614 research outputs found
Quality of Life Assessment of Chronic Otitis Media Patients Following Surgery
No full textChronic otitis media (COM) is a persistent inflammation of the middle ear. COM often requires surgical management and represents one of the most disabling pathologies in the field of otolaryngology, not only due to hearing loss but also because recurrent otorrhea seriously affects the quality of life (QoL) of patients. The COMOT-15 questionnaire is a reliable, valid and sensitive tool for measuring the QoL of patients with COM. The aim of this study was to evaluate QoL by using the Italian version of the COMOT-15 in COM patients undergoing surgery based on age and different operation techniques. This observational retrospective study involved fifty-two consecutive patients undergoing surgical treatment for COM according to Nadol criteria. Preoperatively (T0) and 12 months after surgery (T1) patients underwent clinical examination, imaging, the Italian version of the COMOT-15 and pure tone audiometry. After surgery, we observed an improvement of QoL in 84.6% of the population. The COMOT-15 overall score, ear symptoms and hearing subscores showed significantly better ratings after surgery in the whole analyzed group. However, the separate analysis of patients operated with open techniques and closed techniques showed a significant improvement in ear symptoms subscore in both groups and a significant improvement in hearing subscore and mental health subscore only in patients operated on with closed techniques. Moreover, we observed a positive correlation between age and Δ-COMOT. This study shows the crucial role of a reliable and suitable questionnaire such as the COMOT-15 in evaluating COM patients, including clinical symptoms, functional and psychological impairments and highlighting a positive correlation between age and COMOT-15 results
Author Correction: Kombucha electronics: electronic circuits on kombucha mats
No full textCorrection to: Scientific Reports, published online 09 June 2023 The original version of this Article contained an error in the spelling of the author Pasquale D’Angelo which was incorrectly given as Passquale D’Angelo. The original Article has been corrected
Spazi pubblici e luoghi condivisi. Progetti architettonici per le città europee
No full textSotto la responsabilità intellettuale e supervisione diretta dell'autore, il volume raccoglie i contributi scritti dai relatori che hanno partecipato al ciclo di conferenze Spazi pubblici e luoghi condivisi. Progetti architettonici per le città europee, ideato da Guya Bertelli e coordinato dal sottoscritto. Il symposium è stato promosso dal Dipartimento di Architettura e Studi Urbani (DAStU) e le conferenze hanno avuto luogo, tra il 2012 e il 2013, presso la sede centrale del Politecnico di Milano e presso il Campus Arata del Polo Territoriale di Piacenza.
Le quattro giornate di studio sono state organizzate in modo tale che il dibattito prendesse in esame, nell’ambito della stessa giornata, una coppia di città europee, rendendo possibile un fertile confronto. I contributi dei relatori - Enric Massip Bosh e Carlos Garcia Vazquez; Hervé Dubois e Gill Novarina; Stefan Vieths e Michele Giovanni Caja; Francisco Arqués Soler e Maria Vittoria
Capitanucci - sono articolati in quattro diversi capitoli. Ciascun capitolo presenta gli interventi della relativa giornata di studio ed è aperto da un’introduzione, e seguito da una conclusione a firma del coordinatore della giornata. I quattro capitoli sono inoltre preceduti da un’introduzione di Gabriele Pasqui e dai saggi di Guya Bertelli, Michele Roda e del sottoscritto che riflettono, attraverso uno sguardo critico, sul ruolo e sul significato dello spazio pubblico nella città contemporanea.Under the intellectual responsibility and direct supervision of the author, the publication collects contributions by the lecturers in the series of conference Public spaces and shared places. Architectural projects for the European cities created by Guya Bertelli and coordinated by Pasquale Mei. The symposium was sponsored by the Department of Architecture and Urban studies (DAStU) and the conferences have been organized in 2012 and 2013 at Politecnico di Milano, Campus Leonardo, and at Arata Campus, in the Territorial Campus of Piacenza. The debates were part of the four working days; each one was dedicated to an interesting comparison between two European cities. The contributions of the lecturers - Enric Massip Bosh and Carlos Garcia Vazquez; Hervé Dubois and Gill Novarina; Stefan Vieths and Michele Giovanni Caja; Arqués Francisco Soler and Maria Vittoria Capitanucci - are divided into four different chapters. Each chapter presents the intervention of a specific day and is opened by the introduction, and followed by a conclusion by the coordinator of the same day. The four chapters are introduced by a forward by Gabriele Pasqui and essays by Guya Bertelli, Michele Roda and Pasquale Mei, reflecting a critical view on the role and the meaning of the public space in the contemporary city
La Clauis Physicae (316-529) di Honorius Augustodunensis. Studio e edizione
No full textThe Clauis Physicae is a Latin epitome of John Scottus Eriugena’s Periphyseon written by the prolific author of the Western twelfth-century Church, Honorius Augustodunensis. It therefore constitutes one of the most important witnesses to medieval Eriugenism. This volume contains the first critical edition of Clauis Physicae (316-529), a work of great interest in matter both of ecdotics, for the reconstruction of the text, which reproduces almost verbatim the Book V of Periphyseon, and of theoretics, for the illustration of the themes typical of neo-Platonic philosophy in Eriugena’s Christian eschatology, among which is the doctrine of the return of all created natures into the original source of God.
Integrating the pars prior of the Clauis Physicae (1-315), edited by Paolo Lucentini, Edizioni di Storia e Letteratura, Rome 1974, the present edition of the pars altera of the Clauis Physicae (316-529), edited by Pasquale Arfé, provides finally the possibility of a complete reading of Periphyseon’s special textual interpretation by Honorius Augustodunensis
Raman spectroscopy as a new tool for early detection of bacteria in patients with cystic fibrosis
No full textRespiratory infections represent a major threat for people affected by cystic fibrosis, leading to
pulmonary deterioration and lung transplantation as a therapeutic option for end-stage
patients. A fast and correct identification of pathogens in airway fluid of these patients is
crucial to establish appropriate therapies, to prevent cross-infections and, ultimately, to
preserve lung function. In this study, we used Raman spectroscopy to reveal bacteria in the
sputa of patients such as Pseudomonas aeruginosa and Staphylococcus aureus, which are
among the earliest and the most frequent bacteria affecting cystic fibrosis patients. We found
that Raman analysis, combined with principal component analysis, is able to provide a correct
identification of these bacteria, with a global accuracy higher than 95%. Interestingly, bacterial
identification is performed by analysing patients’ sputa as a whole, avoiding, therefore,
time-consuming procedures involving bacterial isolation or even bacterial cultures. This study
suggests that Raman spectroscopy could be a suitable candidate for the development of
innovative and non-invasive procedures for a fast and reliable identification of respiratory
infections in cystic fibrosis patients
A subjetividade jurídica internacional na história da doutrina brasileira: oposições entre Nação e Estado nos séculos XIX e XX
No full textTCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Jurídicas. Direito.Com o objetivo de observar de que maneira a pergunta “quem é o sujeito de direitos na comunidade internacional” foi respondida, ressaltando as oposições entre Nação e Estado, o presente trabalho investigou o pensamento de Pasquale Stanislao Mancini, descrevendo como que, utilizando por fundamento do direito internacional o Princípio da Nacionalidade, o jurista italiano propõe a exclusividade da Nação como sujeito de direito internacional, em oposição ao Estado e de que maneira isto influenciou os autores da escola italiana de direito internacional, em especial Terenzio Mamiami e Pasquale Fiore. A seguir, adentra-se na doutrina brasileira da segunda metade do século XIX para verificar de que forma se deu a oposição entre os conceitos de Nação e Estado. Posteriormente, debruçando-se por sobre o pensamento de Lafayette Rodrigues Pereira e Clóvis Beviláqua, busca-se demonstrar como se tratou a problemática da subjetividade jurídica internacional no Brasil durante o início do século XX. Finalmente, verifica-se qual termo passou a ser adotado majoritariamente pela doutrina brasileira, até se encontrar um autor nacional que não mais defenda o exclusivismo de um ente político em específico, mas, consciente das diversas configurações históricas pelas quais passou a comunidade internacional, aceite uma pluralidade de sujeitos. Busca-se, ainda, ao longo de todo trabalho reforçar as continuidades e rupturas entre os diversos autores analisados, além de se proporem, quando cabíveis, críticas às concepções apresentadas.In order to observe how the question “who is the subject of rights in the international community” was answered, focusing on the contrasts between Nation and State, the present study investigated the thought of Pasquale Stanislao Mancini, describing how, using the Principle of Nationality as the basis of international law, the Italian jurist proposes the exclusivity of the Nation as a subject of international law in opposition to the State and how it influenced the authors of the Italian school of international law, especially Terenzio Mamiami and Pasquale Fiore. Hereafter, enter in the Brazilian doctrine of the second half of the nineteenth century to verify how occurred the opposition between the concepts of Nation and State. Posteriorly, looking at the thought of Lafayette Rodrigues Pereira and Clóvis Beviláqua, we seek to demonstrate how the problem of international juridical subjectivity was treated in Brazil during the early twentieth century. Finally, we verify which term was mostly adopted by Brazilian doctrine, until find a national author who no longer defends the exclusivity of a political entity in specific, but, aware of different historical settings of the international community, accepts a plurality of subjects. We also try throughout the study to highlight the continuities and changes between the various authors analyzed, and to propose, as appropriate, critical to the concepts presented
Integrazione tra approcci spettroscopici e metodologie avanzate di spettrometria di massa per lo studio dell'interazione tra proteine e leganti idrofobici e degli aspetti strutturali di queste interazioni. PRIN 2004.
No full textPasquale Ferranti is associate professor at the Department of Food Science (University of Naples Federico II) and fellow researcher at the Center of Mass Spectrometry and Biomolecular Proteomics at the Institute of Food Science-CNR in Avellino. In the past years he has carried out full-time research at the Department of Biochemistry, Imperial College of Technology, London: applications of mass spectrometry to the structural analysis of carbohydrates and glycoproteins. He is a Teacher in the courses of Functional Food Components for both the degree in Food Science and Technology in the Faculty of Agronomy. He is author of over 120 research papers (over 80 on international Journals). Dr. Ferranti has been invited speaker in international meetings on mass spectrmetry as well as protein chemistry in these years, and invited teacher in international schools including the NATO-ASI School on Mass Spectrometry held in 1990, 1993, 1996, 2001; the Protein Science School held in Urbino during 1994-96; the school on Proteomics held at the University of Tuscia in 2000 and 2001. He is scientific supervisor of the projects “Development and validation of methods for the dosimetry of gluten in foods for the evaluation of flour quality and the safety of celiac patients”; “Identifcation and recovery of high value bioactive components in milk whey”; “Identification of protein quality markers in cheese production of Regione Campania” all granted by the Regione Campania;
The following subjects have mainly been studied by professor Ferranti:
A. Analysis of the primary structure of proteins and studying post-translational modifications by the use of automated sequence as well as mass spectrometry.
B. Study of covalent and non-covalent interaction of biomolecules by mass spectrometry.
C. Determination of the sequence of proteins of nutritional interest and analysis of polymorphism in animal as well as vegetal proteins
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