1,721,015 research outputs found
Apoptotic effects of acacetin in human colon cancer HT-29 and HCT 116 cells
No full textAim: Acacetin is a natural flavone compound, which is found in several plants as Robinia pseudoacacia and is demonstrated to have anticancerogenic activities in many types of cancer (e.g., human nonsmall cell lung cancer, and prostate). Colorectal carcinoma (CRC) is one of the serious health problems and is a complex disease. We intended to find a more effective new candidate for the treatment of colon cancer, and hence, we designed this study to investigate the effects of acacetin on CRC (HT-29, HCT 116) in vitro. Methods: The study was carried out with the methods that determine for apoptosis (WST-1, Caspase 3/BCA, Annexin V). Results: Acacetin showed antitumor and apoptosis-inducing effects in the CRC cell lines. Conclusions: Acacetin was effective on CRC cell lines, besides no lethal effect on healthy lung cells (MRC-5)
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Covid-19: Molecular and Clinical Approach / Covid-19: Moleküler ve Klinik Yaklaşım
No full textPublishedKoronavirüs ailesinden olan şiddetli akut solunum sendromu koronavirüs 2 (SARS-CoV-2), 2019 Aralık ayının sonunda Çin’in Wuhan kentinden başlayarak hızla tüm dünyaya yayılmıştır. Dünya Sağlık Örgütü tarafından “küresel salgın” olarak ilan edilen ve kaynağı henüz netlik kazanmamış olan virüsün en önemli özelliği hızlı bir şekilde damlacık yoluyla yayılmasıdır. Bu özelliği sayesinde kısa süre içerisinde geniş kitleleri etkilemiş ve dünyanın birçok ülkesinde binlerce ölüme neden olmuş, olmaya da devam etmektedir.
Koronavirüsler insanları ve çeşitli hayvan türlerini enfekte edebilen RNA virüsleridir. Koronavirüslerin alfa, beta, gamma ve delta olmak üzere dört farklı cinsi vardır. Alfa ve beta koronavirüs insanları enfekte edebilirken, gamma ve delta koronavirüs sadece hayvanları enfekte edebilmektedir. COVID-19 hastalığına sebep olan “SARS-CoV-2” adlı yeni tip koronavirüs canlıların vücuduna göz, burun veya ağız yoluyla girmekte ve organizmaya giren virüs akciğer gibi solunum yolunda bulunan “ACE2 reseptörü” aracılığıyla hücrelere yapışmaya çalışmaktadır. SARS-CoV-2’nin neden olduğu hastalık Koronavirüs hastalığı-19 (COVID-19) olarak adlandırılmıştır. COVID-19 ismi “CO” ve “VI” koronovirüsten, “D” ingilizcede hastalık anlamına gelen “disease” kelimesinden, 19 ise vakaların görülemeye başlandığı 2019 yılından gelmektedir.
Bu kitapta COVID-19 hastalığının farklı boyutları çok değerli öğretim üyelerimiz tarafından kaleme alınmıştır. Tüm yazarlarımıza, bu zor ve stresli dönemde verdikleri katkılarından dolayı teşekkür ediyor, kitabımızı COVID-19 ile savaşırken kaybettiğimiz tüm sağlık çalışanlarına adıyoruz
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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