2,498 research outputs found
Elastic-DF: Scaling Performance of DNN Inference in FPGA Clouds through Automatic Partitioning
No full textCustomized compute acceleration in the datacenter is key to the wider roll-out of applications based on deep neural network (DNN) inference. In this article, we investigate how to maximize the performance and scalability of field-programmable gate array (FPGA)-based pipeline dataflow DNN inference accelerators (DFAs) automatically on computing infrastructures consisting of multi-die, network-connected FPGAs. We present Elastic-DF, a novel resource partitioning tool and associated FPGA runtime infrastructure that integrates with the DNN compiler FINN. Elastic-DF allocates FPGA resources to DNN layers and layers to individual FPGA dies to maximize the total performance of the multi-FPGA system. In the resulting Elastic-DF mapping, the accelerator may be instantiated multiple times, and each instance may be segmented across multiple FPGAs transparently, whereby the segments communicate peer-to-peer through 100 Gbps Ethernet FPGA infrastructure, without host involvement. When applied to ResNet-50, Elastic-DF provides a 44% latency decrease on Alveo U280. For MobileNetV1 on Alveo U200 and U280, Elastic-DF enables a 78% throughput increase, eliminating the performance difference between these cards and the larger Alveo U250. Elastic-DF also increases operating frequency in all our experiments, on average by over 20%. Elastic-DF therefore increases performance portability between different sizes of FPGA and increases the critical throughput per cost metric of datacenter inference. Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Computer Engineerin
Hydrodynamical turbulence by fractal fourier decimation
No full textWe present a systematic numerical investigation of high-resolution 3D isotropic and homogeneous turbulence resolved on a decimated set of Fourier modes. Fractal decimation acts to decrease the effective dimensionality of the flow by allowing triadic interactions only in a set of Fourier modes N(k) proportional to k^DF for large k. While keeping the symmetries of the original 3D Navier-Stokes equations unchanged, a dramatic change in small-scale statistics is detected at decreasing the fractal dimension DF . Already at fractal dimension DF = 2.8, a global self-similar behaviour is observed in the inertial range of scales, the consequence of such transition are the restoration of the scaling symmetry and vorticity distribution that becomes close to Gaussian. We relate the results to the different roles of local vs non-local interactions in the energy transfer range
'Response by the author, Daniel F. Vukovich.'
No full textResponse by the author (Vukovich) to a review of Illiberal China (my 2019 monograph
DF AND HF LASER SPECTRA
No full textW. B. Roh and K. Narahari Rao, J. Mol. Spectrosc. 49, 317 (1974).""Author Institution: Department of Physics, The Ohio State University; Department of Electrical Engineering, The Ohio State UniversityA pulsed laser was used as a source to study DF and HF infrared laser spectra with a grating spectrometer. The rotational structure observed for the 1-0, 2-1, and 3-2 bands of DF, and the 1-0 and 2-1 bands of HF has been measured by following a procedure similar to that used for the CO laser Molecular constants derived by combining these laser measurements with other available data will be presented
OPTOACOUSTIC MEASUREMENT OF DF LASER ABSORPTION BY METHANE
No full textAuthor Institution:An optoacoustic system has been constructed for measurement of absorption of DF laser radiation. Absorption by methane in Argon and Nitrogen has been measured at 15 DF laser lines in the 3.6 – 4.0 region. Construction and calibration of the spectrophone will be discussed
Serotonin receptor mechanisms in anti-depressant action
No full textBibliography: leaves 221-270.Serotonin neurones have been implicated in the pathophysiology and treatment of clinical depression to a greater degree than any other neurotransmitter. Additionally, serotonin pathways may playa role in the pathophysiology and treatment of eating disorders, anxiety states and schizophrenia. Molecular biological studies have confirmed pharmacological evidence suggesting the existence of multiple serotonin receptor subtypes and the genes for these receptors, as well as that of the serotonin transporter, have common polymorphic variants. To investigate the effect of repeated treatment with selective serotonin fe-uptake inhibitors (SSRI's) on the function of central 5-HT2C receptors. To assess the effect of polymorphic variation in the 5-HT2c receptor and serotonin transporter on functional responses to selective pharmacological challenge. To determine whether polymorphic variation in the 5-HT receptor and serotonin transporter influence the clinical response of patients with major depression to treatment with serotonergic antidepressants. To assess the effect of repeated treatment with selective serotonin re-uptake inhibitors (SSRI's) on the function of central 5-HT2c receptors I used the 5-HT2C receptor agonist, m-chlorophenylpiperazine (m-CPP) as a 5-HT2c probe in a neuroendocrine challenge paradigm. I used the same approach to assess whether polymorphic variation in the 5-HT2c receptor (serine vs cysteine substitution) was associated with differences in functional response to 5-HT2C receptor challenge. I then studied whether polymorphic variation in the serotonin transporter promotor region (long versus short form) was associated with differing functional responses to acute challenge with clomipramine, a tricyclic antidepressant with a high affinity for the serotonin transporter. Finally, I studied whether either of these polymorphic variants influenced the clinical response of patients with major depression to treatment with SSRI's and clomipramine. SSRI treatment significantly lowered the sensitivity of 5-HT2c receptors as predicted from animal experimental studies. However polymorphic variation in the 5-HTzc receptor did not significantly influence functional responses to m-CPP challenge. In contrast polymorphic variation in the serotonin transporter was associated with differing neuroendocrine responses to acute clomipramine challenge with greater prolactin release being seen in subjects with the long polymorphic variant. Neither the 5-HTzc nor the transporter polymorphisms correlated with clinical response to SSRI and clomipramine treatment in patients with major depression. The ability of SSRI's to produce a functional down-regulation of 5-HTzc receptors may be relevant to certain of their therapeutic effects. Polymorphic variation in the 5-HT2c receptor (serine vs cysteine) seems unlikely to explain functional differences in responses to 5-HTzc receptor challenge or antidepressant responses to SSRI treatment. In contrast variation in the serotonin transporter promotor is associated with differing functional responses to acute serotonin re-uptake blockade. However, this did not correlate with clinical response to longer-term SSRI treatment
Comparison of system architecture and converter topology for a solar powered electric vehicle charging station
No full textAccepted Author ManuscriptOld - EWI-ESE-DC&S DC systems & StoragePhotovoltaic Materials and Device
Simulation of a surface-transverse wave (STW) biosensor for DF-1 cells
No full textA 250 MHz Surface-Transverse Wave (STW) resonator is employed as a sensor element for the
detection of DF-1 cells. STW belongs to the shear-horizontal acoustic plate modes (SH-APM) waves’
family where it has attracted plenty considerable interest. STWs are horizontally polarized shear waves
which are generated and detected by the interdigital transducers (IDTs) similar to surface-acoustic wave
(SAW) resonators [1]. Detection of chemical and biological agents in aqueous solutions is a difficult
problem, especially when the detection technique has to be sensitive, power-efficient and very handy.
Acoustic plate mode is a mode of vibration where particle motion is parallel to the surface. This makes it
possible to produce a sensitive sensor capable of operating in fluids [2]. This paper presents the biosensor
prototype utilizing STW resonator
Period changes of two contact binaries: DF Hya and WZ And
No full text33rd International Physics Congress of the Turkish-Physical-Society (TPS) -- SEP 06-10, 2017 -- Bodrum, TURKEYOrbital period variations of two contact binaries DF Hya and WZ And are analyzed with the least-squares method by using all available minima times. It is shown that the period variations of these systems are due mainly to the LightTime Effect (LITE) due originates from gravitational influence of a third body. New LITE elements such as, orbital periods and minimum masses of possibility third bodies are given.Turkish Phys So
Delivery of bioactive molecules to the mitochondrial genome using a membrane-fusing, liposome-based carrier, DF-MITO-Porter.
No full textMitochondrial dysfunction has been implicated in a variety of human diseases. It is now well accepted that mutations and defects in the mitochondrial genome form the basis of these diseases. Therefore, mitochondrial gene therapy and diagnosis would be expected to have great medical benefits. To achieve such a strategy, it will be necessary to deliver therapeutic agents into mitochondria in living cells. We report here on an approach to accomplish this via the use of a Dual Function (DF)-MITO-Porter, aimed at the mitochondrial genome, so-called mitochondrial DNA (mtDNA). The DF-MITO-Porter, a nano carrier for mitochondrial delivery, has the ability to penetrate the endosomal and mitochondrial membranes via step-wise membrane fusion. We first constructed a DF-MITO-Porter encapsulating DNase I protein as a bioactive cargo. It was expected that mtDNA would be digested, when the DNase I was delivered to the mitochondria. We observed the intracellular trafficking of the carriers, and then measured mitochondrial activity and mtDNA-levels after the delivery of DNase I by the DF-MITO-Porter. The findings confirm that the DF-MITO-Porter effectively delivered the DNase I into the mitochondria, and provides a demonstration of its potential use in therapies that are selective for the mitochondrial genome
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