1,721,044 research outputs found
Ethics in field of law. Some reflections
No full textThe work begins, first, with the rebuilding the relationship between law and justice in the european tradition, and then considers the phenomenon of globalization produced by the very impressive progress of the techno-science and its effect on the legal sciences. The Author believes that is highly unlikely that there may be a return to the past. He support the idea of the impossibility of an a realignment between ethics and law. The reference to a common metaphisical point of view doesn't depend, in fact, to an editorial technicality, or still less, to an act of faith. This it was, instead, the mature and conscious fruit of a culture - the Western one - now completely derailed from the tracks followed for more than two thousand years. That context of civilisation is, today, in its final dusk.
The main challenge for the law will be the legislation on the origin and the end of life, the regulamentation of the practice of sexuality and marriage and so on. These issues identify, in fact, the areas where the symbolic meanings become most relevant. Here, every man becames a mistery: very different for each of us. The question is, therefore, if it is possible to pass from the domain of the equality in front of the law, to the protection of the diversity that each person represents
GRK2 at the control shaft of cellular metabolism
No full textG protein receptor kinase 2 (GRK2) has been for years mainly considered the negative regulator of the cardiac β adrenergic signaling. However GRK2 is a ubiquitous molecule and its kinase activity and scaffold properties brought to several investigations which have evidenced its involvement in pathophysiology of extra-cardiac diseases. Later discoveries, moreover, indicated that this molecule is also able to influence other pathways such as insulin signaling by an inhibitory role similar to what described years before on βAR signaling. The importance of this novel function is in particular related to the possibility that this molecule can regulate the cellular metabolism, modifying the ability of cells to utilize different substrates. This hypothesis has been recently investigated in animal model of Heart Failure, evidencing that upregulation of GRK2 leads to alterations of cardiac glucose metabolism in the early stages of the disease. However GRK2 shows increased level also in the early stages of others chronic disease such as Alzheimer's Disease, indicating that these findings could be possibly applied to others cellular system and supporting the emerging idea of GRK2 as master regulator of cellular metabolism. © 2012 Bentham Science Publishers
ANALISI DI ETEROPLASMIE MEDIANTE DHPLC IN UN CASO DI IDENTIFICAZIONE PERSONALE
No full textIl sequenziamento del DNA mitocondriale (mtDNA) è un valido approccio per la tipizzazione dei campioni biologici degradati caratterizzati da uno scarso contenuto di DNA genomico. Ci sono diversi aspetti analitici da considerare nella validazione dei risultati ottenuti mediante analisi dell’mtDNA. Una delle problematiche è connessa al fenomeno dell’eteroplasmia che è quella condizione in cui due o più aplotipi sono presenti in un singolo individuo, cellula o mitocondrio. Le eteroplasmie possono essere di sequenza e di lunghezza. Quest’ultime rendono difficile l’interpretazione dei risultati in quanto determinano uno slittamento del modulo di lettura della sequenza a valle del punto eteroplasmico. Inoltre il sequenziamento diretto, la metodica di prima scelta nell’analisi forense dell’mtDNA, non permette di determinare la lunghezza della variazione nucleotidica delle molecole eteroplasmiche. Nell’identificazione forense la presenza di eteroplasmie influenza l’eventuale corrispondenza tra il campione biologico in esame ed i putativi parenti materni in quanto gli aplotipi a confronto sembrano differire. In questo studio descriviamo la positiva identificazione di un resto scheletrico, il cui profilo mitocondriale presentava un’eteroplasmia di lunghezza, che è stato comparato con i profili ottenuti rispettivamente dalla madre e dal fratello. L’eteroplasmia di lunghezza è stata risolta mediante analisi di cromatografia liquida denaturante ad alta pressione (DHPLC) che ha permesso di discriminare le molecole eteroplasmiche sulla base della loro differenza di lunghezza. La DHPLC è una metodologia largamente utilizzata nel campo della ricerca biologica per rilevare mutazioni genetiche, ma l’estrema sensibilità e le ampie possibilità d’applicazione nell’analisi del DNA la rendono uno strumento utile nel campo dell’identificazione genetica forense
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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