1,721,042 research outputs found
Re-writing the natural history of pain and related symptoms in the joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type
No full textJoint hypermobility syndrome (JHS) and Ehlers-Danlos syndrome, hypermobility type (EDS-HT) are two clinically overlapping connective tissue disorders characterized by chronic/recurrent pain, joint instability complications, and minor skin changes. Fatigue and headache are also common, although are not yet considered diagnostic criteria. JHS/EDS-HT is a unexpectedly common condition that remains underdiagnosed by most clinicians and pain specialists. This results in interventions limited to symptomatic and non-satisfactory treatments, lacking reasonable pathophysiologic rationale. In this manuscript the fragmented knowledge on pain, fatigue, and headache in JHS/EDS is presented with review of the available published information and a description of the clinical course by symptoms, on the basis of authors' experience. Pathogenic mechanisms are suggested through comparisons with other functional somatic syndromes (e.g., chronic fatigue syndrome, fibromyalgia, and functional gastrointestinal disorders). The re-writing of the natural history of JHS/EDS-HT is aimed to raise awareness among clinical geneticists and specialists treating chronic pain conditions about pain and other complications of JHS/EDS-HT. Symptoms' clustering by disease stage is proposed to investigate both the molecular causes and the symptoms management of JHS/EDS-HT in future studies. © 2013 Wiley Periodicals, Inc.Joint hypermobility syndrome (JHS) and Ehlers–Danlos syndrome,
hypermobility type (EDS-HT) are two clinically overlapping
connective tissue disorders characterized by chronic/
recurrent pain, joint instability complications, and minor skin
changes. Fatigue and headache are also common, although are
not yet considered diagnostic criteria. JHS/EDS-HT is a unexpectedly
common condition that remains underdiagnosed by
most clinicians and pain specialists. This results in interventions
limited to symptomatic and non-satisfactory treatments, lacking
reasonable pathophysiologic rationale. In this manuscript the
fragmented knowledge on pain, fatigue, and headache in JHS/
EDS is presented with review of the available published information
and a description of the clinical course by symptoms, on
the basis of authors’ experience. Pathogenic mechanisms are
suggested through comparisons with other functional somatic
syndromes (e.g., chronic fatigue syndrome, fibromyalgia, and
functional gastrointestinal disorders). The re-writing of the
natural history of JHS/EDS-HT is aimed to raise awareness
among clinical geneticists and specialists treating chronic pain
conditions about pain and other complications of JHS/EDS-HT.
Symptoms’ clustering by disease stage is proposed to investigate
both the molecular causes and the symptoms management of
JHS/EDS-HT in future studie
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Certified Information Access
No full textCertified Information Access (CIA) primitive allows a user to obtain answers to database queries in a way that she can verify the correctness of the received information. The database owner answers a query by providing the information matching the query along with a proof that such information are consistent with the actual content of the database. Current solutions to this problem require a computationally intensive setup phase. We describe two secure distributed implementations of a CIA service. In the first one, the database owner distributes the evaluation of a computation intensive function (e.g., exponentiations) among a set of untrusted peers and locally reconstructs the result of such an evaluation. In the second one, we propose a protocol for securely outsourcing the whole computation of the data structures used in the implementations of the CIA primitive. In this case, the main issue to be considered is the need of guaranteeing on the one hand the confidentiality of the database contents and, on the other hand, the correctness and soundness of the answers obtained by the users. We argue that classical cryptographic primitives are not sufficient for our purposes and we introduce a new primitive, the Verifiable Deterministic Envelope, that may be of independent interest
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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