1,736,054 research outputs found
Chinese history, for the CCP
No full textChina is a civilisational state with a long, contested and layered history. It encompasses within itself the history of the empires, kingdoms, warlords and the Chinese Communist Party (CCP). But the history of China to which the Chinese people and the world is exposed today is sanitised and approved by the CCP. Since 1949, the CCP has taken a lead role in writing and rewriting Chinese history with the sole aim of pushing its own narrative and agenda. This effort is also a crucial exercise through which the CCP advances its identity-building project. Thus, Chinese history has to be uniform and unilateral. No surprise that, as Ian Johnson writes in Sparks: China’s Underground Historians and Their Battle for the Future, “Xi Jinping has made control of history one of his signature policies — because he recognises counter-history as an existential threat.
Correlation between ACPA levels and disease parameters in 32 anti-CCP-positive RA patients.
No full textCorrelation between ACPA levels and disease parameters in 32 anti-CCP-positive RA patients.</p
CCP-ACI on OCD up to 10mm
No full textPurpose: To evaluate clinical, radiographic, and magnetic resonance (MR) results of costal chondrocyte-derived pellet-type scaffold-free autologous chondrocyte implantation (CCP-ACI) in osteochondral defects (ODs) up to 10-mm depth during 5 years of follow-up.Methods: Ten patients with CCP-ACI performed in ODs with depth up to 10 mm were retrospectively analyzed. The minimum follow-up period was 5 years. The median age was 36.5 (range, 20–55) years. The median size and depth of the OD lesion were 4.25 cm2 (range, 2–6) and 7.0 mm (6–9), respectively. Clinically, the International Knee Documentation Committee, Lysholm, and visual analog scale pain scores were evaluated. Radiographically, the hip‒knee‒ankle (HKA) angle and the Kellgren‒Lawrence (K‒L) grade were assessed. On MR imaging, the magnetic resonance observation of cartilage repair tissue (MOCART) 2.0 score and defect depth were evaluated.Results: All average clinical scores improved significantly by 1, 2, and 5 years postoperatively. The average HKA angle and the proportion of K‒L grade did not change significantly within 5 years. The median total MOCART scores were 50 (range, 45–65), 50 (35–90), 57.5 (40–90), and 65 (50–85) at 6 months, 1 year, 2 years, and 5 years postoperatively, respectively (p = 0.001), with significant improvement at 2 years compared to that at 6 months postoperatively. The signal intensity of the repair tissue and subchondral change significantly improved from 10 (range, 10–10) to 12.5 (10–15) (p = 0.036), and from 10 (10–10) to 17.5 (0–20) (p = 0.017), respectively. Significant improvements were seen at 5 years postoperatively for the former and at 2 years postoperatively for the latter. The average depths on MR imaging were 6.7, 6.7, 6.8, 6.6, and 6.6 mm preoperatively and at 6 months, 1 year, 2 years, and 5 years postoperatively with no significant changes (n.s)Conclusion: CCP-ACI provided acceptable mid-term outcomes in ODs up to 10-mm in depth without bone grafting despite of no scaffold. The procedure can be one of minimally invasive treatment options for ODs without scaffold-related problems.</p
Calibration Uncertainties of Tropical Pacific Climate Reconstructions over the Last Millennium
No full textSeveral climate field reconstruction methods assume stationarity between the leading patterns of variability identified during the instrumental calibration period and the reconstruction period. We examine how and to what extent this restrictive assumption may generate uncertainties in reconstructing past tropical Pacific climate variability. Based on the Last Millennium (850-2005 CE) ensemble simulations conducted with the Community Earth System Model and by developing a series of pseudoproxy reconstructions for different calibration periods, we find that the overall reconstruction skill for global and more regional-scale climate indices depends significantly on the magnitude of externally forced global mean temperature variability during the chosen calibration period. This effect strongly reduces the fidelity of reconstructions of decadal to centennial-scale tropical climate variability, associated with the interdecadal Pacific oscillation (IPO) and centennial-scale temperature shifts between the Medieval Climate Anomaly (MCA) and the Little Ice Age (LIA). In contrast, our pseudoproxy-based analysis demonstrates that reconstructions of interannual El Nino-Southern Oscillation (ENSO) variability are more robust and less affected by changes in calibration period.11Nsciescopu
Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort.
Full text linkBACKGROUND: The natural history of prostate cancer is highly variable and it is difficult to predict. We showed previously that a cell cycle progression (CCP) score was a robust predictor of outcome in a conservatively managed cohort diagnosed by transurethral resection of the prostate. A greater need is to predict outcome in patients diagnosed by needle biopsy. METHODS: Total RNA was extracted from paraffin specimens. A CCP score was calculated from expression levels of 31 genes. Clinical variables consisted of centrally re-reviewed Gleason score, baseline prostate-specific antigen level, age, clinical stage, and extent of disease. The primary endpoint was death from prostate cancer. RESULTS: In univariate analysis (n=349), the hazard ratio (HR) for death from prostate cancer was 2.02 (95% CI (1.62, 2.53), P<10(-9)) for a one-unit increase in CCP score. The CCP score was only weakly correlated with standard prognostic factors and in a multivariate analysis, CCP score dominated (HR for one-unit increase=1.65, 95% CI (1.31, 2.09), P=3 × 10(-5)), with Gleason score (P=5 × 10(-4)) and prostate-specific antigen (PSA) (P=0.017) providing significant additional contributions. CONCLUSION: For conservatively managed patients, the CCP score is the strongest independent predictor of cancer death outcome yet described and may prove valuable in managing clinically localised prostate cancer
Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces
No full textThe regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted. Each protein contains an uninterrupted array of from four to 30 examples of the very widely occurring complement control protein (CCP, or sushi) module. The CCP modules mediate specific protein–protein and protein–carbohydrate interactions that are key to the biological function of the RCA and, paradoxically, provide binding sites for numerous pathogens. Although structural and mutagenesis studies of CCP modules have addressed some aspects of molecular recognition, there have been no studies of the role of molecular dynamics in the interaction of CCP modules with their binding partners. NMR has now been used in the first full characterization of the backbone dynamics of CCP modules. The dynamics of two individual modules—the 16th of the 30 modules of complement receptor type 1 (CD35), and the N-terminal module of membrane cofactor protein (CD46)—as well as their solution structures, are compared. Although both examples share broadly similar three-dimensional structures, many structurally equivalent residues exhibit different amplitudes and timescales of local backbone motion. In each case, however, regions of the module-surface implicated by mutagenesis as sites of interactions with other proteins include several mobile residues. This observation suggests further experiments to explore binding mechanisms and identify new binding sites
sj-pdf-1-ccp-10.1177_13591045211033188 – Supplemental Material for Family narratives of lives with persistent physical symptom conditions
No full textSupplemental Material, sj-pdf-1-ccp-10.1177_13591045211033188 for Family narratives of lives with persistent physical symptom conditions by Kimberley Friedner, Wendy Solomons, Halina Flannery and Jenna Harrington in Clinical Child Psychology and Psychiatry</p
Evaluation of Anti-CCP Positive in Patients with Systemic Lupus Erythematosus Referred to Loghman Hakim Hospital between 2007-2017; A Descriptive Study
No full textBackground: It has been found that some patients with Systemic lupus erythematosus (SLE) may have anti-cyclic citrullinated peptide antibodies (anti-CCP), although the clinical significance of such finding is not well established. SLE patients may have joint complaints that are very similar to those observed in rheumatoid arthritis (RA). In early stages of disease, this form of arthritis can be difficult to differentiate from RA, so it is not rare that some SLE patients are initially misdiagnosed to have this disease. This study aims to investigate the prevalence of anti-CCP in SLE patients in Loghman Hakim hospital, Tehran, Iran.Method and Materials: One hundred fourteen SLE patients were studied for anti-CCP. Demographic features and prevalence serum positive Anti-CCP were measured in studied patient.Results: In this study we evaluate 11 men and 103 women. The mean age of patients was 40.26±14.54 y/o. Anti-CCP was positive in 20 of 114 SLE patients. In Anti-CCP positive group also there was 3 men and 17 women with mean age of 45.7±13.Conclusion: We found that 17.5 % of Iranian patients with SLE have positive anti-CCP. Only a careful and prolonged follow-up will reveal the real clinical value of these markers in each patient individually. Key Words: Anti-CCP, Rheumatoid arthritis, Systemic lupus erythematosu
Table_1_PADI4 Polymorphisms Confer Risk of Anti-CCP-Positive Rheumatoid Arthritis in Synergy With HLA-DRB1*04 and Smoking.docx
No full textPeptidylarginine deiminases (PADs) catalyze citrullination, a post-translational modification playing a pathogenic role in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA). The interplay between single nucleotide polymorphisms (SNPs) in the PADI genes and known risk factors for ACPA-positive RA, including smoking, HLA-DR4 and -1, and the PTPN22 R620W polymorphism, was investigated. We typed four PADI2 SNPs, four PADI4 SNPs, and the PTPN22 R620W SNP in 445 Danish RA patients and 533 age-matched healthy controls, as well as in 200 North American RA patients and 100 age- and sex-matched controls. The HLA-DRB1 locus was typed in the Danish cohort. Logistic regression analyses, adjusted for age, sex, smoking status, and PTPN22 R620W, revealed increased risk of anti-CCP-positive RA in carriers of rs11203367(T) (OR: 1.22, p=0.03) and reduced risk in carriers of rs2240335(A) in PADI4 (OR: 0.82, p=0.04). rs74058715(T) in PADI4 conferred reduced risk of anti-CCP-negative RA (OR: 0.38, p=0.003). In HLA-DRB1*04-positive individuals, specifically, the risk of anti-CCP-positive RA was increased by carriage of PADI4 rs1748033(T) (OR: 1.54, p=0.007) and decreased by carriage of PADI4 rs74058715(T) (OR: 0.44, p=0.01), and we observed an interaction between these SNPs and HLA-DRB1*04 (p=0.004 and p=0.008, respectively) Thus, PADI4 polymorphisms associate with ACPA-positive RA, particularly in HLA-DRB1*04-positive individuals, and with ACPA-negative RA independently of HLA-DRB1*04.</p
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