1,721,373 research outputs found
Additional file 1 of Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort
No full textAdditional file 1. Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort
The CONSTANCES cohort: an open epidemiological laboratory
No full textAbstract Background Prospective cohorts represent an essential design for epidemiological studies and allow for the study of the combined effects of lifestyle, environment, genetic predisposition, and other risk factors on a large variety of disease endpoints. The CONSTANCES cohort is intended to provide public health information and to serve as an "open epidemiologic laboratory" accessible to the epidemiologic research community. Although designed as a "general-purpose" cohort with very broad coverage, it will particularly focus on occupational and social determinants of health, and on aging. Methods/Design The CONSTANCES cohort is designed as a randomly selected representative sample of French adults aged 18-69 years at inception; 200,000 subjects will be included over a five-year period. At inclusion, the selected subjects will be invited to fill a questionnaire and to attend a Health Screening Center (HSC) for a comprehensive health examination: weight, height, blood pressure, electrocardiogram, vision, auditory, spirometry, and biological parameters; for those aged 45 years and older, a specific work-up of functional, physical, and cognitive capacities will be performed. A biobank will be set up. The follow-up includes a yearly self-administered questionnaire, and a periodic visit to an HSC. Social and work-related events and health data will be collected from the French national retirement, health and death databases. The data that will be collected include social and demographic characteristics, socioeconomic status, life events, behaviors, and occupational factors. The health data will cover a wide spectrum: self-reported health scales, reported prevalent and incident diseases, long-term chronic diseases and hospitalizations, sick-leaves, handicaps, limitations, disabilities and injuries, healthcare utilization and services provided, and causes of death. To take into account non-participation at inclusion and attrition throughout the longitudinal follow-up, a cohort of non-participants will be set up and followed through the same national databases as participants. A field-pilot was performed in 2010 in seven HSCs, which included about 3,500 subjects; it showed a satisfactory structure of the sample and a good validity of the collected data. Discussion The constitution of the full eligible sample is planned during the last trimester of 2010, and the cohort will be launched at the beginning of 2011.</p
Main characteristics of the study participants recruited in the French CONSTANCES cohort between 2012 and 2015, by gender (N = 59 805).
No full textMain characteristics of the study participants recruited in the French CONSTANCES cohort between 2012 and 2015, by gender (N = 59 805).</p
Characteristics of the 18,879 included participants from the CONSTANCES cohort and according to their employment status at one-year follow-up.
No full textCharacteristics of the 18,879 included participants from the CONSTANCES cohort and according to their employment status at one-year follow-up.</p
Risk of job loss at one-year according to substance use, adjusting for age, gender, self-reported health and depressive symptoms, among 18,879 participants from the CONSTANCES cohort.
No full textRisk of job loss at one-year according to substance use, adjusting for age, gender, self-reported health and depressive symptoms, among 18,879 participants from the CONSTANCES cohort.</p
Consequences of asthma on occupational and socio-economic characteristics in the Constances cohort
No full textInternational audienceContext: Prior studies have shown that people suffering from occupational asthma may experience severe socioeconomic consequences. Analyses of the French national SIP (Santé et Itinéraire Professionnel) survey data suggested that women with asthma had more complex career paths and lower incomes compared to women without asthma. The objective of the present study is to examine the link between asthma and employment and socioeconomic status in the Constances cohort in France.Methods: This study was based on data collected at inclusion by self-administered questionnaire from the 34 085 people aged between 18 to 69 years included in 2013 and 2014 in the Constances cohort. Current asthma was defined by the participants either having asthma attack or use of asthma medication in the 12 months before interview. The socio-occupational parameters studied were the following: employment status, monthly household income, social category and economic sector of activity, and the number and duration of job periods and those of interruptions in the job history. Comparisons between people with asthma and those without asthma were made, separately in men and women.Results: The current asthma prevalence was 6,0%. Women with asthma had a higher number of job periods compared to those without asthma (34% and 27% respectively had more than 4 job periods). Among men, no difference according to asthma status was observed for the number and duration of job or interruption periods.Conclusion: These first results suggest that women with asthma experience more instable career path than women without asthma. In contrast, no such results were observed in men. Further analyses are still being carried out
MSC914323 Supplementary material - Supplemental material for Patterns of gynaecological check-up and their association with body mass index within the CONSTANCES cohort
No full textSupplemental material, MSC914323 Supplementary material for Patterns of gynaecological check-up and their association with body mass index within the CONSTANCES cohort by Jeanna-eve Franck, Virginie Ringa, Laurent Rigal, Jeanne Sassenou, Mireille Cœuret-Pellicer, Pierre Chauvin and Gwenn Menvielle in Journal of Medical Screening</p
Proportion of At-Risk Alcohol Consumers According to the New French Guidelines: Cross-Sectional Weighted Analyses From the CONSTANCES Cohort
Get PDFObjective: To estimate the proportion of the participants of the French national population-based CONSTANCES cohort exceeding the new low-risk drinking guidelines according to sociodemographic and clinical factors.Methods: From 34,470 participants with follow-up data in 2019, among volunteers aged 18–69 years and invited to enroll in the CONSTANCES cohort in 2016 and 2017, weighted prevalence and odds ratios with 95% confidence intervals (CI) exceeding the guidelines using logistic regressions were presented stratified for age, gender, education, occupational grade, employment, income, marital status, pregnancy, work stress, depression, alcohol dependence, binge drinking, cannabis use, smoking status, e-cigarette use, cardiovascular diseases, and cancer.Results: The guidelines were exceeded more by men at 60.2% (95%CI: 59.3%–61.0%) than by women at 36.6% (95%CI: 35.9%–37.4%). Exceeding the guidelines increased with age, socioeconomic status, smoking, vaping, using cannabis, binge drinking, and alcohol dependence. Being depressed was associated with exceeding the guidelines in women. Even though pregnant women were less likely to exceed the guidelines, 7.6% (95%CI: 5.4%–10.6%) were at-risk drinkers.Conclusion: These findings highlight the need to implement effective prevention measures for at-risk alcohol use among the French population
Functional dyspnea as a risk factor of future persistent physical symptoms: Results from the CONSTANCES cohort study
No full textInternational audienceAimsPersistent Physical Symptoms (PPS) refer to disabling bodily symptoms that persist for several months, regardless of their origins [1]. Transdiagnostic mechanisms such as avoidance behaviors and catastrophizing cognitive representations, commonly observed in functional disorders, may contribute to the persistence of these symptoms1. Functional disorders are characterized by a mismatch between subjective complaints and objective clinical findings. This study aims to explore whether functionalMethodParticipants from the French population-based CONSTANCES cohort with normal spirometry results and no known condition that may cause dyspnea at baseline (2012–2019) were included. Dyspnea was self-reported at baseline with the modified Medical Research Council scale. Spirometry results were classified as normal based on established thresholds published for the CONSTANCES cohort. Multivariable logistic regression models adjusted for age, sex, body mass index, and educational level assessed theResultsThe study involved a total of 17,326 participants, with an average age of 47.8 years, of whom 54.3 % were women. Among them, 2230 (12.9 %) reported functional dyspnea at cohort inclusion, and 6687 (39.0 %) experienced at least one PPS during the COVID-19 pandemic. In multivariable analysis, baseline functional dyspnea was significantly associated to the occurrence of any PPS during the COVID-19 pandemic, with an odds ratio (OR) of 1.79 (95 % Confidence Interval (CI): 1.64–1.97, p < 0.001). This DiscussionFunctional dyspnea may represent a risk factor of PPS regardless of their type or origin, supporting the hypothesis of transdiagnostic mechanisms. Identifying these mechanisms is crucial as they can be addressed through effective treatments such as cognitive-behavioural therapy and gradual physical exercise
Depressive symptoms and vegetarian diets: results from the constances cohort
No full textThe association between depressive symptoms and vegetarian diets is controversial. This study examines the cross-sectional association between depressive symptoms and vegetarian diets while controlling for potential confounders. Among 90,380 subjects from the population-based Constances cohort, depressive symptoms were defined by a score >= 19 on the Centre of Epidemiologic Studies-Depression (CES-D) scale and diet types (omnivorous, pesco-vegetarian, lacto-ovo-vegetarian and vegan) were determined with a food frequency questionnaire. Associations between depressive symptoms and diet were estimated through logistic regressions adjusting for socio-demographics, other foods, alcohol and tobacco consumption, physical activity and health-related concerns; specificity analyses considered the exclusion of any other food group. Depressive symptoms were associated with pesco-vegetarian and lacto-ovo-vegetarian diets in multivariable analyses (Odds-Ratio [95% confidence interval]: 1.43 [1.19-1.72] and 1.36 [1.09-1.70], respectively), especially in case of low legumes intake (p for interaction < 0.0001), as well as with the exclusion of any food group (e.g., 1.37 [1.24-1.52], 1.40 [1.31-1.50], 1.71 [1.49-1.97] for meat, fish and vegetables exclusion, respectively). Regardless of food type, the Odds-Ratio of depressive symptoms gradually increased with the number of excluded food groups (p for trend < 0.0001). Depressive symptoms are associated with the exclusion of any food group from the diet, including but not restricted to animal products
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