1,720,962 research outputs found
Hepatocellular carcinoma metastatic to the kidney mimicking renal oncocytoma
No full textBACKGROUND: Renal metastases of hepatocellular carcinoma (HCC) are very rare. To our knowledge only five cases have been reported to the present; all had a well-known primary HCC. METHODS: We describe the clinico-pathological features of a rare case of HCC metastatic to the kidney in which the renal mass was the clinical debut of disease. The patient was a 54-year-old woman previously submitted to orthotopic liver transplantation, who underwent left nephrectomy for a renal mass. RESULTS: Histologically, the tumor was composed mainly of epithelioid cells with homogeneous acidophilic cytoplasm resembling oncocytoma or primary renal carcinoma with oncocytic features. A correct diagnosis was made on the basis of positive immunostaining for hepatocyte paraffin 1. CONCLUSIONS: Metastasis to the kidney is a rare complication that should be considered whenever a renal mass is present in patients with HCC. Since HCC may histologically resemble primary renal tumors such as oncocytoma, pathologists must be aware of this possibility above all in patients referred for liver transplantation and treated with immunosuppressant drugs. Immunohistochemistry is particularly helpful to establish a precise diagnosis in cases of doubt. © 2010, Hepatobiliary Pancreat Dis Int. All rights reserved
Hashimoto thyroiditis as a manifestation of struma ovarii
No full textWe describe clinicopathologic features, laboratory data, and imaging and therapeutic management of a rare case of Hashimoto thyroiditis arising in struma ovarii. The patient was a 38-year-old woman with clinical symptoms of hyperthyroidism. Laboratory data showed elevated levels of total and free thyroxine, low thyrotropin level, and positive specific antithyroid antibodies without ultrasound evidence of morphologic abnormalities of the thyroid gland. Pelvic ultrasonography and magnetic resonance imaging of the abdomen showed bilateral solid ovarian masses containing cystic and fat areas diagnostic of teratoma. The performance of a I whole-body scan demonstrated a focus of intense uptake in the pelvis with minimal residual thyroid gland. The patient had a bilateral oophorectomy, and histologic examination revealed thyroid tissue in both masses with all the features of Hashimoto thyroiditis in the right ovary. Symptoms of hyperthyroidism diminished after the surgery, and the thyroid hormone levels and antithyroid antibodies were in the normal range in 1 month. The present case further confirms the rare occurrence of Hashimoto thyroiditis in struma ovarii. This diagnosis should be suggested in the differential diagnosis of patients with symptoms of thyroid disease and a normal thyroid gland. Copyrigh © 2010 by Lippincott Williams & Wilkins
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Monotypic epithelioid angiomyolipoma of the adrenal gland: an unusual site for a rare extrarenal tumor
No full textEpithelioid angiomyolipoma (AML) is an uncommon renal mesenchymal tumor with malignant potential and is frequently associated with tuberous sclerosis. Extrarenal AMLs are rare, and to the best of our knowledge, this is the first reported case of a primary monotypic epithelioid AML of adrenal gland in a patient without evidence of tuberous sclerosis. The patient is a 42-year old man who presented with retroperitoneal hemorrhage resulting from spontaneous rupture of adrenal mass. Histologically, the tumor showed a prominent component of epithelioid smooth muscle cells with slightly pleomorphic nuclei, sometimes with prominent nucleoli and eosinophilic cytoplasm resembling oncocytic tumors. Epithelioid cells were positive for melanoma (HMB45 and positive MelanA) and smooth muscle markers (α-smooth muscle-specific actin), but not for epithelial markers (cytokeratin, EMA). Differential diagnosis from renal cell carcinoma, adrenal gland carcinoma, and metastatic carcinoma is often challenging because of its epithelioid morphology. Because primary and secondary malignant tumors are much more common and aggressive neoplasms, establishing the correct diagnosis has important therapeutic and prognostic implications. © 2009 Elsevier Inc. All rights reserved
Valutazione diagnostica post-chirurgica di pazienti con carcinoma tiroideo differenziato: confronto tra ecografia, scintigrafia con iodio-131 e PET con fluoro-18 fluorodesossiglucosio.
No full textObjective. The aim of this study was to compare the results of ultrasound (US), “whole-body” scintigraphy with iodine-131 (WBS) and PET with fluorine-18 deoxyglucose (FDG-PET) in patients with differentiated thyroid carcinoma (DTC) during the post-surgical follow-up. Materials and methods. Thirteen patients (3M, 10F) were evalueted by neck US, WBS and FDG-PET; all patients had near-total thyroidectomy. In each patient 6 anatomic regions (right and left thyroid beds, right and left cervical areas, right and left up-clavear compartments) were investigated for a total of 78 anatomic regions; distant metastases have been considered as a different group in the analysis and were investigated by WBS and FDG-PET. Imaging findings were compared with standard reference data such as: biopsy (n=4) or clinical-radiological (n=9) results. Results. In the neck, US, FDG-PET and WBS showed concordant results in the majority (91%) of sites of which 70 with no lesions, while in a patient with left cervical metastatic lymph node imaging results were concordant for abnormal findings; in the remaining 9% (n=7) of cases, imaging results were discordant; in particular, tumor lesions were detected only by US (n=3), by US and WBS (n=1) and only by FDG-PET (n=3). The detection of distant metastases by FDG-PET and WBS was concordant in the majority (77%) of patients as normal images (n=9), while in a case imaging result were concordant for the presence of tumor lesion. In the last three patients the results were discordant; in particular, in two patients only WBS detected distant metastases, while in the last patient only FDG-PET showed tumor lesion. Conclusions. Results of our work show a fundemental role of US for the evaluation of the neck in patient affected by DTC during the post-surgical follow-up. WBS is useful to determine the differentiation of tumor lesions, for the identification of the residual thyroid gland and for the search of distant metastases. FDG-PET has an important role in cases of undifferentiated DTC in which WBS and thyreoglobulin assay are not able to detect tumor lesions
Valutazione diagnostica post-chirurgica di pazienti con carcinoma tiroideo differenziato: confronto tra ecografia, scintigrafia con iodio-131 e PET con fluoro-18 fluorodesossiglucosio.
No full textObjective. The aim of this study was to compare the results of ultrasound (US), “whole-body” scintigraphy with iodine-131 (WBS) and PET with fluorine-18 deoxyglucose (FDG-PET) in patients with differentiated thyroid carcinoma (DTC) during the post-surgical follow-up. Materials and methods. Thirteen patients (3M, 10F) were evalueted by neck US, WBS and FDG-PET; all patients had near-total thyroidectomy. In each patient 6 anatomic regions (right and left thyroid beds, right and left cervical areas, right and left up-clavear compartments) were investigated for a total of 78 anatomic regions; distant metastases have been considered as a different group in the analysis and were investigated by WBS and FDG-PET. Imaging findings were compared with standard reference data such as: biopsy (n=4) or clinical-radiological (n=9) results. Results. In the neck, US, FDG-PET and WBS showed concordant results in the majority (91%) of sites of which 70 with no lesions, while in a patient with left cervical metastatic lymph node imaging results were concordant for abnormal findings; in the remaining 9% (n=7) of cases, imaging results were discordant; in particular, tumor lesions were detected only by US (n=3), by US and WBS (n=1) and only by FDG-PET (n=3). The detection of distant metastases by FDG-PET and WBS was concordant in the majority (77%) of patients as normal images (n=9), while in a case imaging result were concordant for the presence of tumor lesion. In the last three patients the results were discordant; in particular, in two patients only WBS detected distant metastases, while in the last patient only FDG-PET showed tumor lesion. Conclusions. Results of our work show a fundemental role of US for the evaluation of the neck in patient affected by DTC during the post-surgical follow-up. WBS is useful to determine the differentiation of tumor lesions, for the identification of the residual thyroid gland and for the search of distant metastases. FDG-PET has an important role in cases of undifferentiated DTC in which WBS and thyreoglobulin assay are not able to detect tumor lesions
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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