186 research outputs found
Oral history interview with Sly Alley
No full textSly Alley, author and poet, recalls his youth growing up in Tecumseh, Oklahoma, and some of his early experiences as a Native American. He discusses his educational journey, his various jobs, and how he became interested in writing poetry. He also talks about his creative process and about sources of inspiration. Alley received the 2017 Oklahoma Book Award for poetry.The Deep Roots: Oklahoma Authors Collection is a series of interviews with authors who discuss their lives, work, and creative processes
A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse.
No full textIntragenomic conflicts arise when a genetic element favours its own transmission to the detriment of others. Conflicts over sex chromosome transmission are expected to have influenced genome structure, gene regulation, and speciation. In the mouse, the existence of an intragenomic conflict between X- and Y-linked multicopy genes has long been suggested but never demonstrated. The Y-encoded multicopy gene Sly has been shown to have a predominant role in the epigenetic repression of post meiotic sex chromatin (PMSC) and, as such, represses X and Y genes, among which are its X-linked homologs Slx and Slxl1. Here, we produced mice that are deficient for both Sly and Slx/Slxl1 and observed that Slx/Slxl1 has an opposite role to that of Sly, in that it stimulates XY gene expression in spermatids. Slx/Slxl1 deficiency rescues the sperm differentiation defects and near sterility caused by Sly deficiency and vice versa. Slx/Slxl1 deficiency also causes a sex ratio distortion towards the production of male offspring that is corrected by Sly deficiency. All in all, our data show that Slx/Slxl1 and Sly have antagonistic effects during sperm differentiation and are involved in a postmeiotic intragenomic conflict that causes segregation distortion and male sterility. This is undoubtedly what drove the massive gene amplification on the mouse X and Y chromosomes. It may also be at the basis of cases of F1 male hybrid sterility where the balance between Slx/Slxl1 and Sly copy number, and therefore expression, is disrupted. To the best of our knowledge, our work is the first demonstration of a competition occurring between X and Y related genes in mammals. It also provides a biological basis for the concept that intragenomic conflict is an important evolutionary force which impacts on gene expression, genome structure, and speciation
Data analyzed in the Palgrave Communications article, “The Argentine Portion of the Soybean Commodity Chain”
No full textData analyzed in the Palgrave Communications article, “The Argentine Portion of the Soybean Commodity Chain”.The datasets analysed during the current study. All data were originally obtained from publicly accessible websites. These datasets were derived from the following public domain resources: Argentine National Statistic Institute INDEC. http://www.indec.gov.ar National Agricultural CENSUS. http://www.indec.gov.ar/nivel4_default.asp?id_tema_1=3&id_tema_2=8&id_tema_3=87 USDA United States Department of Agriculture Foreign Agricultural Service https://apps.fas.usda.gov/psdonline/app/index.html#/app/advQuery Argentine Ministry of Finance http://www.economia.gob.ar TELAM, Argentine National Press Agency, 2014. http://www.telam.com.ar Worldbank http://databank.worldbank.org/ddp/home.do?Step=2&id=4 Publication Date: 07/05/2017 Author: Maria Jose Haro Sly Contact: Federal University of Santa Catarina – [email protected]
Lawyer Sly
No full textA man tries different professions.https://egrove.olemiss.edu/kgbsides_uk/1860/thumbnail.jp
Wright 14
No full textAnother nicely conceived work by Biro. Sixteen pages. I have been fortunate to find the whole set of #13-18 on eBay. Biro's style remains engaging. Clouds of steam arising from the delicious food are important in this version. So is the repetition of the phrase What a sly fox! in What a clever stork! This version of the story is developed differently from Biro's presentation in The Fox and the Stork and The Man, His Son and the Ass from Award Publications in 2001. Perhaps the best illustration in this version has the fox laughing while the stork looks down chagrined at her full, steaming bowl of soup.Oswald Watzk
Depletion and reconstitution of macrophages in mice
No full textMacrophages are critical players in the innate immune response to infectious challenge or injury, initiating the innate immune response and directing the acquired immune response. Macrophage dysfunction can lead to an inability to mount an appropriate immune response and as such, has been implicated in many disease processes, including inflammatory bowel diseases. Macrophages display polarized phenotypes that are broadly divided into two categories. Classically activated macrophages, activated by stimulation with IFNγ or LPS, play an essential role in response to bacterial challenge whereas alternatively activated macrophages, activated by IL-4 or IL-13, participate in debris scavenging and tissue remodeling and have been implicated in the resolution phase of inflammation. During an inflammatory response in vivo, macrophages are found amid a complex mixture of infiltrating immune cells and may participate by exacerbating or resolving inflammation. To define the role of macrophages in situ in a whole animal model, it is necessary to examine the effect of depleting macrophages from the complex environment. To ask questions about the role of macrophage phenotype in situ, phenotypically defined polarized macrophages can be derived ex vivo, from bone marrow aspirates and added back to mice, with or without prior depletion of macrophages. In the protocol presented here clodronate-containing liposomes, versus PBS injected controls, were used to deplete colonic macrophages during dextran sodium sulfate (DSS)-induced colitis in mice. In addition, polarized macrophages were derived ex vivo and transferred to mice by intravenous injection. A caveat to this approach is that clodronate-containing liposomes deplete all professional phagocytes, including both dendritic cells and macrophages so to ensure the effect observed by depletion is macrophage-specific, reconstitution of phenotype by adoptive transfer of macrophages is necessary. Systemic macrophage depletion in mice can also be achieved by backcrossing mice onto a CD11b-DTR background, which is an excellent complementary approach. The advantage of clodronate-containing liposome-mediated depletion is that it does not require the time and expense involved in backcrossing mice and it can be used in mice regardless of the background of the mice (C57BL/6, BALB/c, or mixed background).Peer reviewedfinal article publishe
“Satisfied Life Years” in the former Yugoslav countries
No full textThis paper proposes a subjective indicator of quality of life. The author defines this indicator as Satisfied Life Years (SLY) based on the fact that being alive is an essential prerequisite for enjoying any quality of life. While life expectancy is at the basis of this indicator, SLY also reflects that mere survival is not enough; therefore, life years are combined with the subjective assessment of satisfaction with different domains of life. Based on data from the EU-SILC survey and WHO life tables, the author uses the well-established Sullivan method. SLY are calculated by weighting in a life table the age-specific person-years lived with age-specific proportions of satisfaction with different domains of life (health, financial situation, personal relationships, living environment, and happiness). The subjective character of SLY makes it adequate for assessing and comparing the quality of life in homogeneous nations/countries/regions. Therefore, the focus of the paper is on the former Yugoslavia given the similarities in terms of mentality and cultural characteristics in the republics. The main results indicate the following: (1) there is a large gap of as much as 25 years (on average for former Yugoslav republics) between total years of life and actually satisfied years; (2) the economic and ecological dimensions are the dimensions with the most dissatisfaction of quality of life in the former Yugoslav republics; (3) happiness is associated with a good relationship with family, friends, and colleagues as well as good health in all former Yugoslav republics, which reflects the traditional background in the former Yugoslav region
The Alphabet Series
No full textThis disc has two fables, besides its songs and stories, with a steady background of classical music. They are Tracks 23 and 24. Both feature a narrator with a non-native English accent. The Farmer And His Sons (and the bundle of sticks) runs 1:47 and climaxes in the lesson Working together to get something usually works out best. FG runs 2:27 and emphasizes almost everything in the story. Thus this is a sly old fox, he is very hungry, and he jumps many times. Sometimes when we cannot get what we want, we pretend that we didn't really want it at all.Series compiled by Lucy Toppetta. Music by Matthew Campanozzi. Narration and Singing by Emilu Production
On Sunday 1955, I'll never forget the date (day?)
No full textSatirical, sly, humourous and insulting song about Mr. and Mrs. Mackey, who came to Bellburns as teachers (perhaps with a "merchant" overtone). Mentions many local people by name. Author mentions fear of being arrested by RCMP because of blatant insults used.Authorship attributed to informants, Mrs. Clara "Aunt Clad" Stevens. This seems to be a version of "Wabash Cannonball"
The Captain with his Whiskers took a Sly Glance at Me
No full textA woman is courted by a captain.https://egrove.olemiss.edu/kgbsides_uk/2336/thumbnail.jp
- …
