1,721,157 research outputs found
[Pharmacological prevention of coronary relapses in Italian clinical practice: a literature review]. La prevenzione farmacologica delle recidive coronariche nella pratica clinica Italiana: Una revisione della letteratura
No full textScientific advances in cardiovascular research during the last decades have afforded effective pharmacological treatment to those surviving their first acute myocardial infarction. This secondary prevention treatment, based upon the combined administration of statins, aspirin, beta-blockers and renin-angiotensin blockers, might avert great part of the relapses contributing substantially to the overall incidence of acute coronary syndromes in the general population. However, a treatment gap separates evidence-based recommendations from their daily clinical application, a condition frequently explored even in the Italian medical setting. However, a general overview of the problem is missing insofar, a contribution that might eventually help to improve the status of secondary coronary prevention in our national environmen
Novel statins: pharmacological and clinical results.
No full textRosuvastatin (ZD4522) and pitavastatin (NK-104) are novel HMG-CoA reductase inhibitors with a peculiar pharmacological profile. In particular, they show a high potency in decreasing LDL-C and their catabolism is not mediated by the cytochrome P-450 3A4, thus reducing the potential for drug-drug interaction and improving the management of blood cholesterol. As the magnitude of LDL-C reduction is directly associated with the decrease in the incidence of myocardial infarction and mortality for CAD, statins with increased LDL-C lowering potency may ensure the achievement of target LDL-C levels and offer a more aggressive cholesterol control, further improving CAD morbidity and mortality
Nuove linee guida americane 2013 ACC/AHA sul trattamento del colesterolo plasmatico per ridurre il rischio cardiovascolare aterosclerotico: confronto con le raccomandazioni ESC/EAS per la gestione delle dislipidemie
Full text linkNo abstract availabl
Lifestyle interventions and nutraceuticals: Guideline-based approach to cardiovascular disease prevention
No full textLowering low-density lipoprotein cholesterol (LDL-C) levels is associated with a well-documented reduction in
cardiovascular (CV) disease (CVD) risk. Current guidelines and literature support lifestyle interventions as the
primary strategy for reducing CV risk. Association of dietary modifications (such as the Mediterranean diet),
physical activity and the cessation of smoking with reduced CV morbidity and mortality has been evidenced.
Where lifestyle interventions are not adequate for lowering LDL-C levels and CV risk, pharmacological therapies,
most commonly statins, may also be considered. The benefits of lifestyle and pharmacological interventions in
the prevention of CVD are widely known, but poor adherence and persistence to these necessitate an approach
that aims to improve LDL-C lowering for CVD prevention.
Nutraceuticals (targeted functional foods or dietary supplements of plant or microbial origin) are included in
EU guidelines as lifestyle interventions and may provide an additional approach to controlling LDL-C levels
when a pharmaceutical intervention is not (yet) indicated. However, among different nutraceuticals, the level of
clinical evidence supportive of efficacy for lipid lowering needs to be considered. Meta-analyses of randomised
clinical trials have demonstrated that some nutraceuticals (e.g. red yeast rice and berberine) and some nutraceutical
combinations improve lipid profiles, including lowering of LDL-C, total cholesterol and triglyceride
levels. Therefore, nutraceuticals may be considered in specific patient groups where there is appropriate evidence
to support the efficacy and safety
Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis
Full text linkPMCID: PMC3539993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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