1,720,955 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The effects of the COVID-19 pandemic on the adolescents' mental health: The role of Intolerance of uncertainty
Get PDFopenL’11 Marzo 2020 la World Health Organization ha dichiarato lo stato di emergenza sanitaria mondiale a causa del COVID-19. La pandemia ha visto convolti tutti i continenti e le persone di varie età. Sono stati presi diversi provvedimenti dalle autorità di ogni paese, tra cui l’obbligo di indossare la mascherina e il lockdown generale; miliardi di persone sono state confinate dentro la propria casa e sono state costrette a non uscire.
Recenti studi stanno dimostrando che questa pandemia, oltre a mietere molte vittime, sta creando numerosi problemi di natura psicologica in adulti e bambini. In particolare, vi è una categoria che si ritiene sia a maggior rischio per la vulnerabilità e per la difficile transizione dovuta all’età, quella degli adolescenti.
In questo elaborato si andrà ad analizzare questa popolazione durante la pandemia da COVID-19, nello specifico verrà analizzato il costrutto di Intolleranza all'Incertezza
Heterogeneity of predictive biomarkers in gastric cancer with peritoneal dissemination
No full textreservedBackground. Gastric cancer (GC) is the fifth most common malignancy and the fourth leading cause of cancer-related death worldwide.
Peritoneal dissemination has been described in 10-20% of all patients, and despite diagnostic and therapeutic advances it is still associated with a poor prognosis, with a median survival time of 4 months.
Aim of the study. Temporal and spatial molecular heterogeneity is a well-established mechanism of resistance to targeted and immune therapy in GC, and while systemic treatments primarily address the metastatic disease, biomarker status is currently evaluated in the primary tumor.
The aim of this study is to assess the differences in predictive biomarkers expression between primary GCs and paired peritoneal metastases.
Materials and methods. A total of 82 cases of primary GCs and paired peritoneal metastases were analyzed by immunohistochemistry for HER2, PD-L1, Claudin18.2 (CLDN18.2), DNA mismatch repair complex (MMR) proteins, p53 and E-cadherin, and in situ hybridization for EBER.
Samples with HER2 score 2+ were tested by fluorescent in situ hybridization for HER2 gene status.
Results. The primary GCs of our cohort were more frequently poorly cohesive (49.4%) or mixed-type (35.4%); they showed low rates of HER2 overexpression (5.1%), MMR deficiency (3.8%), and EBER positivity (1.3%).
CLDN18.2 was positive in 30.4% of cases, and PD-L1 was CPS≥1 in 78.5%.
The highest discordance rate between primary GCs and paired metastases was observed for PD-L1 CPS<1/1≤CPS<10/CPS≥10 (32.4%) and CLDN18.2 (13.5%).
A relatively low discordance was reported for HER2 (2.7%), E-cadherin (5.4%), and p53 (1.4%). When scoring HER2 as 0/low/high, the discordance rate increased (27.0%).
All cases were concordant for MMR and EBER status.
Overall, up to 20/74 patients (27.0%) were found to be eligible for further treatment following biomarker evaluation in the metastasis.
Conclusions. Our data suggests that GCs with peritoneal metastases have specific morphologic features and might present clinically-relevant spatial molecular heterogeneity in the setting of peritoneal dissemination.
With the introduction of novel biomarkers (i.e., HER2-low and CLDN18.2) in clinical practice, the need to address heterogeneity between primary tumors and metastases is becoming more pressing.
Multisite sampling, liquid biopsy and cell blocks prepared from malignant effusions should be explored to more accurately identify patients eligible for targeted therapy, and to overcome spatial heterogeneity fueling resistance to treatments.Background. Gastric cancer (GC) is the fifth most common malignancy and the fourth leading cause of cancer-related death worldwide.
Peritoneal dissemination has been described in 10-20% of all patients, and despite diagnostic and therapeutic advances it is still associated with a poor prognosis, with a median survival time of 4 months.
Aim of the study. Temporal and spatial molecular heterogeneity is a well-established mechanism of resistance to targeted and immune therapy in GC, and while systemic treatments primarily address the metastatic disease, biomarker status is currently evaluated in the primary tumor.
The aim of this study is to assess the differences in predictive biomarkers expression between primary GCs and paired peritoneal metastases.
Materials and methods. A total of 82 cases of primary GCs and paired peritoneal metastases were analyzed by immunohistochemistry for HER2, PD-L1, Claudin18.2 (CLDN18.2), DNA mismatch repair complex (MMR) proteins, p53 and E-cadherin, and in situ hybridization for EBER.
Samples with HER2 score 2+ were tested by fluorescent in situ hybridization for HER2 gene status.
Results. The primary GCs of our cohort were more frequently poorly cohesive (49.4%) or mixed-type (35.4%); they showed low rates of HER2 overexpression (5.1%), MMR deficiency (3.8%), and EBER positivity (1.3%).
CLDN18.2 was positive in 30.4% of cases, and PD-L1 was CPS≥1 in 78.5%.
The highest discordance rate between primary GCs and paired metastases was observed for PD-L1 CPS<1/1≤CPS<10/CPS≥10 (32.4%) and CLDN18.2 (13.5%).
A relatively low discordance was reported for HER2 (2.7%), E-cadherin (5.4%), and p53 (1.4%). When scoring HER2 as 0/low/high, the discordance rate increased (27.0%).
All cases were concordant for MMR and EBER status.
Overall, up to 20/74 patients (27.0%) were found to be eligible for further treatment following biomarker evaluation in the metastasis.
Conclusions. Our data suggests that GCs with peritoneal metastases have specific morphologic features and might present clinically-relevant spatial molecular heterogeneity in the setting of peritoneal dissemination.
With the introduction of novel biomarkers (i.e., HER2-low and CLDN18.2) in clinical practice, the need to address heterogeneity between primary tumors and metastases is becoming more pressing.
Multisite sampling, liquid biopsy and cell blocks prepared from malignant effusions should be explored to more accurately identify patients eligible for targeted therapy, and to overcome spatial heterogeneity fueling resistance to treatments
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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