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    On the mean field approximation of a stochastic model of tumour-induced angiogenesis

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    In the field of Life Sciences, it is very common to deal with extremely complex systems, from both analytical and computational points of view, due to the unavoidable coupling of different interacting structures. As an example, angiogenesis has revealed to be an highly complex, and extremely interesting biomedical problem, due to the strong coupling between the kinetic parameters of the relevant branching-growth- A nastomosis stochastic processes of the capillary network, at the microscale, and the family of interacting underlying biochemical fields, at the macroscale. In this paper, an original revisited conceptual stochastic model of tumour-driven angiogenesis has been proposed, for which it has been shown that it is possible to reduce complexity by taking advantage of the intrinsic multiscale structure of the system; one may keep the stochasticity of the dynamics of the vessel tips at their natural microscale, whereas the dynamics of the underlying fields is given by a deterministic mean field approximation obtained by an averaging at a suitable mesoscale. While in previous papers, only an heuristic justification of this approach had been offered; in this paper, a rigorous proof is given of the so called 'propagation of chaos', which leads to a mean field approximation of the stochastic relevant measures associated with the vessel dynamics, and consequently of the underlying tumour angiogenic factor (TAF) field. As a side, though important result, the non-extinction of the random process of tips has been proven during any finite time interval

    Analysis of a reaction-diffusion system modelling man-environment-man epidemics

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    In this paper an old model for the temporal and spatial evolution of orofecal transmitted disease is reexamined

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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