1,721,015 research outputs found
Abnormal pattern of distribution of IgG subclasses in children with chronic hepatitis B virus infection.
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Hypogammaglobulinemia and T cell subsets unbalanced in an infant with perinatal B hepatitis infection. An acquired or congenital immunodeficiency syndrome.
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A solid-phase radioimmunoassay for IgG gliadin antibodies using 125I-Staphylococcal Protein A
No full textA solid-phase radioimmunoassay for IgG gliadin antibodies using 125I-labelled staphylococcal protein A.
No full textA sensitive radioimmunoassay for IgG gliadin antibodies is described. Serum specimens were added to wells of plastic microtitre plates coated with gliadin. After removal of the unbound material, gliadin antibodies were detected by adding 125I-labelled staphylococcal protein A (125I-SpA). Serum specimens from coeliac patients on a normal diet or on a gluten-free diet were tested, as well as sera from an age-matched control group. Measurements to obtain precise quantitative values were made with gliadin antibody-rich serum as reference standard. High titres of gliadin antibodies were found in 18 out of 19 coeliac patients on a normal diet (95%); in patients on a strict gluten-free diet serum values did not exceed 2 S.D. of the control mean. Due to the high sensitivity of the method a low but detectable amount of gliadin antibody was present in the sera of all controls
Heterogeneity of IgA deficiency in childhood.
No full textFifty-one children with total or partial IgA deficiency were compared for clinical and laboratory features. Serum IgG were higher in total IgA deficiency. Moreover, while no subject with partial IgA deficiency showed autoantibodies, 48% of the group with total IgA deficiency showed one or more autoantibodies. These data support the notion that total and partial deficiencies are two distinct entities
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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