5,487 research outputs found
Sexual offenses and the brain
No full text: Sexual offenses are a great concern worldwide due to the devastating physical and psychological consequences the victims of such crimes often experience. It is an important task to investigate potential mechanisms that may underlie sexual offending and predispose an individual for such antisocial behavior. Advanced techniques in neuroscience are increasingly used to uncover biomarkers in psychiatric disorders and organic brain disease. As this type of research is flourishing, preliminary studies with the aim to explore the neural basis of sex offenders have started to appear. To this purpose, researchers began to study the brain's structural and functional changes and the neurocognitive profiles of sex offenders, in comparison to nonoffenders and nonsex offenders, or among different subtypes of sex offenders. Most of the research to date has focused on pedophilia, with some inconsistent findings, which hampers the translation of the results into the forensic and clinical context. Any attempt to increase convergent evidence may profit from the harmonization of data analysis and avoidance of methodological inconsistencies, which can account for the different results across studies. Today, uncovering the neural basis of sex offences has to become a priority, not only for clinical interventions, but might also be important knowledge for crime prevention
Comportamento pedofilico idiopatico e acquisito: un’analisi critica
No full textAcquired pedophilia is a rare but underestimated condition. Acquired pedophilic behavior refers to the insurgence of pedophilic tendencies as result of a neurological disorder, that cause a fracture between behaviors observed prior and after the brain insult. Acquired pedophilia widely differs from idiopathic pedophilia. The current review of the literature summarizes the actual knowledge on the differences between acquired and idiopathic pedophilia in the following aspect: etiology, neural correlates, modus operandi, possible treatments and legal consequences. We conclude underlying that appreciating the possibility of an acquired origin of pedophilic behavior is of utmost importance, for clinical and forensic reasons. An interdisciplinary approach must be acted in all cases under observation.La pedofilia acquisita è una condizione rara ma sottostimata. Per comportamento pedofilico acquisito si intende l’insorgenza di tendenze pedofiliche come conseguenza di un disturbo neurologico che causa una frattura comportamentale tra i comportamenti manifestati dal soggetto prima e dopo l’insorgenza del danno cerebrale. La pedofilia acquisita differisce dalla pedophilia idiopatica. Questa revisione della letteratura riassume le conoscenze attuali sulle differenze tra pedofilia acquisita e idiopatica nei seguenti aspetti: eziologia, correlati neurali, modus operandi, possibili trattamenti e conseguenze legali. Il lavoro si conclude sottolineando che essere consapevoli della possibile origine neurologica della pedofilia è estremamente importante, sia dal punto di vista clinico e forense. Un approccio interdisciplinare dovrebbe essere adottato in tutti i casi sotto osservazione
Diskussion mit Cristina Morales
No full textInvitation to an informal lunch talk with the the seventeenth Friedrich Dürrenmatt Guest Professor, the Spanish author and activist Cristina Morales. We will prepare soups with bread and hope for lively discussions and food for thought
Forkhead Transcription Factor FOXP3 Upregulates CD25 Expression through Cooperation with RelA/NF-κB
No full textConsiderable evidence supports the prediction that CD25 is directly regulated by the forkhead transcription factor FOXP3. However, given that CD25 is normally upregulated in activated T cells, regardless of whether they express FOXP3, this issue has still to be definitively demonstrated. Here we describe that FOXP3, induced by CD28 signals in human CD4+CD25- T lymphocytes, synergizes with RelA on a regulatory region of Cd25 promoter to mediate the transcriptional activation of Cd25 gene. We found that a striking feature of this regulatory region is the presence of a κB site and of two tandem copies of a non-consensus FOXP3 binding site separated at 5′ ends by 19 nucleotides that allow FOXP3 and RelA binding to DNA and their physical interaction. The occupancy of the two FOXP3 binding sites in conjunction with RelA binding site occupancy allows FOXP3 to function as a positive activator of Cd25 gene. Indeed mutations of both FOXP3 binding sites such as mutation of κB site on Cd25 promoter abolished FOXP3 activatory functions. Moreover, FOXP3 mutation ΔE251, that compromises FOXP3 homotypic interactions, failed to trans activate Cd25 promoter, suggesting that both FOXP3 DNA binding and dimerization are required to trans activate Cd25 promoter. These findings identify a novel mechanism by which RelA and FOXP3 cooperate to mediate transcriptional regulation of target genes and characterize a region on Cd25 promoter where FOXP3 dimer could bridge intramolecularly two DNA sites and trans activate Cd25 gene. © 2012 Camperio et al
FOXP3 induced by CD28/B7 interaction regulates CD25 and anergic phenotype in human CD4+CD25- T lymphocytes
No full textCristina Bautista, colombiana e indígena, lideresa social y tejedora de pensamiento y comunidad / Cristina Bautista, a Colombian and indigenous social leader, community thinker, and weaver of thoughts
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This is a tribute to activist, Cristina Bautista in Colombia. She was an indigenous woman working on the rights of women in her community and on land rights. The author traces Cristina's life and the Hilando pensamientos (Weaving Thoughts), the Nasa women's movement. Her activism was powerful, and Cristina was killed in 2019 by armed actors. 
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‘La casa de la escritura’: entrevista con Cristina Siscar Buenos Aires, 13 de marzo 2009
No full textThis is an interview with the Argentinian author, Cristina Siscar
"A Stony Language: Zukofsky's Zadkine", in The Idea and The Thing in Modernist American Poetry (editor Cristina Giorcelli) - "Preface" to The Idea and The Thing in Modernist American Poetry (ed. Cristina Giorcelli).
No full textIn the "Preface" -- the editor and author of an essay-- Cristina Giorcelli explains how, thanks to Heidegger's, Schopenhauer's and Wittgenstein's categories, Modernist American poets gave visual, phonetic, and iconic relevance and, thus, "concreteness" to language in order, on the one hand, to avoid Romantic sentimentalism and Symbolic conventionalism, and, on the other, to enhance the word's semantics and polyhedrical value. The volume is eminently interdisciplinary in that poetry is studied in relation to: philosophy, the visual arts, history, and the world of classic myth. In her essay (pp.109-139) on "A Stony Language: Zukofsky's Zadkine," Cristina Giorcelli examines a long composition by the "objectivist" poet, Louis Zukofsky who -- at a crucial time in his highly innovative career -- wrote an ekphrasis centered on a sculpture by the Russian expatriate and political refugee in the United States, Ossip Zadkine, entitled "La Prisonniere." The poem has never been examined before. The essay is a close, learned analysis of the way in which Zadkine's sculpture -- with its distortions and reversals, its cleavages, and its spatial-dynamic relationship between mass and volume -- is rendered by Zukofsky's words, rhymes, rhythm, etymological and cross-linguistic puns, metonymies, anagrams, echoes, and mythological references. Furthermore, while this analysis traces Zadkine's tie to Vladimir Tatlin's aesthetics, it illustrates Zukofsky's bond to Apollinaire, James Joyce, and Gertrude Stein, while also showing Zukofsky's extraordinary and long lasting originality and impact on contemporary poets (paramount among them, the so called L=A=N=G=U=A=G=E Poets)
The importance of the human factor during the evolution of SARS-CoV-2 pandemic: the successful case of the Italian strategy
No full textIn Italy, 311,364 cases and 35,851 deaths of people who tested positive for SARS-CoV-2 were registered as of September 29th, 2020. To avoid the spreading of the virus, mathematical models predicting the course of infection’s spread become the basis to plan stringent countermeasures. We applied a published algorithm to real data up to September 27th, modeling two scenarios where predicted and real data were compared: a conservative scenario with a lockdown still ongoing and a scenario reflecting what actually happened in Italy, where the lockdown has been removed. Results revealed that the number of individuals in life-threatening condition is much lower than predicted, as well as the number of symptomatic individuals. Contrarily, the number of asymptomatic individuals is much higher than predicted. This suggest that human beings are not passive victims, but active fighters able to change the course of the infection creating adaptive strategies against the infection’s spread
BOOK REVIEW ON ELEMENTS OF URBANISM; AUTHOR: ALPOPI CRISTINA
No full textIn september 2008 has been published at Universitaria Publishing House of Bucharest, Romania, the book "Elements of Urbanism", written by Cristina Alpopi. Cristina Alpopi, Associate Professor at Academy of Economic Studies, Bucharest, Romania, is a dedicated researcher and a prolific author of articles and papers in the field of Urbanism. The book contains 8 chapters very rich in concepts, theories, ideas, representing a contribution to the development of the literature in the field of urbanism.
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