8,893 research outputs found
Opportunities and challenges of Blockchain-Oriented systems in the tourism industry
No full textThe tourism industry is increasingly influenced by the evolution of information and communication technologies (ICT), which are revolutionizing the way people travel. In this work we want to investigate the use of innovative IT technologies by DMOs (Destination Management Organizations), focusing on blockchain technology, both from the point of view of research in the field, and in the study of the most relevant software projects. In particular, we intend to verify the benefits offered by these IT tools in the management and monitoring of a destination, without forgetting the implications for the other stakeholders involved. These technologies, in fact, can offer a wide range of services that can be useful throughout the life cycle of the destination
Precision medicine and nucleotide-based therapeutics to treat steatotic liver disease
No full textMetabolic dysfunction-associated steatotic liver disease (MASLD) is a complex multifactorial disease and becoming the leading cause of liver-related morbidity and mortality. MASLD spans from isolated steatosis to metabolic dysfunction-associated steatohepatitis (MASH), that may progress to cirrhosis and hepatocellular carcinoma (HCC). Genetic, metabolic, and environmental factors strongly contribute to the heterogeneity of MASLD. Lifestyle intervention and weight loss represent a viable treatment for MASLD. Moreover, Resmetirom, a thyroid hormone beta receptor agonist, has recently been approved for MASLD treatment. However, most individuals treated did not respond to this therapeutic suggesting the need for a more tailored approach to treat MASLD. Oligonucleotide-based therapies, namely small-interfering RNA (siRNA) and antisense oligonucleotide (ASO), have been recently developed to tackle MASLD by reducing the expression of genes influencing MASH progression, such as PNPLA3 and HSD17B13. Here, we review the latest progress made in the synthesis and development of oligonucleotide-based agents targeting genetic determinants of MASH
Cation-site Disordered Cu3PdN Nanoparticles for Hydrogen Evolution Electrocatalysis
No full textThis datasets contains data which is presented in the manuscript with the title "Cation-site Disordered Cu3PdN Nanoparticles for Hydrogen Evolution Electrocatalysis" by Sani Y. Harouna-Mayer, Jagadesh Kopula Kesavan, Francesco Caddeo, Lian Belgardt, Chia-Shuo Hsu, Lars Klemeyer, Lizzi Kipping, Melike Gumus Akcaalan, Tjark R.L. Groene, Andrea Koeppen, Hechmat Noei, Olivier Mathon, Ann-Christin Dippel and Dorota Koziej. (https://doi.org/10.1002/smll.202506838) The processing of the data is described in detail in the supporting information of the manuscript
TM6SF2 and PNPLA3: A potential dynamic duo?: Editorial on “TM6SF2 E167K variant decreases PNPLA3-mediated PUFA transfer to promote hepatic steatosis and injury in MASLD”
No full textAndrea Bacová
No full textAndrea Bacová focuses on research and teaching in the field of residential architecture. Her work includes systematic research on residential buildings and their urban context. She actively participates in promoting Slovak architecture and is the author of several publications and exhibitions
SO(2)- invariant minimal and constant mean curvature surfaces in 3-dimensional homogeneous spaces
No full textWe study SO(2)-invariant minimal and constant mean curvature surfaces in R^3 endowed with a homogeneous Riemannian metric whose group of isometries has dimension greater or Equal to 4
Viewer-, Author-, and Ownership in the Work of Andrea Zittel
No full textAndrea Zittel invites others to collapse the distinctions between artist, viewer, and collaborator by interacting with her usable works. This thesis explores the process of interacting with Zittel\u27s works, and how it affects viewer-, author- and ownership
Novel thyroid hormone receptor-beta agonist TG68 safely induces hepatic fat reduction in a non-alcoholic steatohepatitis rat model
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