20 research outputs found
Key issues in tracheal injuries and complications
No full textANNALS OF CLINICAL AND ANALYTICAL MEDICINEAim: In this study, we aimed to investigate the histopathological changes in tracheal epithelia after conventional tracheostomy in a rabbit model. Material and Methods: Thirty-nine male New Zealand White rabbits were used for this study. They were randomly divided into five groups. Classic tracheostomy was carried out in 29 subjects. Group 1, which was created after any surgical procedure, served as a control group. After tracheostomy, we applied sterile saline in Group 2, Mitomycin-C (MMC) (0.8 mg/ml) in Group 3, MMC (0.4 mg/ml) in Group 4 and 5-Fluorouracil (5-FU) (10 mg/ml) in Group 5 around tracheotomy for 5 minutes. Results: At three weeks after surgery, tracheas were evaluated by morphometric and histopathological examination, including tracheal lumen diameter, the number of capillary vessels, subepithelial tissue thickness, fibroblasts, and inflammatory cells. There were statistically significant differences between tracheostomy and control group for tracheal lumen diameter (P0.35), number of capillary vessels (P0.06), subepithelial tissue thickness, fibroblasts and number of lymphocyte (p < 0.001). Histopathological analysis showed decreased fibrosis in both of the groups treated with MMC and 5-FU. Discussion We believed that wound healing modulation may prevent scar formation, but requires further treatment. Herein, as we have shown in our study, fibroblasts are critical cells, but not one. MMC and 5-FU are medications that have been used for antiproliferative activity on fibroblasts
Prognostic factors in mechanically ventilated patients
No full textAim: In this study, we aimed to investigate the prognostic values of respiratory parameters recorded within the first 48 hours in patients connected to mechanical ventilation in the intensive care unit (ICU), in terms of 30-day mortality. Material and Method: This prospective study included patients who received mechanical ventilation due to acute respiratory failure between 2011 and 2013. The demographic characteristics of the patients, Glasgow Coma Score (GCS) scores, Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) values, vital signs, the results of complete blood count, biochemistry parameters and blood gas analyses were recorded. Patients were divided into two groups as survivors and non-survivors, and the differences in the parameters between the groups were analysed. Results: The study included 99 mechanically ventilated patients with the mean age 71.73 (18-105) years. Of the patients, 56 (56.6%) were male and 43 (43.4%) were female. Comparison of the survivors (n=37) with the non-survivors (n=62) indicated that the non-survivors had no statistical differences in terms of age, gender, or concomitant diseases. The values of GCS, APACHE II, and SOFA were significantly different between survivors and non-survivors (for all, p<0.001). Significant differences were also noted in FiO2 (p<0.001), pH (p=0.001), PO2 (p=0.044), PCO2 (p=0.046), A-a Gradient (p<0.001) and the expected increase of O2 gradient (p=0.026) between two groups. Discussion: Our findings indicate that, during the follow-up of the mechanically ventilated patients, respiratory parameters measured within the first 48 hours are cheap and easy-to-use parameters to predict the prognosis
Rib fractures: Could we accelerate the healing?
No full textAim: We thought about How fractures are improving more rapidly. For this purpose, we made an experimental model to investigate the effect of zinc supplementation on the development of new bone in young rabbits. Material and Method: Six weeks of age, male New Zealand white rabbits were evaluated in four groups, each including five subjects. To simulate the RFs, subperichondrial costal cartilage resections beginning from the third costal cartilage were carried out in the right hemithorax according to groups. Rabbits in Group 1 and 2 underwent partial resection of the two ribs; rabbits in Group 3 and 4 underwent total resection of those. Zinc was administered by intraperitoneal injection of 6 mg/kg/ day for four weeks after the surgery for group 2 and 4. The animals were followed-up at the twenty-fourth week of their life. Results: We analyzed histologic changes in the bone. There were statistically significant differences for osteoblasts and osteoclasts among all subgroups. Histologic consolidation was significantly increased by zinc supplementation. According to the literature, in our study, while zinc stimulates osteoblastic bone formation, suppresses osteoclastic bone resorption. Discussion: Although the proper treatment of rib fracture (RF), long-term disability and persistent chest wall pain frequently develop and may take several months to recover, leads to the high hospital, medicine, labor, and social burden. Our findings indicate that zinc supplementation accelerates the consolidation of ribs. Zinc can be used to increase the bone maturation such as the site of new bone formation in RF.School of Medicine Animal CareThis study was approved and funded by the School of Medicine Animal Care and Investi-gational Committee in our institution
The Effects of Low Dose Zinc Supplementation on the Development of New Bone in Rabbits
Get PDFIntroduction: Zinc (Zn) is an essential element for the healthy bone metabolism. It promotes bone formation by stimulating the proliferation and differentiation of osteoblasts, and increases the stimulation of osteoblastic bone mineralisation. Also, it suppresses the differentiation of osteoclasts while inhibiting bone resorption. The purpose of this study is to investigate the effects of low-dose Zn supplementation on new bones grown in rabbits. Methods: We evaluated 40 male white rabbits aged six weeks from New Zealand in 8 groups, with each including 5 subjects. All the groups underwent subperichondrial costal cartilage resections from the third rib on the right hemithorax. Rabbits in first and second groups underwent the partial resection of two ribs, and rabbits in third and fourth groups underwent total rib resection. Rabbits in fifth and sixth groups underwent the partial resection of four ribs, whereas rabbits in seventh and eighth groups underwent total resection. Rabbits in Groups 2, 4, 6, and 8 were treated with 6 mg/kg/day intraperitoneal Zn for four weeks after the operation. All groups were followed up to the 24th week of their lives. Results: We detected a statistically significant difference for both osteoblasts and osteoclasts among all the subgroups. Additionally, we also detected a significant increase in bone consolidation by Zn supplementation. Our study found that Zn suppresses osteoblastic bone absorption by stimulating osteoblastic bone formation in the light of the literature. Conclusion: Low-dose Zn administration in rabbits has been found to expedite the rib consolidation. Zn can be used to increase the bone maturation such as at the site of new bone formation in rib fracture and after all kinds of operations related to bones.School of Medicine Animal CareThis study was approved and funded by the School of Medicine Animal Care and Investigational Committee at our institution. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript
The effect of costal cartilage resection on the chest wall development: Pathological evaluation
No full text[Abstract Not Availabe
How successful is pleural sound sign in the identification of pneumothorax?
Get PDFOBJECTIVE: In the present study, in thorax ultrasonography (USG) Doppler images obtained from cases with occult pneumothorax, we investigated the status of pulsatile pleural sounds over the pleural line and called these as the pleural sound sign (PSS). The purpose of the present study was to identify the efficacy of the proposed PSS in diagnosing pneumothorax and to compare it with the other USG findings including the sliding lung sign (SLS) and seashore sign (SSS). METHODS: The present study included 66 consecutive patients who were referred to the emergency unit with a blunt trauma from October 2009 to January 2010 at a tertiary university hospital. RESULTS: Of the 66 patients, 34 were in the patient group, and 32 were in the control group. Males accounted for 66.7% (n=44) of the study population. In predicting pneumothorax, the areas under receiver operating characteristic (ROC) curves of PSSmax and PSSdifference were 0.989 and 0.990, respectively. While the sensitivity of the SLS was 88% and the sensitivity of the SSS was 56%, the specificities of the SLS and SSS were 100%. Based on our findings, accuracy ranking was as follows: PSSmax = PSSdifference > SLS > SSS. CONCLUSION: New applications of thorax USG are rapidly growing. Our findings have to be confirmed in a large patient series. PSS is not a novel method, but it enhanced the importance of USG in the diagnosis of pneumothorax. We can stipulate that it can replace thorax computed tomography imaging particularly for the diagnosis of occult pneumothoraxes
