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L-Acetylcarnitine: a mechanistically distinctive and potentially rapid-acting antidepressant drug.
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Acetyl-L-Carnitine promotes adult hippocampal neurogenesis in vitro via NF-kB mediated upregulation of mGlu2 receptors
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N-Arylbenzamides: extremely simple scaffolds for the development of novel estrogen receptor agonists
No full textThe research of estrogen receptor (ER) ligands has benefited in the last decade from the implementation of combinatorial chemistry. The general pharmacophore has been identified and subsequently a multitude of compounds have been synthesized. Surprisingly, up to now simple amides have not been taken into consideration. Here we show that amides resulting from the condensation of hydroxybenzoic acids with aminophenols result in compounds retaining the pharmacophore structure of an ER ligand with a clear estrogenic activity
A novel mechanism for pergolide-induced neuroprotection: inhibition of NF-kappaB nuclear translocation
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