338 research outputs found
高血壓的基因研究
No full text隨著社會的發展，高血壓的盛行率也跟著升高。數種家族性高血壓已被確定由單基因 突變所造成。這些研究也為高血壓與基因遺傳有關奠下了證據。本態性高血壓被認為 是由多種基因的變異與環境的互動所造成。由於生理與血壓調控有關的基因稱為候選 基因，大多數本態性高血壓的基因研究在於尋找本態性高血壓和候選基因的相關性。 已有報告本態性高血壓與少數候選基因，例如血管張力素原基因，具有有意義的相關 ；然而其相關性仍因種族而有差別。也有利用多個標幟 ( markers) 進行全基因體掃 瞄，並發現數個與本態性高血壓相關的局部區域 (locus)；它們分佈於染色體2p，2q ，5q，6q，15q，17，和18q 等。一般預期高血壓動物之基因研究將有助於尋找本態 性高血壓的致病基因，目前已有約二十個大鼠之高血壓相關的局部區域被定位。高血 壓的基因研究將有助於高血壓的早期診斷、高血壓及心臟血管危險因子的分析、以及 未來更個人化的治療。然而我們也要瞭解高血壓基因研究的複雜性而且高血壓的基因 變異可能因種族而有差異。Hypertension is a rising problem in the developed countries. Some rare familial hypertensive syndromes have been found to be caused by monogenic mutations. Essential hypertension is generally regarded as a complex genetic trait caused by multiple genes. The polygenic effects on blood pressure are modulated by gene-gene and gene- environment interactions. Most investigations for genetic causes of essential hypertension were approached with candidate genes, and a few candidate genes, such as angiotensinogen gene, were reported to be associated with essential hypertension, though the reports from different populations were still conflicting. Genome-wide scans with multiple markers have mapped several loci associated with blood pressure. The loci reported were on chromosomes 2p, 2q, 5q, 6q, 15q, 17, and 18q respectively . However, to date, no genotype had been conclusively linked to essential hypertension. It has long been hoped that genetic research on hypertensive animals, such as rats, will facilitate our understanding of the genetics of human essential hypertension. So far, more than twenty loci were reported to be associated with blood pressure in rats. More understanding of the genetic basis of essential hypertension should be possible in the future and would be expected to help earlier diagnosis, more effective risk factor assessment and more individualized treatment of hypertension. However, the difficulty of genetic analysis for essential hypertension and the possibility of inter- population differences in genetic factors should be kept in mind
Nazi Wireless Propaganda: Lord Haw-Haw and British Public Opinion in the Second World War
No full textThis is the first book devoted exclusively to the analysis of the Nazis' radio effort against the United Kingdom during the Second World War. It traces the development of the German propaganda service and looks to erode the myth surrounding Lord Haw-Haw -the 'superpropagandist'. Propaganda is presented in context: the purposes behind it, the changing patterns, themes, styles, and techniques employed, and the impact upon the target audience and its morale. An analysis of the Nazi wireless broadcasts to Britain for the whole of the Second World War reveals a sophisticated and intelligent propaganda assault on the social and economic fabric of British society. In the end the British failed to succumb to the stupefying effects of Nazi propaganda and they traditionally congratulate themselves upon the national unity which immunised them against it. The author argues that this traditional view disguises a more complex, less appealing reality. Free CD Includes a CD of 24 German wartime broadcasts to Britain Key Features: *Exposition of organisational structure of Nazi wireless for the UK *Detailed analysis of style and content of propaganda broadcasts *Careful and critical re-appraisal of British domestic morale and national unity *CD insert of 24 recordings of Nazi broadcasters including William Joyce, John Amery, Edward Dietze, Norman Baillie-Stewart, Edward Bowlby and 'Black' propaganda broadcast
Selective Surgical Ablation of the Slow Atrioventricular Nodal Pathway by Posterior Perinodal Dissection
No full textAlthough it has been demonstrated that dual atrioventricular (AV) nodal physiology usually forms the basis of AV modal reentry, the anatomic location of the dual nodal pathways remains disputed. The delineation of the surgical anatomy of the reentry circuit is of considerable importance from the viewpoint of surgery and catheter ablation. In a previous report, we proposed that the natural dual atrionodal inputs may in some cases function as dual AV nodal physiology and thereby facilitate the formation of AV nodal reentry. Therefore, if 1 atrionodal input is interrupted, the dual AV nodal physiology may disappear, and the nodal reentry should be crued. Because the posterior perinodal dissection was much safer than the anterior dissection, we performed posterior dissection for patients presenting with dual AV nodal pathways. postoperative follow-up studies showed that the slow pathway disappeared, and no AV nodal reentrant tachycardia could be induced.#A149318
Haw otherwise
No full textAbstrakt
To make this them I have been inspirited by one sentence from one of my main teacher. One day, probably six month ago, he said: ?On the door to our atelier should be written HAW OTHERWISE!? I asked him what he means by it.
He replies:? You study theatre here right. And you study some kinds of way haw to make theatre right. May be we can study here more like haw we can make theatre in otherwise ways. I mean imagine some dramatic situation by you and tell haw much kind processed can be done. After that try imagine some other way haw can be this situation worked some new, some novel.
This start interest me ant this events leading me up to chose this them to my bacillary work. I start from the point that, if I want approach something new I must examine the style what have been already discovered.
To this lead me one book from Raymond Queneau, translate by Barbara Wright ? Exercises in Style. Where author use one short story about the boy who lost his bottom and about his meeting in the bus with his friend. In ninety nine variations styles like changing slang or person witch tell the story or with double beginning.
My first goal was trying something same like Queneau, but implicated in to the theatre. By virtue of this was born idea that may be the point to explore haw otherwise making theatre.
The trailer in on the DVD like appended document
The trailer is not the record from the true performance it is just study material, to inspiration in the case. Trailer was produce by my friend from AMU
Mein etwas anderes Praxissemester : Ein Praktikumsbericht aus Corona-Zeiten
Get PDFEin Praxissemester während des Studiums zu absolvieren, ist an sich schon anstrengend. Doch wie läuft ein Praktikum ab, während ein Virus die ganze Welt im Griff hat? Eine Studentin der HAW Hamburg aus dem Bachelorstudiengang Bibliotheks- und Informationsmanagement berichtet von ihrem Arbeitsalltag im Praktikum bei einem Verlag und weshalb es nicht schlimm ist, die ersten Berufserfahrungen während einer Pandemie zu sammeln.Completing an internship semester during your studies is exciting enough. But how does such an internship work when a virus has the whole world under control? In this report the author recounts how she got her internship at a publishing house, what her everyday work life is like and why it’s not too bad to gain the first professional experience during a pandemic
Cloning a Novel Metallophosphoesterase Gene from a Kidney Cdna Library of Hypertensive Rat
No full textBackground and purpose: Genetic and environmental factors may contribute to the pathogenesis of essential hypertension . To facilitate genetic studies of hypertension and renal disorders, we sought to clone novel genes from a modified, equalized kidney (MEK) cDNA library of a spontaneously hypertensive rat (SHR). Methods: A kidney cDNA library of an SHR was synthesized using the modified equalization method. Inserts of 350 random clones were amplified by polymerase chain reaction (PCR) and sequenced, of which 246 were presumably unknown after being compared against a nonredundant database in the GenBank. The cDNA ends of clone 383 were obtained by rapid amplification of cDNA ends, sequenced, and then analyzed with Translate, Prosite, Profile, SignalP, and TMpred programs. Results: The full- length cDNA was 938 bp, and translated into a 182-amino acid protein. The deduced protein had a metallophosphoesterase domain, a signal peptide at its amino end, a protein kinase C phosphorylation site, and a transmembrane domain. Northern blot analysis revealed that this gene was expressed in the heart, brain, spleen, lungs, liver, skeletal muscles , kidneys and testes of Sprague-Dawley rats. A putative protein of Arabidopsis thaliana shares 62% homology with protein 38S, but the two proteins differ in terms of function and structure. Conclusions: Our results support that protein 38S is a novel membrane metallophosphoesterase, although its function in the kidneys remains to be elucidated. This study also demonstrates the feasibility of using PCR to clone novel genes from our MEK cDNA library
The G-217a Variant of the Angiotensinogen Gene Affects Basal Transcription and Is Associated with Hypertension in a Taiwanese Population
No full textSUMMARY: OBJECTIVE Polymorphisms of the angiotensinogen (AGT ) gene, especially in the promoter region, are in linkage concordance and are associated with hypertension. In this study, we examined the role of AGT promoter polymorphisms, including G-217A, A-6G and M235T variants, and their promoter function in essential hypertension in Taiwanese populations .DESIGN An association study was conducted to assess the genotype distribution between hypertensive patients and normotensive subjects. We also used a transient transfection assay to examine basal transcriptional activity of G-217A and A-6G variants in a mammalian cell system.METHODS Hypertensive subjects (390) and normotensive controls (388) of Taiwanese ethnicity were genotyped for the AGT G-217A, A-6G and M235T variants. Promoter activity was studied by cloning the promoter region (-614 to +41 bp) of AGT into the pSEAP2-Basic reporter vector and performing a transient transfection assay in HuH7 and HepG2 cells.RESULTS The G-217A variant of the AGT gene was significantly associated with hypertension (P = 0.0047), but the A-6G and M235T polymorphisms were not (P = 0.17 and P = 0.33, respectively). Furthermore, the recessive model of homozygous genotype (-217AA) conferred a high risk for hypertension (odds ratio 3.64) in this population. The -217A variant expressed higher transcriptional activity than -217 G in vitro.CONCLUSIONS Our study showed a significant association between the -217A variant of the AGT gene and hypertension. This variant plays a functional role in basal transcription of AGT, and may confer a risk for hypertension in Taiwanese populations
Association of the Renin Gene Polymorphism with Essential Hypertension in a Chinese Population
No full text To study the association of renin gene polymorphism with essential hypertension in the Chinese population, 86 hypertensive and 107 normotensive subjects were enrolled from an epidemiologic survey. Leukocyte DNA was extracted and digested with Hind III and Bgl I restriction enzymes. Southern hybridization was done with digoxigenin- incorporated renin gene probes generated by polymerase chain reaction. The restriction fragments were detected by anti- digoxigenin antibody and enzyme methods. Two Hind III polymorphysms of the renin gene (8.7 kb and 6 .2 kb) were identified. The allele frequences were 129(75%) and 43(25%), respectively, in hypertensives; they were 139(65%) and 75( 35%), respectively, in normotensives(x = 4.074, p=0.044). The genotypes of 8.7/8 .7, 8.7/6.2 and 6.2/6.2 were significantly different between hypertensives and normotensives, being 45(52%), 39(45%), 2(3%) and 48(45%), 43 (40%), and 16(15%), respectively (x = 9.002, p=0.011). The Bgl I polymorphism did not show a difference between hypertensives and normotensives. Thus, we conclude that the renin gene Hind III polymorphysm is associated with hypertension in this Chinese population
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