1,721,008 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Effects of modulation of signaling pathways on arrhythmogenic cardiomyopathy in the zebrafish model
No full textopenLa cardiomiopatia aritmogena (AC) è un disturbo cardiaco ereditario caratterizzato dalla morte dei cardiomiociti e dalla loro sostituzione con tessuto fibro-adiposo.
Nel 60% dei casi conosciuti, la mutazione colpisce geni che codificano proteine desmosomiali, mentre nell'1-3% dei casi le mutazioni riguardano geni non desmosomiali, come la galectina-3 (LGALS3). L’instabilità desmosomiale può portare all’alterazione di alcune vie di segnale, come Wnt/b-catenina e Hippo/YAP-TAZ, coinvolte nella sostituzione fibro-adiposa del tessuto miocardico. La modulazione farmacologica di queste vie è considerata un possibile approccio terapeutico per migliorare le alterazioni cardiache associate alla patologia.
Lo zebrafish si è dimostrato un ottimo modello per lo studio della malattia e per l’individuazione di nuove molecole e bersagli terapeutici. Attraverso l’utilizzo di una linea mutante nel gene lgals3a è stato possibile osservare la disregolazione delle vie Wnt/b-catenina e Hippo/YAP-TAZ, oltre a un chiaro fenotipo patologico. In particolare, l'agonista della via Wnt/b-catenina SB216763 si è dimostrato efficace nel recupero fenotipico in questa linea mutante. È stata inoltre individuata la concentrazione efficace e non tossica di Verteporfina e XMU-MP-1, rispettivamente antagonista e agonista della via Hippo/YAP-TAZ. Queste molecole verranno utilizzate sulla linea mutante lgals3a per valutare eventuali effetti terapeutici
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Protein CK1BP reduces the aggregation of α-synuclein regardless of phosphorylation to serine S129
No full textreservedLe α-sinucleopatie, tra cui la malattia di Parkinson (PD), sono patologie legate all’accumulo dannoso di α-sinucleina (α-Syn).
La forma aggregata dell’α-Syn, a differenza della sua forma solubile, presenta un’elevata fosforilazione a livello della serina 129 (S129). Tale modificazione sembra interferire con l’aggregazione e l’accumulo della proteina.
La fosforilazione di S129 è operata dalla protein-chinasi CK1 (CK1).
Per verificare il ruolo di tale modifica, è stata sovraespressa una proteina che lega la CK1 (CK1BP) che ne inibisce la funzione. Sono state poi applicate tecniche di Bimolecular Fluorescence Complementation (BiFC) e metodi biochimici per monitorare il livello di fosforilazione dell’α-Syn e lo stato di aggregazione della proteina stessa all’interno di cellule HEK293T.
I risultati ottenuti dimostrano che, come previsto, la CK1BP riduce i livelli di fosforilazione dell’α-Syn , la sua oligomerizzazione e aggregazione e la quantità in generale di proteina insolubile. Analizzando diversi mutanti, però, tra cui mutanti in S129, si è osservato che la riduzione di α-Syn nella sua forma insolubile all’interno della cellula, è indipendente dalla fosforilazione di S129.
Questi risultati implicano che l’inibizione di CK1 potrebbe essere un fronte promettente nell’ambito di nuovi approcci terapeutici per le malattie neurodegenerative in generale, tra cui la malattia di Parkinson
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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