1,720,997 research outputs found
Comparison of the influence on some spirometric parameters produced by aerosol administration of reproterol and salbutamol to patients with chronic obstructive lung disease. Reproterol exerts a favorable action on bronchial obstruction, comparable but more prolonged than that of salbutamol [EFFETTI DELLA SOMMINISTRAZIONE DI REPROTEROLO AEROSOL DOSATO SU ALCUNI PARAMETRI SPIROMETRICI IN PAZIENTI AFFETTI DA BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA. CONFRONTO CON IL SALBUTAMOLO]
No full textComparison of the antihypertensive activities of xipamide and chlorthalidone: A double-blind, randomized, crossover trial
No full textThe effectiveness of a new potent diuretic, xipamide, was evaluated in the treatment of patients with mild to moderate essential hypertension. The effects of daily doses of 40 mg xipamide were compared with those of 100 mg chlorthalidone with respect to systolic and diastolic blood pressure, using a double-blind crossover design. Patients received each drug for 6 weeks, the order of treatments being at random and the periods being separated by a 'washout' period of 7 days. The results showed that xipamide was as effective as chlorthalidone in controlling blood pressure, both in the upright and supine positions, and when administered after chlorthalidone produced a further reduction. No such further reduction occurred when chlorthalidone was given after xipamide. Serum electrolyte changes induced by the two diuretics were comparable. Both drugs were well tolerated and caused few side-effects
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Effect of mexiletine on reperfusion-induced ventricular arrhythmias - comparison with lidocaine
No full textThirty mongrel dogs underwent proximal occlusion of the left anterior descending
coronary artery to evaluate the comparative action of mexiletine and lidocaine on
ventricular arrhythmias during myocardial reperfusion. Heart rate, arterial blood
pressure, left ventricular end-diastolic pressure and dp/dt max were evaluated
before and at the 20th and 25th min after coronary occlusion; at the 25th min
coronary occlusion was removed. Dogs were randomly assigned to one of the
following groups of 10: 1) control group; 2) dogs given i.v. mexiletine; 3) dogs
given i.v. lidocaine. As expected, during ischemia, myocardial contractility
decreased after mexiletine or lidocaine administration more than in the control
group. Ventricular arrhythmias during myocardial reperfusion occurred in 9 dogs
of the control group (ventricular tachycardia in 2 cases and ventricular
fibrillation in 7 cases). Among dogs given mexiletine only 1 had ventricular
fibrillation (p less than 0.001 vs control). Six of the 10 dogs given lidocaine
had ventricular arrhythmias (ventricular tachycardia in 5 cases and ventricular
fibrillation in 1 case) (p = ns vs control group; p less than 0.05 vs mexiletine
group). Thus mexiletine and lidocaine had similar effects on cardiac function
during myocardial ischemia and only mexiletine showed a protective effect against
reperfusion ventricular arrhythmias
Role of increased cholinergic activity in reperfusion induced ventricular arrhythmias.
No full textThe effect of increased cholinergic activity on reperfusion induced ventricular
arrhythmias was studied in alpha chloralose anaesthetised dogs by administering
neostigmine during a 25 min occlusion of the anterior left descending coronary
artery. The dogs were divided into five groups, each of 10 animals: the control
group received only saline solution; group 1 neostigmine 0.03 mg.kg-1 iv at 20
min of coronary occlusion (that is, 5 min before reperfusion); group 2 atropine
0.4 mg.kg-1 iv at 10 min of coronary occlusion and neostigmine 0.03 mg.kg-1 iv at
20 min; and group 3 neostigmine 0.03 mg.kg-1 iv at 20 min of coronary occlusion
and at the same time underwent atrial pacing at the same rate as that of the
sinus node just before neostigmine administration. In group 4 heart rate was
slowed (junctional rhythm) by destroying the sinus node at 20 min of coronary
occlusion. The results obtained showed that ventricular tachycardia and
fibrillation, which occur at the beginning of reperfusion, were significantly
less frequent in group 1 (p less than 0.001) and in group 4 (p less than 0.001).
The protective action of neostigmine was abolished by previous administration of
atropine (group 2) and modified by preventing the decrease in the heart rate by
atrial pacing (group 3). In group 3 ventricular tachycardia was more frequent but
the incidence of ventricular fibrillation was reduced significantly compared with
the control and atropine groups. Thus cholinergic activity has a protective role
in reperfusion arrhythmias by decreasing the heart rate before release of the coronary occlusion and therefore reduces the incidence of ventricular fibrillation
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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