1,721,003 research outputs found
A cardio-metabolic phenotype in carriers of NPPA (rs5086) and NPPB (rs198389) gene variants in the general population: the dominant role of ANP
No full textAtrial natriuretic peptide: A molecular target of novel therapeutic approaches to cardio-metabolic disease
Full text linkAtrial natriuretic peptide (ANP) is a cardiac hormone with pleiotropic cardiovascular and metabolic properties including vasodilation, natriuresis and suppression of the renin-angiotensin-aldosterone system. Moreover, ANP induces lipolysis, lipid oxidation, adipocyte browning and ameliorates insulin sensitivity. Studies on ANP genetic variants revealed that subjects with higher ANP plasma levels have lower cardio-metabolic risk. In vivo and in humans, augmenting the ANP pathway has been shown to exert cardiovascular therapeutic actions while ameliorating the metabolic profile. MANP is a novel designer ANP-based peptide with greater and more sustained biological actions than ANP in animal models. Recent studies also demonstrated that MANP lowers blood pressure and inhibits aldosterone in hypertensive subjects whereas cardiometabolic properties of MANP are currently tested in an on-going clinical study in hypertension and metabolic syndrome. Evidence from in vitro, in vivo and in human studies support the concept that ANP and related pathway represent an optimal target for a comprehensive approach to cardiometabolic disease
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
MANP: A novel designer natriuretic peptide GC-A activator for the treatment of hypertension and heart failure
No full textHuman arterial hypertension is the most frequent risk factor in the world for cardiovascular disease associated with increased mortality and morbidity. Atrial Natriuretic Peptide (ANP) is a hormone produced by the cardiac atria and has a pivotal role in the regulation of the cardiovascular system and body fluid homeostasis. Its well-known vasomodulatory properties and renin-angiotensin-aldosterone system (RAAS) counteractions, conferred by binding to the Guanylyl Cyclase A Receptor (CG-A) producing the second messenger cyclic GMP) make it a robust therapeutic agent for heart failure and hypertension. Currently, ANP is administered for treatment of HF by continuous intravenous infusion due to short half-life, the main limiting factor for its chronic use. Recently studies have defined a metabolic role of ANP beyond its blood pressure-lowering, natriuretic- and aldosterone-inhibiting properties, such that the ANP gene polymorphism rs5068 is associated with a low cardiovascular risk profile with protection from metabolic syndrome. Further physiological studies established that the gut peptide Glucagon-like Protein 1 (GLP-1) can stimulate the release of ANP from the atria also resulting in cardiorenal protection. Based upon these cardiorenal, humoral and metabolic properties of ANP, we engineered Mutant ANP (MANP) which represents a new and novel ANP-based peptide therapeutic consisting of 40 amino acids where the unique long C-terminus confers to the peptide a greater resistance to degradation than its native form. Indeed, in vitro studies demonstrated fewer sites for degradation and a greater cGMP production than ANP. In vivo studies showed sustained cardiorenal actions with enhanced vasorelaxation not only in normal canines but also in experimental acute hypertension and in hypertensive acute heart failure. In summary, for these reasons, MANP represents a new therapeutic agent for the treatment of chronic and resistant hypertension that is now entering human clinical trials
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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