561 research outputs found
A spectrofluorometric analysis to evaluate transcutaneous biodistribution of fluorescent nanoparticulate gel formulations
No full textThe investigation of the absorption of drug delivery systems, designed for the transport of therapeutic molecules inside the body, could be relatively simplified by the fluorophore association and tracking by means of bio-imaging techniques (i.e., optical in vivo imaging or confocal and multiphoton microscopy). However, when a fluorescence signal comes out from the skin, its specific detection can be problematic. Skin high autofluorescence can hinder the observation of administered exogenous fluorophores conjugated to drug delivery systems, making it more challenging to detect their biodistribution. In the present study, we have developed a method based on the spectrofluorometric analysis of skin samples to discriminate the fluorescent signal coming from administered fluorescent molecules from the background. Moreover, we gave a semi-quantitative evaluation of the signal intensity. Thus, we distinguished two gel formulations loading the fluorophore rhodamine B (called GEL RHO and GEL SLN-RHO). The two formulations of gels, one of which containing solid lipid nanoparticles (GEL RHO-SLN), were administered on skin explants incubated in a bioreactor, and the penetration was evaluated at different time points (2 and 6 hours). Cryostatic sections of skin samples were observed with confocal laser scanning microscopy, and a spectrofluorometric analysis was performed. Significantly higher signal intensity in the samples administered with SLN-RHO GEL, with a preferential accumulation in the hair bulbs, was found. Reaching also the deeper layers of the hair shaft after 6 hours, the solid lipid nanoparticles thickened with polymer represent a suitable drug delivery system for transcutaneous administration
Correction to: Size‐Dependent Enforcement, Tax Evasion and Dimensional Trap
No full textThe article “Size‐Dependent Enforcement, Tax Evasion and Dimensional Trap”, written by Raffaella Coppier, Elisabetta Michetti and Luisa Scaccia, was originally published electronically on the publisher’s internet portal on 05 July 2023 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 24 February 2024 to © The Author(s) 2024 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made
Viral Encephalopathy and Retinopathy in groupers (<it>Epinephelus</it> spp.) in southern Italy: a threat for wild endangered species?
No full textAbstract Background Betanodaviruses are the causative agents of Viral Encephalopathy and Retinopathy (VER). To date, more than 50 species have proved to be susceptible and among them, those found in genus Epinephelus are highly represented. Clinical disease outbreaks are generally characterized by typical nervous signs and significant mortalities mainly associated with aquaculture activities, although some concerns for the impact of this infection in wild fish have been raised. In this study, the authors present the first documented report describing an outbreak of VER in wild species in the Mediterranean basin. Case presentation In late summer - early winter 2011 (September-December), significant mortalities affecting wild Dusky grouper (Epinephelus marginatus), Golden grouper (Epinephelus costae) and European sea bass (Dicentrarchus labrax) were reported in the municipality of Santa Maria di Leuca (Northern Ionian Sea, Italy). The affected fish showed an abnormal swimming behavior and swollen abdomens. During this epizootic, five moribund fish showing clear neurological signs were captured and underwent laboratory investigations. Analytical results confirmed the diagnosis of VER in all the specimens. Genetic characterization classified all betanodavirus isolates as belonging to the RGNNV genotype, revealing a close genetic relationship with viral sequences obtained from diseased farmed fish reared in the same area in previous years. Conclusion The close relationship of the viral sequences between the isolates collected in wild affected fish and those isolated during clinical disease outbreaks in farmed fish in the same area in previous years suggests a persistent circulation of betanodaviruses and transmission between wild and farmed stocks. Further investigations are necessary to assess the risk of viral transmission between wild and farmed fish populations, particularly in marine protected areas where endangered species are present.</p
In vivo and ex vivo biodistribution of solid lipid nanoparticles
No full textThe in vivo and ex vivo biodistribution of solid lipid nanoparticles has been studies by a multimodal imaging approac
Elisabetta I come Cinzia: Una regina e il suo oceano
No full textThe defeat of the Spanish Armada in the Channel in 1588 turned ‘a weak and feeble woman’ into one of the most relevant characters of late 16th-century European history: Elizabeth I, the Tudor Queen, was considered a semi-divine creature whom the myth, by comparing her to Moon goddesses like Diana and Cinthia, had made known as Semper Eadem.
The identification of the queen with Cinthia became more and more evident after the events occurred in 1588, when she was hailed as the moon goddess par excellence in a series of texts written by her contemporaries. It was in that period, the last decades of the 16th century, that Sir Walter Ralegh, courtier, poet and seaman, wrote The Poems to Cynthia: a collection of short poems where Elizabeth I, the lady of the seas, is addressed as his beloved. The role of Elizabeth as Cinthia is evident above all in Ralegh’s Last Book of the Ocean to Cynthia, an unfinished poem where the author, desperate for being in disgrace, appeals to her clemency and addresses her as the empress of the ocean.La sconfitta della flotta spagnola nelle acque della Manica nel 1588 trasformò una donna sola e fragile in una delle figure più rilevanti della storia europea di fine XVI secolo: Elisabetta I Tudor divenne per i suoi sudditi una creatura semidivina che il mito, accostandola alle divinità lunari Diana e Cinzia, avrebbe consegnato alla Storia come Semper Eadem.
Pur essendo evidente già nei primi tempi del suo regno, l’identificazione della sovrana con Cinzia, la dea che governa i mari e i corsi d’acqua, si fa ancora più evidente dopo il 1588, quando si assiste ad una fioritura di testi che esaltano Elisabetta I come la dea lunare per eccellenza.
Sempre in quegli anni di fine XVI secolo, Sir Walter Ralegh compone The Poems to Cynthia: letterato, cortigiano e uomo di mare, Ralegh dedicherà il suo amore ad Elisabetta come Cinzia, signora dei mari. Il legame tra Elisabetta e l’oceano è soprattutto evidente in Last Book of the Ocean to Cynthia, un poemetto incompiuto in cui il poeta, caduto in disgrazia, riunisce sotto il nome di Cinzia, la donna e la regina, l’amante e la dea, trasformando così Elisabetta in dea e imperatrice dei mari
Elisabetta I come Cinzia. Una regina e il suo oceano.
No full textLa sconfitta della flotta spagnola nelle acque della Manica nel 1588 trasformò una donna sola e fragile in una delle figure più rilevanti della storia europea di fine XVI secolo: Elisabetta I Tudor divenne per i suoi sudditi una creatura semidivina che il mito, accostandola alle divinità lunari Diana e Cinzia, avrebbe consegnato alla Storia come Semper Eadem. Pur essendo evidente già nei primi tempi del suo regno, l’identificazione della sovrana con Cinzia, la dea che governa i mari e i corsi d’acqua, si fa ancora più evidente dopo il 1588, quando si assiste ad una fioritura di testi che esaltano Elisabetta I come la dea lunare per eccellenza. Sempre in quegli anni di fine XVI secolo, Sir Walter Raleigh compone ‘The Poems to Cynthia’: letterato, cortigiano e uomo di mare, Raleigh dedicherà il suo amore ad Elisabetta come Cinzia, signora dei mari. Il legame tra Elisabetta e l’oceano è soprattutto evidente in ‘Last Book of the Ocean to Cynthia’, un poemetto incompiuto in cui il poeta, caduto in disgrazia, riunisce sotto il nome di Cinzia, la donna e la regina, l’amante e la dea, trasformando così Elisabetta in dea e imperatrice dei mari.The defeat of the Spanish Armada in the Channel in 1588 turned ‘a weak and feeble woman’ into one of the most relevant characters of late 16th-century European history: Elizabeth I, the Tudor Queen, was considered a semi-divine creature whom the myth, by comparing her to Moon goddesses like Diana and Cinthia, had made known as Semper Eadem. The identification of the queen with Cinthia became more and more evident after the events occurred in 1588, when she was hailed as the moon goddess par excellence in a series of texts written by her contemporaries. It was in that period, the last decades of the 16th century, that Sir Walter Raleigh, courtier, poet and seaman, wrote ‘The Poems to Cynthia’: a collection of short poems where Elizabeth I, the lady of the seas, is addressed as his beloved. The role of Elizabeth as Cinthia is evident above all in Raleigh’s ‘Last Book of the Ocean to Cynthia’, an unfinished poem where the author, desperate for being in disgrace, appeals to her clemency and addresses her as the empress of the ocean
Praxiphanes of Mytilene (called 'of Rhodes'). The Sources, Text and Translation
No full textNuova edizione dei frammenti di Prassifane di MItilene, detto di Rodi, con traduzione e note. Prassifane era uno dei filosofi di età ellenistica implicato in ruoli anche pubblici in merito ai quali abbiamo segnali di onori ricevuti (cittadinanza e prossenia). I frammenti superstiti permettono di ricostruire la personalità di un filosofo peripatetico, allievo di Teofrasto, che pur avendo acquisito fama come 'primo grammatico' ed essersi occupato di critica letteraria, di poeti, di poetica e di 'storia', non lasciò da parte interessi di etica e probabilmente di fisica. Importante la sua attività a Rodi, nel pieno III sec. a.C., in un periodo nel quale l'isola rivestì un ruolo particolarmente rilevante dal punto di vista politico, economico e culturale per il mondo ellenico.New Critical Edition of the sources related to Praxiphanes of Mytilene, called of Rhodes' (3rd BC), a Peripatetic philosopher, pupil of Theophrastus, whose entire works are lost. The new collection of fragments shows that he was a philosopher involved in public life, called 'first grammarian' and author of works on literary critics, on poetics, on poets, on history, on ethics and physics. He lived and worked in Rhodes in a special period when this island was an important economic, political and cultural centre of the Hellenic world
Embodied Environmental and Social Impacts: A Regionalised Sectoral Method for Low-Carbon Construction Materials in Italy
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Open AccessArticle
Embodied Environmental and Social Impacts: A Regionalised Sectoral Method for Low-Carbon Construction Materials in Italy
by Elisabetta Palumbo 1,* andFrancesco Pomponi 2ORCID
1
Department of Engineering and Applied Science (DISA), University of Bergamo, 24129 Bergamo, Italy
2
York School of Architecture, University of York, York YO10 5DD, UK
*
Author to whom correspondence should be addressed.
Sustainability 2025, 17(21), 9797; https://doi.org/10.3390/su17219797
Submission received: 25 September 2025 / Revised: 26 October 2025 / Accepted: 28 October 2025 / Published: 3 November 2025
(This article belongs to the Topic Construction Project Management and Infrastructure Sustainability)
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Abstract
The decarbonisation of the built environment has increased reliance on Environmental Life Cycle Assessment (E-LCA) to evaluate the impacts of construction materials. However, social aspects—particularly those affecting workers—remain underexplored. This study presents a regionalised approach to support socially and environmentally informed decision-making in the Italian construction sector. For this purpose, we have integrated worker health and safety indicators into the E-LCA of two representative building products assessed across key life cycle stages. These indicators are incorporated into the evaluation of Global Warming Potential (GWP), thus serving as a decision-support tool during the design phase. From a design perspective, the aim is to promote a broader understanding of sustainability—encompassing both environmental and social dimensions—within building projects. Methodologically, the contribution is twofold. First, it addresses the current gap in context-specific data on the critical indicator of worker health and safety in the construction sector, an essential requirement for robust and scientifically recognised S-LCA studies. To this end, the study develops a regionalised scoring system based on publicly available occupational health and safety data from the Italian National Accident Database (INAIL), disaggregated by sector and region. Second, we propose a framework to combine these social indicators with LCA-based environmental impact metrics, which remain central to building-scale E-LCA. It is clear that no single region performs best, while a critical need for multi-criteria decision-making in sustainable design is evident
The Eastern Coast of the Adriatic in the Journals of Elisabetta Caminer
No full textThis paper covers articles dealing with the eastern coast of the Adriatic, i. e. Venetian
Dalmatia and the Dubrovnik Republic, published in L’Europa Letteraria, Giornale
Enciclopedico, Nuovo Giornale Enciclopedico and Nuovo Giornale Enciclopedico d’Italia,
journals which in the second half of the 18th century were edited by the Venetian writer,
journalist and translator Elisabetta Caminer Turra. Her most important contributor for
writings on this region was Alberto Fortis, author of the famous Viaggio in Dalmazia
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