87,432 research outputs found
IlTratatello delle indulgentie de Terra Sanctasecondo il ms. 1106 della biblioteca Augusta di Perugia: edizione e note linguistiche
No full textThe research focused on the study of ms. 1106 (= F), one of the witnesses of the Treaty
of the Holy Land and the East of the Franciscan missionary Francesco Suriano (Venice
1450-Assisi 1529ca.).
The main objective of research was the realization of the scientific edition of F (yet
unpublished) and detailed analysis of the language of the text.
The work involved, at first, the transcription of 157 cc. of the codex, produced in the
monastery of St. Mary Monteluce of Perugia and now kept in the Augusta Library of
Perugia. Secondly, the realization of the description of manuscript; the results of the
comparison between F and contemporaries codices of Monteluce; handwriting analysis
of F; the study of textual tradition; a comprehensive inventory of mss. of Monteluce and
S. Lucia di Foligno; a brief biography of the author; a collation of F with other witnesses
yet known of the Treaty, another ms. (P) and the princeps (B).
Finally, we have conducted in deep linguistics investigations on F, which made
possible to point out, next to strong local aspects consistent with the area of origin of
the ms., Umbria, other elements which are attributable to its complex layering, to explain
the articulated composition story of the text. In particular, there were (mainly in the
phonetic) features that tracked back to the language of northern Italy, to explain the
venetian origin of Suriano
Bielli Caria, Pinnelli Antonella, Russo Aldo — Fecondità e lavoro della donna. Un'indagine, in quattro zone tipiche italiane, con un'introduzione di Nora Federici
No full textF. P. Bielli Caria, Pinnelli Antonella, Russo Aldo — Fecondità e lavoro della donna. Un'indagine, in quattro zone tipiche italiane, con un'introduzione di Nora Federici. In: Population, 30ᵉ année, n°3, 1975. p. 638
Vagus nerve stimulation increases neurotrophins gene expression and alters cell proliferation in the rat hippocampus
No full textVagus nerve stimulation (VNS) is effective in patients with treatment-resistant epilepsy. More recently, VNS has been ap- proved for treatment-resistant depression; nevertheless, the molec- ular mechanism(s) underlying its therapeutic action remains un- clear. In light of the proven anticonvulsant properties of VNS, its modulation of neurochemical systems implicated in major de- pression and impact on neuronal functional activity and plasticity, we tested the possibility that VNS could promote the synthesis of neurotrophic factors (BDNF, bFGF and NGF) that promote survival, maintenance and proliferation of neuronal cells, in the rat brain. Moreover, we investigate whether VNS could interfere with neurogenesis in the hippocampal dentate gyrus.
RNase protection assay revealed that acute VNS increases the abundance of BDNF and bFGF mRNAs in the hippocampus, and do not significantly alters the abundance of NGF mRNA. Immunohistochemical studies demonstrate that VNS alters cell proliferation and neurogenesis in dentate gyrus, as demonstrated by the double labeling with specific antibodies for the nuclear neuronal protein NeuN and BrdU.
Our results suggest that VNS could trigger neuronal plastic changes and demonstrate that such stimulation induced an increase in the gene expression of BDNF and bFGF in the rat hippocampus. These increases in growth factors were associated with a disrup- tion of cell proliferation and neurogenesis process in the granule cell layer of the dentate gyrus. These new findings contribute to elucidate the molecular mechanisms underlying the action of VNS, a new therapeutic tool for the treatment of epilepsy and depression.
References
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Marrosu, F., Santoni, F., Puligheddu, M., Barberini, L., Maleci, A., Ennas, F., Mascia, M., Zanetti, G., Tuveri, A., Biggio G., 2005. Increase in 20−50 Hz (gamma frequencies) power spectrum and synchronization after chronic vagal nerve stimulation. Clin Neurophysiol 116, 2026−36. Marrosu, F., Serra, A., Maleci, A., Pulicheddu, M., Biggio, G., Piga., M., 2003. Correlation between GABAA receptor density and va- gus nerve stimulation in individuals with drug-resistant partial epilepsy. Epilepsy Res 55, 59−70.
Palma, E., Torchia, G., Limatola, C., Trettel, A., Arcella, A., Can- tore, G., Di Gennaro, G., Manfredi, M., Esposito, V., Quarato, P.P., Miledi, R., Eusebi, F., 2005. BDNF modulates GABAA receptors microtransplated from thehuman epileptic brain to Xenopus oocites. Proc Natl Acad Sci USA 102, 1667–1672
Towards a traceable divider for composite voltage waveforms below 1 kV
No full textIn the framework of the European Project 19NRM07 HV-com2 supporting the standardization in high-voltage testing with composite and combined wave shapes, a divider to employ in a test set-up for validation of electrical devices submitted to composite voltages below 1 kV has been developed at the Istituto Nazionale di Ricerca Metrologica (INRIM) and currently is under extensive testing. After a simulation stage, an available divider has been modified to comply with the IEC 60,060 requirements in terms of step response and scale factor. To be suitably fast in replying to step voltages, an adjustment of the components of the low-voltage arm has been made. The divider has been calibrated with traceability to the relevant INRIM National Standards and characterized exploiting its scale factor at different voltages and frequencies. The divider has been then inserted in a set-up with a sinusoidal generator, an impulse generator and coupling–blocking elements to carry out tests at low voltages (below 1 kV) with single voltages. In these tests, the divider showed a satisfactory attitude as converting device and its scale factor is traceable with suitable uncertainty
Outcome evaluation of school-based alcohol prevention : a European multi-centric trial (EU-Dap study)
No full textBackground: Curricula aiming at preventing substance use are widespread in European schools, without formal evaluation of their effectiveness. Promising programmes based on the Comprehensive Social Influence (CSI) model have never been evaluated in Europe.Aim: The overall aim of this thesis was to advance knowledge on the effectiveness of school-based best practice programmes on adolescents’ alcohol use, as well as to elucidate the possible pathways to behavioural changes.Methods: A cluster randomized controlled trial was carried out in 143 schools from seven European countries, involving 7079 students 12-14 years of age. Schools were randomly assigned to either control or to a 12-session standardised curriculum based on the CSI model, taught by trained teachers. Randomisation was blocked within socioeconomic levels of the school neighbourhood. Students were surveyed through a self-completed anonymous questionnaire at baseline, 6 (short term) and 18 (medium term) months thereafter. The effect of the programme on alcohol-related cognitive factors (intention to drink and to get drunk, knowledge on alcohol-related effects, skills to resist pressure to drink alcohol, normative beliefs, expectations and risk perceptions concerning alcohol) was analysed at the short term follow-up, on alcohol consumption and problematic use at the medium term. Additionally, the effect of some class characteristics on programme implementation was studied using the intervention classes as units of analysis. Given the hierarchical structure of the data all data analyses were carried out using multilevel models.Results: The programme was associated with decreased positive expectations towards alcohol (odds ratio (OR)=0.81) and perception of peer drinking (OR=0.79), as well as with increased resistance skills against pro-alcohol pressures (OR=1.21) and knowledge (OR=2.25) at the short term follow-up. One year later the programme was associated with a decreased odds of reporting episodes of drunkenness (OR=0.79) and alcohol-related problematic behaviours (OR=0.78). There was no reduction in the frequency of alcohol use but non-drinkers and occasional drinkers at baseline progressed towards frequent drinking less often in the intervention group than in the control group. Associations were stronger among students from schools located in area of low socio economic level. Some characteristics of the class predicted the level of programme implementation: prevalence of substance use was associated with a decreased odds of implementing the programme in its entirety (OR=0.81), while students’ connectedness was associated with an increased odds of teachers using role-play (OR=1.52).Conclusions: School curricula based on the CSI model can modify cognitive factors for alcohol use and reduce occurrence of drunkenness and alcohol-related behavioural problems among students from European Countries. These programmes are likely to be particularly useful in socially disadvantaged areas. There was support for the hypothesis that resistance skills, norm perception and positive expectations may mediate the effect of school prevention on behavioural outcomes. Specific organizational strategies such as teachers’ training in class management techniques may be integral to the provision of this type of programmes, in order to improve their implementation.List of scientific papersI. Caria MP, Faggiano F, Bellocco R, Galanti MR. Effects of a school-based prevention program on European adolescents' patterns of alcohol use. J Adolesc Health. 2011; 48:182-8. https://doi.org/10.1016/j.jadohealth.2010.06.003 II. Caria MP, Faggiano F, Bellocco R, Galanti MR. The influence of socioeconomic environment on the effectiveness of alcohol prevention among European students: a cluster randomised controlled trial. BMC Public Health. 2011; 11:312. https://doi.org/10.1186/1471-2458-11-312 III. Caria MP, Faggiano F, Bellocco R, Vigna-Taglianti F, Galanti MR. Effects of a school-based prevention programme on European adolescents’ intentions, perceptions and expectations towards alcohol drinking. [Manuscript]IV. Caria MP, Faggiano F, Bellocco R, Galanti MR. Classroom characteristics and implementation of a substance use prevention curriculum in European countries. European Journal of Public Health. [Accepted] https://pubmed.ncbi.nlm.nih.gov/23334820 </p
Un lavoro remoto di qualità: condizioni e organizzazione
No full textObiettivo del contributo è avanzare alcune ipotesi interpretative dei diversi atteggiamenti che i lavoratori manifestano rispetto al lavoro remoto. Utilizzando i dati Inapp della V Indagine sulla Qualità del lavoro
(QdL) del 2021, che consentono di analizzare approfonditamente le caratteristiche dei lavoratori coinvolti o meno nel lavoro remoto, si esplora il rapporto tra lavoro remoto, tecnologie utilizzate, condizioni
di lavoro e alcuni aspetti organizzativi dell’attività lavorativa, facendo riferimento al paradigma multidimensionale e multidisciplinare della qualità del lavoro
Un consolidamento antico con inzeppature metalliche in un paramento lapideo a Iasos (Caria)
No full textEl artículo analiza una consolidación antigua en una pared de la gran terma en Iasos de Caria. El análisis se basa en la observación del uso inusual de elementos de hierro, insertados abundantemente en las juntas de una pared del caldarium. La inspección y estudio de las características constructivas del muro permitieron identificar un deterioro del revestimiento. Este último, formado por grandes y pesados bloques apenas esbozados y no unidos al núcleo del muro, se desprendió quizás por efecto de un terremoto. El uso de la cuña de hierro para crear contraste entre las piedras de un paramento constituía una solución óptima para consolidar la mampostería sin tener que desmontar todo el revestimiento.

[it] L’articolo analizza un consolidamento antico su una parete delle grandi terme a Iasos di Caria. L’analisi si basa sull’osservazione dell’impiego inconsueto di elementi di ferro, inseriti in abbondanza nei giunti di una parete del caldarium. Il rilievo e lo studio delle caratteristiche costruttive del muro hanno condotto all’identificazione di un dissesto del paramento. Quest’ultimo, formato da grandi e pesanti blocchi appena sbozzati e non ammorsati al nucleo della muratura in conglomerato, si distaccò forse per effetto di un terremoto. L’impiego di zeppe di ferro per creare contrasto tra le pietre di un paramento dissestato, costituiva una soluzione ottimale per consolidare la muratura senza dover smontare l’intero paramento.</jats:p
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
The Effect of Thermal Stresses on the Electrical Resistance of Crimped Connections
No full textCables headed with crimped lugs are frequently used in test laboratories in temperature rise tests carried out to validate electrical devices. The increase in the electrical resistance of the crimped connections can cause high dissipation of power and heat during these tests, impairing their outcome. This work evaluates the effect of thermal stresses on the resistance and on the dissipated power of crimped connections. This resistance was found to be more sensitive to thermal stresses than to mechanical ones analysed in a previous work. A limit of the dissipated power from crimped connections during temperature rise tests was estimated to be about 4 W corresponding to a crimp resistance of 24 mu ohm for tests made at 400 A. Respecting these limits could avoid unnecessary rejections of equipment under test
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