1,720,959 research outputs found
EXPRESSION AND ACTIVITY OF GPR17, A NEW NUCLEOTIDE-CYSTEINYL-LEUKOTRIENE RECEPTOR, IN NEURONAL PC12 CELL MODEL.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A2A-D2 Receptor Heterodimerization and Psychosis
No full textNeuroleptic drugs, classified in typical and atypical, mainly act as D2 dopamine receptor antagonists. D2 and A2A receptors are co-expressed in the striatum where they structurally interact to form functional heterodimers. It has been demonstrated these receptors show a positive or negative functional cross-talk in dependence on their relative expression levels. To clarify the reciprocal interactions between adenosine and dopaminergic system in physiological conditions, we investigated the regulation of A2A adenosine receptor induced by D2 receptor antagonists in PC12 cells co-expressing both receptors in native conditions and in CHO cells co-expressing both receptors at levels comparable to those reported in striatum. In PC12 we were able to detect both receptors in the monomeric and dimeric form. Moreover, after chronic treatment with the typical antipsychotic haloperidol our results showed an increase of affinity and density of A2A receptor compared with the control, while treatment with atypical antipsychotics risperidone and clozapine did not show any significant difference. Treatment with haloperidol and risperidone showed an uncoupling of A2A receptor to G proteins and a significant decrease of cAMP levels. Chronic treatment with clozapine did not show any difference also in the G protein coupling and cAMP levels. In CHO cells our data showed that acute and chronic treatment with haloperidol increased the A2A AR affinity and responsiveness whereas no effects were detected with the atypical drug, clozapine. Otherwise, risperidone, an atypical antipsychotic but with high affinity for D2 DR, after long treatment induced a significant decrease of A2A AR affinity and responsiveness. Our results ascertain that A2A receptors are modulated by typical antipsychotics and by risperidone which profile does not fully fit to the atypical antipsychotic profile and these effects depend on the receptor levels. Our data suggest adenosine system as an alternative target for pathologies characterized by dopamine system dysfunction. In the same way, since A2A receptors are involved in brain damage, individual control of antipsychotic therapy and the associated regulation of adenosine system, may represent an important goal to control neurodegenerative processes considered as an amplificatory loop in several psychiatric disorders
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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