1,721,362 research outputs found

    Coppola¨s Path to "the godfather"

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    The graduation theses ?Coppola?s approach to the Godfather? deals with the situation before the actual production of the film, tells us about conditions the film studio Paramount was in and about the difficult pre-production process, that in many aspects influenced the final feature presentation. There is also an analysis of Michael Corleone?s story and motives, that controverts with the myths and reality of American Mafia

    GSH extrusion and and the mitochondrial pathway of apoptotic signalling

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    New evidence suggests that physiological and damaging agents activate two different pathways of apoptotic signalling, which are mediated by protein-protein interactions and mitochondrial alterations respectively. The two pathways converge at the activation of caspase 3, the key effector of the execution phase of apoptosis, thus giving similar final results. The knowledge that different biochemical routes exist allows us to re-evaluate previous apparently contradictory results concerning the events occurring during apoptosis, and their respective roles. In particular, this applies to the role of oxidative stress and redox imbalance in the signal transduction events of apoptosis. It now appears that oxidative alterations are absent, or at least unnecessary, for the development of the physiological pathway. Instead, clear indications are emerging showing that redox imbalance is required for the damage-induced mitochondrial pathway. This is suggested by the finding that the depletion of glutathione, a common event in damage-induced apoptosis, is necessary and sufficient to induce cytochrome c release, the key event of this pathway. A model is proposed with GSH efflux as the backbone of the damage-induced apoptotic pathway

    La gestione dell'insuccesso medico. Nuove strategie per contenere la litigiosità nelle strutture sanitarie

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    La dignità del paziente e il rispetto della sua autonomia e partecipazione sono valori sottostanti il tema (e il problema) del consenso informato. Si tratta di valori che meritano considerazione nello svolgimento di tutto l’arco del trattamento sanitario. Nel caso d’insuccesso del trattamento, per qualunque causa verificatosi, si aprono complessi problemi di carattere psicologico e umano e questioni di rilievo civilistico (risarcimento del danno, intervento assicurativo, ricorso al giudice, ecc.) ed anche penale. L’insuccesso inoltre pone la questione dell’identificazione degli interventi che sia utile effettuare per rimuovere le cause (ad esempio organizzative), che l’hanno causato o non impedito

    Rocca Colonna a Castelnuovo di Porto: un presidio fortificato nel paesaggio della valle tiberina

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    The center on Tiber valley have a landscape dimension that today represents a particular element into the characterization and perception of historical urban contexts. This area owns a specific morphology made by tuffaceous rocks and the typical landscape of alluvial plains, marked by Tiber’s river. Castelnuovo di Porto is a small village in the north of Rome situated in Veio Park, that preserves, even today, its original urban structure. The paper aims to highlight how the enhancement and re-use of the Rocca, inside the brought, must be evaluated in line with the landscape in the overall meaning by proposing, from one side, the protection and conservation of some naturalistic aspects such as the wide band of respect (between the Via Flaminia, the church of San Sebastiano and Valle Linda), panoramic frame and green lung of the village, and on the other, design hypotheses that integrate built and natural landscape
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