from Pfizer (to T. Powles).Purpose: The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental design: Multiple tumor samples (n=187 samples) were taken from the primary renal tumors of mccRCC patients who were sunitinib treated (n=23, SuMR clinical trial) or untreated (n=23, SCOTRRCC study). ITH of pathological grade, DNA (aCGH), mRNA (Illumina Beadarray) and candidate proteins (reverse phase protein array) were evaluated using unsupervised and supervised analyses (driver mutations, hypoxia and stromal related genes). ITH was analysed using intratumoral protein variance distributions and distribution of individual patient aCGH and gene expression clustering. Results: Tumor grade heterogeneity was greater in treated compared to untreated tumors (P=0.002). In unsupervised analysis, sunitinib therapy was not associated with increased ITH in DNA or mRNA. However, there was an increase in ITH for the driver mutation gene signature (DNA and mRNA) as well as increasing variability of protein expression with treatment (p<0.05). Despite this variability, significant chromosomal and transcript changes to key targets of sunitinib, such as VHL, PBRM1 and CAIX, occurred in the treated samples. Conclusions: These findings suggest that sunitinib treatment has significant effects on the expression and ITH of key tumor and treatment specific genes/proteins in mccRCC. The results, based on primary tumor analysis, do not support the hypothesis that resistant clones are selected and predominate following targeted therapy.Peer reviewe
Thomas Tryon, (biographical Index no.101027783); William Banting, (Index no. 101001320); Jonathan Green, (Index no. 101011392); Howard Williams,(Index no. 101041000); Josiah Oldfield, (Index no. 101040999); Ernest Bell, (Index no. 101040996)
No full textThese new DNB entries trace the lives of various auto-didact nutritionists and hygiene enthusiasts. Thomas Tryon was the leader of a fashionable vegetarian circle in London and a popular author on health at the end of the seventeenth century; Jonathan Green was the proprietor of a famous set of medicinal 'fumigating' or vapour baths in London between c 1820-50; William Banting promoted a highly successful, European-wide, high-protein slimming diet in the 1860s; Josiah Oldfield was a popular medical author and supporter of vegetarianism, the Fruitarians, humanitarianism, and founded the Society for the Abolition of Capital Punishment in 1901; Howard Williams was a historian of vegetarianism, an anti-vivisectionist, and helped found the Humanitarian League in 1890; Ernest Bell was a publisher with links to the Vegetarian Society, the Humanitarian League, and numerous late-nineteenth century animal welfare groups
Characteristics of Saharan dust emission mechanisms in boreal summer: a satellite and modelling approach
No full textMineral dust is one of the most abundant atmospheric aerosols and has a wide range of impacts on climate, meteorology, health and biogeochemistry. North African sources are responsible for about half of the total atmospheric burden, peaking as an emission source in the boreal summer months of June, July and August. In-situ data from the Fennec observation campaign of 2011 and 2012 indicates that cold pool outflows (CPOs) from convective downdrafts are the primary meteorological driver of these summertime emissions, followed by nocturnal low-level jet (LLJ) breakdown, both mesoscale phenomena which numerical models struggle to represent faithfully. Very few surface observations are available to characterise these emission mechanisms, however, and the extent to which Fennec observations are representative remains unclear. Satellite data from the Spinning Enhanced Visible and Infrared Imager (SEVIRI) offers both the volume of data and resolution to observe emission mechanisms on the long term.
In this thesis, two sets of automated algorithms are applied to 14 years of summertime SEVIRI data, the first of which categorises automatically identified and tracked dust by emission mechanism and the second of which tracks and characterises dust-laden cold pool outflows. CPOs account for 82% of the total observed dust and 88% at the point of emission in the central and western Sahara during boreal summer, which is the highest estimate yet of their contribution. Whereas CPO dust is widespread and the majority of dust source regions are primarily CPO-driven, LLJs dominate a small number of hotspots such as the Tidihelt Depression. CPOs are far-reaching, with 22.5% travelling over 300 km. They also follow a clear diurnal cycle which favours emissions in the late afternoon and evening. Unlike dust emission, CPO frequency peaks in August in southern Algeria.
In the final component of the thesis, satellite observations are used to support a Met Office Unified Model experiment diagnosing the role of orography in driving dust-emitting LLJs over central Algeria. Fluvial drainage from mountains is thought to contribute erodible sediment to western Saharan dust sources, but their effect upon emission mechanisms there is untested. Removing the Hoggar mountains reduces LLJ emission frequency by approximately 30% as an elevated heating anomaly helps sustain the strong pressure gradient driving low-level winds across the region in summer.
This thesis offers a meteorological perspective on satellite dust source maps, showing the contribution of erosivity to known summertime emission hotspots on climatic timescales. The fact that most central and western Saharan dust sources are predominantly activated by CPOs poses a challenge for numerical modelling of the dust cycle given the inadequate representation of downdrafts in models with convective parameterization
The Favourite Book of Fables
No full textThis book reproduces the 1890 original version by Thomas Nelson and Sons. Pryor Publications is, in their own terms, Specialist in Facsimile Reproductions. I also have a copy of the 1891 printing. This version continues the early edition's beautiful pictorial spine and covers, featuring good colored illustrations of five fables. Noteworthy inside is the mix of illustrators and illustration styles. I think I can detect four different styles and, presumably, sources. (1) The sharpest and best here is a set of mid-sized rectangular engravings by W. Small (e.g., 17 and 25). (2) The largest occupy a full page, broken in some way by the presence of text (e.g., 13 and 57). (3) Next in size comes a set of large squares (59 and 75). Either of these last two categories may be by or from Weir. The TB illustration on 73 seems to be Weir's illustration given by Hobbs on 105 with text inserted, but I find a different TB illustration in my own Weir editions! (4) The smallest rectangles seem to be a poor man's Bewick (11 and 20). I wish I could place the source of the ass's sprawl on 49 and the cover.This is a hardbound book (hard cover
A 14 year climatology of Saharan dust emission mechanisms inferred from automatically tracked plumes
No full text The central and western Sahara (CWS) is the largest source of mineral aerosols during boreal summer, but observed ground‐based data are extremely scarce and typically distant from key source regions. Knowledge of dust emission mechanisms has therefore been mostly limited to short‐term observations from a point or model approximations. To address this deficiency, dust plumes from the CWS are classified according to emission mechanism for June, July and August of 2004‐2017 using an automated inference method which accurately tracks the timing, convective association and geometry of plumes observed with the Spinning Enhanced Visible and Infrared Imager (SEVIRI) aboard Meteosat Second Generation satellites. From these characteristics, plumes are classified as either low‐level jet or cold pool outflow events. The extensive data set is used to generate the largest available climatology of dust emission sources and Saharan emission mechanisms. Automated inference compares well with ground‐based measurements from the Fennec Campaign (76% accuracy) as well as with an entirely manual approach (88% accuracy). Cold pool activity accounts for 82% of total observed dust and 88% at the point of emission. Dust from cold pools evolves seasonally from hotspots around the Mali‐Niger‐Algeria border triple point towards the central Sahara to the northwest, while dust from low‐level jets is organised along the axis of the northeasterly Harmattan, and dominates emission within the Tidihelt Depression of central Algeria. The widespread importance of cold pool outflows in this research supports the findings of the Fennec Campaign, but low‐level jets remain highly significant in certain isolated hotspots. </p
The works of Mary Birkett Card 1774-1817 originally collected by her son Nathaniel Card in 1834: an edited transcription with an introduction to her life and works in two volumes
No full textThis thesis makes available the writings of Mary Birkett Card, a Dublin Quaker,
as collected by her son Nathaniel Card in 1834. It provides an annotated
transcription of the manuscript collection, with textual and editorial notes, and
an introduction recovering her life within her cultural community. The writings
consist of a spiritual autobiography, 43 religious letters, other prose pieces and
over 220 poems. Two poems were published in her lifetime: A Poem on the
African Slave Trade (1792) and Lines to the Memory of our Late Esteemed and
Justly Valued Friend Joseph Williams (1807).
The introduction is in three parts. Part 1 offers a biographical outline and sets
Mary Birkett Card's childhood poems in the context of the Quaker community in
which she grew up. Part 2 explores her autobiography, questioning concepts
of a separate female autobiographical tradition. It then investigates her
encounter with 'deist' thought, and later conflicts, after her marriage. These
concern money (seeking to reconcile the spiritual and material) and issues of
language and gender (a desire for'a pure language', linked to constraints upon
women's speech). Part 3 contrasts her 1790s verse with her later poems, and
epistles, arguing that embedded within these works as a whole lies a struggle
with her literary imagination.
Throughout, the writings are set within the context of contemporary literary
forms in poetry, Quaker writing and women's writing. They are considered in
relation to now current critical debates - on public and private spheres,
autobiography, abolitionist verse, women's intimate friendships, domesticity,
philanthropy and sensibility. It is shown that Mary Birkett Card's literary
creativity was intimately connected with her Quakerism, and, moreover, with
attempts to negotiate an ideal of Quaker womanhood. One important aspect is
the challenge her work poses to assumptions, still generally prevalent, about
Quaker women's far greater autonomy within marriage in comparison to
women in society at large
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