7,392 research outputs found
Sequence alignment of RecA family proteins from ( RadA), (RadA), (Rad51), (Rad51 and Dmc1), (Dmc1 and ScRad51) and (RecA)
No full text<p><b>Copyright information:</b></p><p>Taken from "Crystal structure of the left-handed archaeal RadA helical filament: identification of a functional motif for controlling quaternary structures and enzymatic functions of RecA family proteins"</p><p></p><p>Nucleic Acids Research 2007;35(6):1787-1801.</p><p>Published online 28 Feb 2007</p><p>PMCID:PMC1874592.</p><p>© 2007 The Author(s)</p> All these RecA-like strand exchange proteins have similar N-terminal domains. The C-terminal RecA domains have been removed for clarity. Secondary structural features of the left-handed RadA helical filament are indicated in cyan (α helices) and red (β strands). Functional motifs are indicated under their corresponding amino acid sequences: the putative dsDNA binding HhH motif, the putative ssDNA binding L1 and L2 loops, the ATP binding Walker A and B motifs, the polymerization motif (PM), the subunit rotation motif (SRM), and others. Positions of the R–E–E triad are indicated using blue arrows
The Reporter, February 1988
No full textThe Reporter is a publication produced by Western Carolina University featuring news, events, and campus community updates for faculty and staff. The publication began in August of 1970 and continues digitally today. Click on the link in the “Related Materials” field to access recent issues.REPORTER A Weekly Newsletter
for the Faculty and Staff
of Western Carolina University
Cullowhee, North Carolina February 5,1988
Promotirig teaching, excellence
Task force announces spring activities
In the last semester of its three-year
charge from Chancellor Myron L.
Coulter, the Task Force on Teaching
Effectiveness and Faculty Development
is still going strong and working on new
projects—doing some research, developing
a "field guide," and planning
special events.
The latest thrust of activity involves
distilling some basics on teaching and
learning from the scholarship into a
form convenient for every faculty
member at Western to use.
In December, the Task Force presented
to the Chancellor its "document,"
representing months of research
and work. The document summarizes
the findings of research on teaching
and learning, draws conclusions with
regard to Western, and makes recommendations
for further action by the
university. One concern is sustaining
the enthusiasm that Task Force
activities have generated and finding
ways to continue such efforts as the
Task Force ends its three years.
When members of the Task Force
gave a presentation at a national meeting
for senior academic officers last fall,
the document aroused considerable interest.
A copy is available for all faculty
to peruse in the Faculty Conference
Room, second floor, Hunter Library.
Although the Task Force recognized
that the document contained information
that would be useful to the faculty,
members felt that another format and
additional material would make that
information even more useful. The
decision was made to go with a "field
guide to teaching the WCU student," a
handy booklet that would summarize
Task Force members are: (from left, firs t row) Scott Higgins, Health Serv ices Management arid Su pervision; Jane
Hall, Home Economics; Elizab eth Addison, Instru ctional Services; Jim Addison, En glish; (second row) Fran k
Prochaska, Chemistry and Physics ; Michael Dougherty (chairman), Human Services; John Wade, Economics and
Finance; Judith Stillion, Academic Affairs; and Mary Anne N ixon, Administrative Services. (Not pictured, J.C.
Alexander, Arts and Sciences; Wilburn Hay den, Social Work; and Mil Clark, Education and Psychology.)
the findings on effective teaching
behaviors and offer, as well, some
information on the typical WCU
student and faculty member.
And thus—after two years of looking
at scholarship by others—the Task
Force finds itself doing its first original
research. A half-dozen questions have
been developed, and selected faculty
and students will be interviewed in the
next month or so. People will be asked
to recall a special day in class—or a
special class overall—and to identify
specific teaching behaviors that made it
special. Students will be involved in the
interviewing of other students, faculty
in the interviewing of faculty.
The document and field guide will be
the focus of a presentation by Task
Force members at the National Seminar
on Successful College Teaching sponsored
by the University of Florida in March.
Upcoming Events
Meanwhile, the Task Force has been
planning special events in which
faculty can learn from each other.
Three short seminars are scheduled for
February and a three-day "Celebration
of Teaching" for March.
On Monday, February 8, Bill Kane,
associate professor of management and
marketing, and Bruce Henderson,
associate professor of psychology, will
talk about their experience of peer
evaluation. At Kane's request, Henderson
spent twenty hours observing one
cont'd next page
1
People and places
• Duane Davis (Criminal Justice)
chaired a session on Excellence in
Criminal Justice Curriculum" at the
annual Southern Criminal Justice
Association meeting in Birmingham,
Ala., in October. He also presented a
paper entitled Executive Protection:
An Emerging Trend in Criminal Justice
Education and Training," which has
been accepted for publication in The
Justice Professional.
• James E. Dooley (vice-chancellor
for Development and Special Services)
has been appointed by the North
Carolina Association of Colleges and
Universities to serve a three-year term
on its Committee on the College
Student. The committee conducts a
variety of projects, including research
on different facets of college life related
to students. This year the committee
will focus on the effectiveness of adult-learner
programs from the perspective
of the adult learner.
• B.J. Dunlap (Management and
Marketing) will serve a one-year term
as president of the Association of
Graduate Business Directors, a 75-
member association of deans and
directors of graduate studies at institutions
primarily in the Southeast. The
organization's purpose is to provide a
forum for individuals who lead business
graduate schools, so they can keep their
business programs current and effective.
Dunlap has been secretary, treasurer,
and vice-president of the organization.
• Glenn Liming spoke at the joint
meeting of the American Physical
Society and the American Association
of Physics Teachers in Washington,
D.C., on January 28. His presentation
was entitled 'The Choice of Introductory
Physics Topics within the Context
of the Process Rather than the Content
of Physics."
• Laura Mann (Music) recently
conducted a three-day workshop,
sponsored by Tilyou Music Studios of
Niagara Fails, N.Y., dealing with
different pedagogical approaches in
teaching voice to different age groups.
Selected participants performed at a
master class recital, and Mann presented
her own program of vocal works,
illustrating the workshop's vocal
techniques. Mann was also a soloist at
Our Lady of the Rosary Cathedral on
Christmas morning in a concert of
nineteenth and twentieth century
Christmas music.
• Kirs ten Underwood (Reading Center)
performed a solo cello recital at the
Waynesville Public Library on January
24, a program sponsored by the Haywood
County Arts Council and the
Friends of the Library. The program
included works by Brahms, Vivaldi, and
Mendelssohn.
Task Force cont'd
of Kane's classes during the fall
semester. He had a list of things Kane
wanted him to watch for and the
freedom to talk to the students as well
as observe. (He now says he got as
much out of the experience as his
colleague did.) The two professors will
hold forth beginning at 3 p.m. in the
Faculty Conference Room. Refreshments
will be served.
On Friday, February 19, Jo Ann
Carland, assistant professor of accounting
and information systems, will give a
Sandwich Seminar on "Cognitive
Styles as Described by the Myers-Briggs
Type Indicator." The seminar will
begin at 12 noon and the presentation
will last about forty-five minutes. After
the presentation, participants who can
stay a little longer will be able to
determine their own "types," which are
based on Jungian psychology.
Andy LaTorre will present a second
Sandwich Seminar on Tuesday, February
23, beginning at 12 noon. His topic
will be "Creativity." In an experiential
presentation, he will demonstrate ways
to move from conveying information to
stimulating the higher levels of learning
described in Bloom's taxonomy. This
seminar will continue until 1:30 p.m.
All faculty are invited to bring a
lunch to the Sandwich Seminars and
enjoy the collegial interchange in the
Faculty Conference Room. Coffee and
tea will be prQvided.
The "Celebration of Teaching" will
begin Monday, March 21, with a
presentation by Joseph Lowman of the
Chapel Hill psychology faculty.
Lowman, whose research on characteristics
of distinguished teachers has
recendy appeared in a book, will speak
on "Emulating the Expert Teacher" at 3
p.m. in the Ramsey Center's Hospitality
Room. A reception will follow.
Other celebration events will include
Teaching Tips luncheons and a poster
session on teaching strategies and techniques.
Look for more information in
the March Task Force Newsletter.
Plans for Teaching Effectiveness
seminars like those held the past two
years in May are incomplete, pending
more information about available funds.
In January the Task Force held a reunion
and reception for past participants
and their deans and department heads.
The overflow crowd heard new faculty
discuss the benefits they derived from a
special seminar during the 1987 spring
break; participants in the May seminar
told about the progress they were making
on their action plans, and honors
faculty discussed their conclusions on
the direction of the honors program.
Michael Dougherty, chairman of the
Task Force, says, "The Task Force has
reached and influenced a large proportion
of the faculty. It's great to see
faculty from the various disciplines
talking with one another about their
teaching. Even though the Task Force
will finish its work at the end of this
semester, its momentum will take other
forms and continue to be a positive
influence on teaching effectiveness at
Western Carolina University."
- Elizabeth Addison
Instructional Services Office
February5, 1988 The Reporter
Campus events
PIANO RECITAL- Asheville pianist
DeWitt Tipton will present a program
of solo works in a recital Tuesday, February
9, at 8 p.m. in the Music-English
Recital Hall. The program will include
works by Chopin and Ravel. Tipton, a
graduate of the University of Illinois, is
a member of the music faculty at
UNC-A. He has performed widely
throughout the Southeast as pianist and
conductor. The concert is free and open
to the public.
VIDEOCONFERENCE - A special
videoconference for teachers on positive
approaches to discipline will be
held from 5-8:30 p.m. on Tuesday, February
9, in the Cherokee Room of the
University Center. There is no admission
charge. Western will be one of an
expected thirty-five to forty sites in the
U.S. participating in the satellite-transmitted
videoconference which features
Charles Wolfgang, co-author of the
recent Solving Discipline Problems:
Strategies for Classroom Teachers. The
program is co-sponsored by the School
of Education and Psychology, the
Office of Continuing Education and
Summer School, the University Media
Center, and Jackson County Schools. It
originates from the University of
Georgia's Center for Continuing
Education.
Hitting the ice
As temperatures go down, Ramsey Center's rink heats up
It's 7:00 on a Thursday night and
the ice skating rink is about to
open. Already a long line has
formed at the skate rental table
where students Mike Hanes of
Lexington and Jack Gimple of
Morganton are filling orders.
Within twenty minutes, the most
popular sizes (ladies' eight, men's
nine) are all rented. By 7:30 p.m.,
there are a hundred skaters on the
ice. Hayes thinks it's a slow night.
"Fridays and Saturdays we have
close to 200, " he says.
Since the rink opened for its
second season last month, skaters
of all ages—tots and teenagers to
couples and senior citizens—from
the local community and neighboring
towns have hit the ice, so
to speak. They spin and glide or
trip and skid before dozens of
spectators watching from outside
the rink or from a steady procession
of cars that pass by.
After a disappointing first
season plagued by weather and
equipment woes, the ice rink
made a spectacular comeback this year,
thanks to suitable cold temperatures
Sarah Kucharski, 7, daughter of Rich ard (Legal Counsel) and
Glenda Kucharski, takes a spin on the ice with Kirk Nelson, an
instructor at the Rams ey Center rink. Skating lessons were
offered by the Jackson County Recreation and Parks Departmen t.
Faculty publications
Paradis, Philip. "A Conversation with Brendan Galvin" (interview). Tar River
Poetry 27 ( 1987): 1-12.
. "William Towbridge's The Book of Kong" (review). Prairie Schooner 61
(Summer 1987): 121-123.
. "Lesson for the Day." Kansas Quarterly 19 (1987): 317.
. "What the Citizenry Knows." The Laurel Review 21 (Summ er 1987): 29-30.
. 'Tremor." The Three Rivers Poetry Journal 29/30 (1987): 52.
, "Pickerel." Pembroke 19 (1987): 154.
and the talents of an experienced ice
maintenance staff, according to Robert
Stewart, Ramsey Center director. For
the rink maintenance staff, Stewart
chose several students who grew up in
the lake regions up North and are
accomplished skaters.
Health experts say ice skating is an
excellent form of recreation for all ages.
IF YOU'RE GOING - Only four weeks
left. The rink is open to the public
nightly from 7-10 p.m. until March. For
information about rink availability for
special groups, call the Ramsey Center
at 227-7677. Rental skates are $1 a pair.
Tip: Lace your skates as tightly as
possible at the ankle, more loosely near
the top, leaving enough room to slip a
finger through.
The Reporter February 5, 1988
In China arid Thailand
Far East trip focuses on economics, education
Six members of the board of trustrees
and a member of The University of
North Carolina Board of Governors ,
along with three WCU administrators,
will return on Sunday, February 7, from
China and Thailand. The group made
the trip for a first-hand look at
Western's programs there.
Chancellor Myron L. Coulter and
Mrs. Coulter are leading the delegation,
invited by officials of Yunnan University
and the Yunnan Provincial Government
in China and the Ministry of
Education in Thailand.
Making the fourteen-day trip are
trustees Wallace N. Hyde, chairman of
NCCAT seminar topics range
from quilting to coastlines
The North Carolina Center for the
Advancement of Teaching (NCCAT)
has announced seminar dates and topics
for summer and fall 1988. Seminar
subjects include music, quilting, North
Carolina artists, the Cherokee Indian
nation, the Appalachian Mountains,
history and development of the North
Carolina coast, and a variety of others.
Kay S. Shapiro, director of teaching
services at the center, said schedules
have been mailed to regional education
centers, superintendents, principals,
school media specialists, alumni, and
others throughout the state.
Applications for the seminars are now
being accepted. Cutoff date is March 1.
In addition to regular seminars, special
sessions are scheduled for teacher/scholars
in residence during June, July, and
August, and during one week in
November.
NCCAT seminars are open to
outstanding public school teachers of
all grade levels and disciplines.
Seminar dates and topics are:
The Power of Ideas: A Socratic
Teaching Demonstration, July 5-9; The
Natural History of North Carolina,
June 19-July 3; The Pursuit of Happiness,
July 12-16; Escaping the Shadows:
Mexicans' Quest for Identity and
Survival, July 26-30; A Moment in
Time: Exploring the Work of North
Carolina Artists, August 1-6;
The Nature of the Beast: Defining
Public Education in America, August
7-13; Time and Remembrance, August
8-12; A Quilt in Time, September 12-
17; The Cherokee Nation: Beyond the
Trail of Tears, September 19-23;
Freeing the Inner Voice: A Musical Exploration,
September 26-30.
Our Founding Faiths: A Paideia
Seminar, October 10-14; Graveyard of
the Atlantic: Exploring the History,
Development, and Future of North
Carolina's Coastal Ecology, October
11-15; The Blue Ridge Experience:
Human Occupation of Ancient
Mountains, October 18-24;
Bridging Culture, October 25-29; The
Changing Family, November 6-8;
Japan: Modern Miracle of the Far East,
November 8-12; Oil, Islam, and the
Middle East, November 28-December
2; The Power of Metaphor: Education
as Story, December 6-10; Leadership,
Creativity, and Change, December 12-
17.
Applications are available from the
center. For additional information
about the seminars or about qualifications
for applicants, contact Shapiro at
227-7370.
NCCAT is located in Madison Hall.
A unit of The University of North
Carolina, it conducts a year-round
program of seminars for the state's
outstanding public school teachers.
the WCU board, John Q. Schell, Jr.,
and Stephen W. Woody, all of
Asheville; James Cooper of Cherokee;
Orville Coward of Sylva; and Deborah
Strum of Franklin.
Sylva attorney R. Phillip Haire was
named by the Board of Governors to
represent it on the trip. Others in the
party include Anthony A. Hickey, dean
of research and graduate studies, and
Ellerd Hulbert, director of international
instructional programs.
During the trip the delegation was to
meet with Chinese and Thai officials to
discuss economic and education
programs established during the last six
years with Western.
The group was scheduled to visit an
agribusiness project and management
college in Guangzhou (formerly
Canton), where Western has been
working for the last year to develop
trade and education ties.
The group also planned to visit
Yunnan University, with which
Western has had administrative and
faculty exchanges in biology, English,
mathematics, and business for six years.
In Bangkok, the WCU group was to
have discussed with Thai education
officials, and possibly officials from the
U.S. Agency for International Development
and U.S. Information Agency, an
ongoing project to convert thirty-six
teachers colleges to four-year comprehensive
institutions. The Thai colleges
need some 800 faculty members upgraded
with master's degrees or doctorates.
Before his departure, Coulter said
Western would propose that a relatively
small number come to WCU and other
UNC-system institutions to earn the
advanced degrees. They would become
the faculty at two graduate centers in
Thailand that would be established to
upgrade the other institutions.
Some trustees were accompanied on
the trip by their wives, but Hulbert,
who coordinated the trip, said the
trustees, their wives, and Mrs. Coulter
are not traveling at university expense.
The Reporter is published by the Offic e of Public Informa tion.
February 5, 1988 The Reporter
REPORTER A Weekly Newsletter
for the Faculty and Staff
of Western Carolina University
Cullowhee, North Carolina February 12,1988
Dynamic classes mark growing honors program
"I do not know where you got that
answer," says a young lady to Joe
Klerlein, professor of mathematics, in
his honors math class. Isomorphic
figures are the topic at hand, and
Klerlein has just drawn the solution to
one of last night's homework problems.
The student's comment leads to a vote
among the students on whether or not
Klerlein's answer is correct (it is). Eager
and animated, the class is clearly more
than interested in the subject and in
each other's ideas. In an honors class,
this is not an unusual day.
Established in the mid-1970s, the
university honors program is designed
for the student who discovers there's a
genuine delight in learning new things,
according to program director Karl
Nicholas. "Learning is fun and worth
doing in and of itself, and that's the
attitude we want to foster," he says.
Entering freshmen qualify for invitation
to the program by showing a
combined score of 1150 on the Scholastic
Aptitude Test (or 600 on either the
verbal or math section) or by placing in
the top ten percent of their high school
graduating class. Other freshmen who
have a quality point ratio (QPR) of 3.5
or better during the fall semester are
also invited to join. Honors students
must maintain a QPR of 3.0.
Now with a full-time enrollment of
eighty-nine students, five new faculty
additions, and five new general education
courses in its curriculum, the
honors program is on the move.
"More things covered in more
depth—that's my goal for an honors
class," says Joe Meigs, associate professor
of English, who teaches an honors
Joe Klerlein, professor of mathematics, explains his solutio n to a mathematical concepts problem to h is Math 101
honors class. Klerl ein is one of twelve perm anent members of th e honors facult y at Western serving eighty-nine
full-time honors students.
course in literary landmarks. "I want
more participation from the students. I
ask for more presentations. I want the
class to get to know each other."
Apparently that aim is at work
throughout the program. Honors students
are encouraged to challenge their
professors and each other in the
classroom, a fact contributing to the
program's continuing growth.
"They just don't spoon-feed you in
these classes," says a student in Meigs's
class. "You're given an idea and you go
research it. You learn it that way."
Another large portion of the
program's attraction for students,
according to Nicholas, is that it offers
"a place to hang out together, as well as
socials and speakers and the pleasure of
each other's company."
Honors faculty members agree that as
a unit an honors class assumes a larger,
more intense personality. In Nicholas's
colorful description, the students'
energetic curiosities "strike sparks"
against each other.
Nicholas says several ideas are in the
works for the future of the honors
program. There are plans to develop
team-taught "general-education-type
courses," incorporating material from
more than one discipline. An intensive
Western civilization course, for
example, might combine history with
other humanities. Each course would
span at least two semesters and would
earn participants nine to twelve hours
of credit.
In addition, Nicholas says, university
officials are looking into the possibility
of establishing a "living/learning
cont'd page 3
People and places
• Bill Anderson (History) was
recently appointed to the editorial
board of the Journal of Cherokee Studies
and the advisory board of the Museum
of the Cherokee Indian in Cherokee.
He also received one of thirty stipends
awarded by the Newberry Library of
Chicago to attend a recent conference
there. Anderson and his wife, Nina, are
the authors of Southern Treasures, a
book about buried and lost treasures in
the southern U.S. as well as natural
treasures such as gold, rubie
El dolor como logro colectivo: Una entrevista a Ítalo Latorre y Carolina Letelier de Pranas Chile
No full textEn esta entrevista luminosa y enriquecedora, Ítalo Latorre Gentoso y Carolina Letelier Astorga —integrantes de Pranas Chile y referentes de las prácticas narrativas latinoamericanas— comparten sus perspectivas sobre el dolor, esa experiencia tan humana que tantas veces intentamos comprender, evitar o esconder. Las preguntas se despliegan como caminos hacia la reflexión y el cuidado relacional: ¿qué es el dolor?, ¿por qué tememos mostrarlo?, ¿por qué deseamos silenciarlo?, ¿cómo acompañamos a otras personas en su dolor?, ¿qué papel juega la sociedad en el sostenimiento —o en el silenciamiento— del dolor? Entre palabras tejidas con ternura, experiencia y profundidad, Ítalo y Carolina expresan que el dolor no es un problema, mucho menos algo individual, sino una manifestación de que algo que nos es valioso ha sido vulnerado. Nos comparten su visión del dolor como un logro colectivo, como una forma de protesta y de denuncia ante el avasallamiento de aquello que nos importa. El diálogo se convierte en un espacio político y de pensamiento compartido que nos invita a mirar el dolor desde la ética del cuidado, a través de preguntas que abren sentido: ¿por qué dolemos?, ¿qué de lo que valoramos está siendo vulnerado?, ¿con quiénes podemos resonar en nuestro dolor?, ¿a quién le conviene que dejemos de doler? Esta entrevista abre cuestionamientos sobre lo que pensamos del dolor y nos invita a honrar su sabiduría implícita. Como dice la entrevistadora, las palabras de Ítalo y Carolina son “un curita rebelde en el corazón”; deseamos que también lo sean, al menos un poco, para quienes lean o escuchen esta entrevista
Valorization of cannabis waste fibres for the reinforcement of rammed-earth walls
No full textThis research evaluates the compression strength and durability of rammed earth reinforced with cannabis fibres derived from waste in the medicinal cannabis industry. The results indicate that samples with fibres exhibit higher compression strength and post-failure elastic characteristics, resisting collapse for 8 minutes longer than those without fibres. Subsequently, this thesis develops a circular economy model involving three companies in the Colombian municipality of Barichara, Santander, to identify barriers, opportunities, and strategies to optimize waste management in the cannabis industry
sj-docx-2-hol-10.1177_09596836231225722 – Supplemental material for Population dynamics and cultural niche construction during the Late Holocene in a mediterranean ecosystem (central Chile, 32°S−36°S)
No full textSupplemental material, sj-docx-2-hol-10.1177_09596836231225722 for Population dynamics and cultural niche construction during the Late Holocene in a mediterranean ecosystem (central Chile, 32°S−36°S) by Carolina Godoy-Aguirre, Matías Frugone-Álvarez, Eugenia M. Gayo, Roberto Campbell, Mauricio Lima, Antonio Maldonado and Claudio Latorre in The Holocene</p
Special waste valorization and renewable energy generation under a circular economy: Which priorities?
No full textThe European Union regulation for emissions from waste incinerators had a significant evolution in the last 20 years. That allowed reaching a clear improvement in the environmental performances of the plants, synchronized with specific requests of compliance of the more and more stringent limits set at regulatory level. Today the main questions for the sector in Europe seem mostly related to the role of waste to energy plants in a scenario of circular economy and to the role of those plants in the generation of energy only in part renewable. It seems that the topic of the local environmental and health impact has become out to date in European Union. In spite of that, a big question remains on the suitability of the present regulation for the future of the sector, including co-incineration by the use of Secondary Recovered Fuel from waste as substitute of coal in cement works. The present article analyzes an aspect that should be a priority higher than the concept of circular economy and energy generation. Indeed, a question remains on the criticalities that could be present in the European Union for under-estimation of the role of heavy metals, in spite of the evolution of the regulation. If we look at the experience of the University of Trento (where the Author worked in various research projects since 2003) the last decade has been characterized by recurrent warnings from that University about the excessive simplification of the regulation in case of heavy metals. As an example, in case of waste incineration, a set of heavy metals are managed by summing their concentrations to be compared as sum to the regulation limit: no valorization of the specific knowledge on toxicity is made. In order to point out the consequences of this simplification, a few case-studies demonstrating a potential criticality on the role of CrVIare discussed. A control methodology integrating the present one is discussed in this article, to propose a solution suitable to avoid under-estimations of human exposure to heavy metals from incineration and co-incineration. This approach is particularly important when special waste is combusted as the composition of the input can present heavy metals concentrations higher than municipal solid waste
RecA and RadA Proteins of Brucella abortus Do Not Perform Overlapping Protective DNA Repair Functions following Oxidative Burst
No full textVery little is known about the role of DNA repair networks in Brucella abortus and its role in pathogenesis. We investigated the roles of RecA protein, DNA repair, and SOS regulation in B. abortus. While recA mutants in most bacterial species are hypersensitive to UV damage, surprisingly a B. abortus recA null mutant conferred only modest sensitivity. We considered the presence of a second RecA protein to account for this modest UV sensitivity. Analyses of the Brucella spp. genomes and our molecular studies documented the presence of only one recA gene, suggesting a RecA-independent repair process. Searches of the available Brucella genomes revealed some homology between RecA and RadA, a protein implicated in E. coli DNA repair. We considered the possibility that B. abortus RadA might be compensating for the loss of RecA by promoting similar repair activities. We present functional analyses that demonstrated that B. abortus RadA complements a radA defect in E. coli but could not act in place of the B. abortus RecA. We show that RecA but not RadA was required for survival in macrophages. We also discovered that recA was expressed at high constitutive levels, due to constitutive LexA cleavage by RecA, with little induction following DNA damage. Higher basal levels of RecA and its SOS-regulated gene products might protect against DNA damage experienced following the oxidative burst within macrophages. Originally published Journal of Bacteriology, Vol. 188, No. 14, July 200
sj-xlsx-1-hol-10.1177_09596836231225722 – Supplemental material for Population dynamics and cultural niche construction during the Late Holocene in a mediterranean ecosystem (central Chile, 32°S−36°S)
No full textSupplemental material, sj-xlsx-1-hol-10.1177_09596836231225722 for Population dynamics and cultural niche construction during the Late Holocene in a mediterranean ecosystem (central Chile, 32°S−36°S) by Carolina Godoy-Aguirre, Matías Frugone-Álvarez, Eugenia M. Gayo, Roberto Campbell, Mauricio Lima, Antonio Maldonado and Claudio Latorre in The Holocene</p
Crítica del Libro "Ética para Máquinas", de José Ignacio Latorre, Ariel, Barcelona, 2019, 320 págs
No full textActualmente predomina la acción de los seres humanos en relación con las máquinas. Latorre propone, partiendo de un recuento de la evolución de las máquinas, un escenario ficticio donde las máquinas han superado al ser humano especialmente, en su actividad neuronal y de pensamiento. El autor discurre sobre cuestiones de moral humana aplicada en máquinas, a fin de llevar a una reflexión respecto del avance de la tecnología, la inteligencia artificial y la relación de los humanos con este medio.Nowadays, human action prevails over their relation with machines. Latorre, from reminding machines evolution, proposes a fictional scenario where machines have overcome humans, especially in neuronal activity and thinking. This author reasons on human moral questions applied to machines, in order to bring into a consideration on technology and artificial intelligence advance, and human relationship with this environment
Crítica del Libro "Ética para Máquinas", de José Ignacio Latorre, Ariel, Barcelona, 2019, 320 págs
No full textActualmente predomina la acción de los seres humanos en relación con las máquinas. Latorre propone, partiendo de un recuento de la evolución de las máquinas, un escenario ficticio donde las máquinas han superado al ser humano especialmente, en su actividad neuronal y de pensamiento. El autor discurre sobre cuestiones de moral humana aplicada en máquinas, a fin de llevar a una reflexión respecto del avance de la tecnología, la inteligencia artificial y la relación de los humanos con este medio.Nowadays, human action prevails over their relation with machines. Latorre, from reminding machines evolution, proposes a fictional scenario where machines have overcome humans, especially in neuronal activity and thinking. This author reasons on human moral questions applied to machines, in order to bring into a consideration on technology and artificial intelligence advance, and human relationship with this environment
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