1,721,299 research outputs found
Editorial: Coeliac Disease and Women's Reproductive Health: A Lifelong Challenge
No full textNo abstract availabl
Non-biopsy Strategy for the Diagnosis of Celiac Disease in Adults: A Narrative Review
No full textCeliac disease (CeD) diagnosis is a complicated process, requiring a multi-step procedure and a high level of clinical knowledge. Some scientific societies, mainly from Europe and North America, have proposed appropriate guidelines for the diagnosis and management of CeD. Since duodenal biopsy is particularly challenging for children, guidelines of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition, presented in 2012 and updated in 2020, have made it possible to avoid the biopsy in symptomatic pediatric patients with high levels of IgA anti-transglutaminase. Several parallel, similar studies in adults support the non-biopsy strategy. However, several pros and cons exist in applying such a strategy. The present narrative review reports the current evidence and the implication of omitting biopsy in the diagnosis of CeD in adults
Effect of gluten-free diet on faecal microflora composition of women with coeliac disease
No full textCoeliac disease is defined as a permanent intolerance to gliadin in wheat gluten in genetically predisposed individuaks. Recent studies suggest that besides gluten, other environmental factors, such as the composition and metabolic activity of the gastrointestinal flora might be involved in the pathogenesis of the disease
Commentary on the article: Are hepatitis B virus and celiac disease linked?: HBV and celiac disease.
No full textHg(2+) and Cu(2+) interfere with agonist-mediated Ca(2+) signaling in isolated Mytilus digestive gland cells
No full textThe effects of mercury and copper on agonist-mediated Ca-signaling were investigated in isolated cells from the marine mussel: Mytilus galloprovincialis Lam., by single cell fluorescence microscopy. In isolated digestive gland cells, short-term exposure (10 min) to both Hg2+, a highly toxic metal and Cu2+, essential metal, in the nano-low mu M range caused a sustained increase in cytosolic [Ca2+]. The effect of mercury on resting [Ca2+] was stronger than that of copper. The Hg-induced elevation in [Ca2+] seemed to be mainly due to an increased influx through Verapamil-sensitive Ca-channels, whereas the effect of Cu2+ was related to a release from thapsigargin-sensitive intracellular stores. Agonists, such as epidermal growth factor (EGF), bradykinin (BK) and ATP, evoked Ca2+ transients in isolated digestive gland cells through different mechanisms similar to those observed in mammalian cells, demonstrating the presence of common pathways of Ca-mediated cell signaling in both invertebrates and vertebrates. The agonist-mediated Ca2+ response was affected by exposure to Hg2+ and Cu2+ in a concentration dependent manner: both metals significantly reduced the amplitude of the Ca2+ spikes elicited by BK and ATP and decreased the percentage of EGF-responsive cells. The effects of Hg2+ and Cu2+ were apparently independent of their different type of interaction with the mechanisms involved in Ca2+ homeostasis. The results clearly demonstrate that, in marine invertebrate cells, short-term exposure to heavy metal concentrations comparable to environmental exposure levels results in alterations of intracellular Ca2+ homeostasis which compromise the cell response to extracellular stimuli involving Ca-mediated signaling. The mechanisms of heavy metal interference with Ca-homeostasis and signaling are discussed. (C) 2000 Elsevier Science B.V. All rights reserved
Increased COVID-19 lockdown burden in italian adults with gastrointestinal diseases
Full text linkBackground: Coronavirus disease 2019 (COVID-19) causes not only severe illness but also detrimental effects associated with the lockdown measures. The present study aimed to evaluate reported lifestyle changes in a cohort of adults in Italy, including physical exercise, food choices, and psychological wellbeing, after two months of lockdown. Methods: A web survey on social media (Facebook and LinkedIn) of 32 multiple-choice questions aiming to evaluate the impact of the national COVID-19 lockdown in a sample of Italian adults. Results: We received 1378 complete responses (women 68.3%, mean age 39.5 ± 12.5 years). The percentage of participants reporting regular exercise decreased during lockdown (52 vs. 56.5%). The vast majority of people continued to consume the three traditional meals per day, but the consumption of meat, fish, and eggs significantly decreased. Women reported more frequent anxiety, sadness, fear, and feelings of insecurity than men. The factors predicting the worst outcome during the lockdown were being a woman, low education and income, gastrointestinal diseases. Conclusion: The lockdown has had a limited impact on food choices and physical exercise in Italian adults of our series, since most of them made an effort to improve their lifestyle. However, women with gastrointestinal diseases reported more frequent negative feelings and poor adaptation to the lockdown
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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