186,556 research outputs found
Stabilization for Iwasawa modules in Z_p-extensions
No full textLet K/k be a Z_p-extension of a number field k with layers k_n. Let i_n,m be the map induced by inclusion between the p-parts of the class groups of k_n and k_m (m>n). We study the capitulation kernels H_n,m:=ker(i_n,m) and H_n:=\cup_m>n H_n,m to give some explicit formulas for their size and prove stabilization properties for their orders and p-ranks. We also briefly investigate stabilization properties for the cokernel of i_m,n and for the kernels of the norm maps and point out their relations with the nullity of the Iwasawa invariants for K/k
Caricatures and Prop Oriented Make-Believe
No full textA caricature can reveal an aspect of its subject that a more faithful representation would fail to render: by depicting a slow and clumsy person as a monkey one can point out such qualities of the depicted subject, and by depicting a person with quite big ears as a person with enormous ears one can point out that the depicted person has rather big ears. How can a form of representation that is by definition inaccurate be so representationally powerful? Figurative language raises a similar puzzle. Metaphors, taken at face value, are usually false: men are not wolves. The same goes for hyperbolic talk: Putnam did not change his position one billion times in his career. Still, figurative language is expressively powerful: by saying that human beings are wolves or that Putnam changed his position one billion times in his career one conveys, in a very vivid way, some true information about the world (something concerning the facts that human beings are cruel and that Putnam frequently changed opinion). Kendall Walton (1993) provides an elegant explanation of the expressive utility of figurative language by linking metaphor and prop oriented make-believe. We explore the hypothesis that the theory of prop oriented make-believe can also explain the representational efficacy of caricatures.Elisa Caldarola acknowledges financial support of her work by the University of Padova through the project: Disagreement. A Pluralist Approach (2015–2017).
Matteo Plebani acknowledges financial support of his work by the Spanish Ministry of Economy and Competitiveness and FEDER through the project: The
Explanatory Function of Abstract Objects: Their Nature and Cognoscibility, FFI2013-41415-PS
Stabilization in non-abelian Iwasawa theory
No full textLet K/k be a Z_p-extension of a number field k, and denote by k_n its layers. We prove some stabilization properties for the orders and the p-ranks of the higher Iwasawa modules arising from the lower central series of the Galois group of the maximal unramified pro-p-extension of K (resp. of the k_n)
Caldarola (Carlo) Christianity: the Japanese Way. Monographs and Theorical Studies in Sociology and Anthropology in Honour of Nels Anderson
No full textYamane Hiroko. Caldarola (Carlo) Christianity: the Japanese Way. Monographs and Theorical Studies in Sociology and Anthropology in Honour of Nels Anderson. In: Archives de sciences sociales des religions, n°49/2, 1980. p. 243
Caldarola (Carlo) Christianity: the Japanese Way. Monographs and Theorical Studies in Sociology and Anthropology in Honour of Nels Anderson
No full textYamane Hiroko. Caldarola (Carlo) Christianity: the Japanese Way. Monographs and Theorical Studies in Sociology and Anthropology in Honour of Nels Anderson. In: Archives de sciences sociales des religions, n°49/2, 1980. p. 243
Borghi in Festival: Belforte del Chienti, Caldarola, Camporotondo di Fiastrone, Cessapalombo, Serrapetrona (prov. Macerata)
No full textL'idea progettuale nasce dalla volontà di valorizzare i cinque comuni (Belforte del Chienti, Caldarola, Camporotondo di Fiastrone, Cessapalombo, Serrapetrona) della prima dorsale appenninica in provincia di Macerata e il territorio che li comprende. Attraverso “tour virtuali” riproposti in cinque distinti appuntamenti dislocati uno in ogni comune nel periodo estivo, si prevede di presentare un comprensorio nelle sue peculiarità e nelle sue eccellenze. Le diverse proposte saranno realizzate in collaborazione con le associazioni locali e alcuni cittadini che si contraddistinguono per vivacità culturale. ll format sarà simile in tutte e cinque le località in cui si promuoveranno convegni e mostre per far emergere informazioni e presentazioni di percorsi naturalistici e culturali, rivolti sia ad un pubblico di locali che a un pubblico di turisti provenienti da territori limitrofi o da fuori regione, al fine di veicolarne la conoscenza e la capacità attrattiva
Budget impact analysis of PCSK9 inhibitors costs from a community payers' perspective in Apulia, Italy
No full textIntroduction: Despite established clinical efficacy of PCSK9 inhibitors (PCSK9i) in reducing cardiovascular events, their cost still represents a big matter of debate. We therefore sought to estimate possible impact of PCSK9i therapy from a community taxpayers' perspective with a budget impact analysis based on data coming from two randomised trials (FOURIER (Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk), ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab)). Methods: The analysis focused on Apulia region, South-Eastern Italy (4 million inhabitants). Costs per cardiovascular event saved were calculated from randomised trials data and annually indexed per Apulia's inhabitants. Results: On the base of actual cost in Apulia, individual costs per saved adverse event ranged from €0.12 to €0.78, with just €1 annually spent per Apulia's inhabitant, 2-8.3 events could be avoided thanks to the use of PCSK9i. When considering high-risk subgroups (baseline cholesterol levels >100 mg/dL, multivessel coronary disease), the annual cost per Apulia's inhabitant for one death avoided was more than halved to €0.19 and the cost for a saved major adverse cardiovascular event was €0.07. With €1 annually spent per Apulia's inhabitant, 10.9-15 major adverse cardiovascular events and 5.3 deaths could be saved. Conclusions: When considered from a large taxpayers' community perspective, relevant costs per cardiovascular event saved with PCSK9i may turn into very small individual costs per year. The selection of high-risk subgroups may further reduce individual costs
2019 ESC Guidelines on diabetes, pre-diabetes and cardiovascular diseases: what's new? The cardiologist's point of view
No full textIvabradine, coronary artery disease, and heart failure: beyond rhythm control
No full textPietro Scicchitano,1 Francesca Cortese,1 Gabriella Ricci,1 Santa Carbonara,1 Michele Moncelli,1 Massimo Iacoviello,1 Annagrazia Cecere,1 Michele Gesualdo,1 Annapaola Zito,1 Pasquale Caldarola,2 Domenico Scrutinio,3 Rocco Lagioia,3 Graziano Riccioni,4 Marco Matteo Ciccone1 1Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy; 2Section of Cardiovascular Diseases, Policlinic, San Paolo Hospital, Bari, Italy; 3Section of Cardiovascular Diseases, Fondazione Maugeri, Cassano Murge, Italy; 4Intensive Cardiology Care Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy Abstract: Elevated heart rate could negatively influence cardiovascular risk in the general population. It can induce and promote the atherosclerotic process by means of several mechanisms involving endothelial shear stress and biochemical activities. Furthermore, elevated heart rate can directly increase heart ischemic conditions because of its skill in unbalancing demand/supply of oxygen and decreasing the diastolic period. Thus, many pharmacological treatments have been proposed in order to reduce heart rate and ameliorate the cardiovascular risk profile of individuals, especially those suffering from coronary artery diseases (CAD) and chronic heart failure (CHF). Ivabradine is the first pure heart rate reductive drug approved and currently used in humans, created in order to selectively reduce sinus node function and to overcome the many side effects of similar pharmacological tools (ie, β-blockers or calcium channel antagonists). The aim of our review is to evaluate the role and the safety of this molecule on CAD and CHF therapeutic strategies. Keywords: chronic heart failure, heart rate reduction, cardiac ischemic disease, heart-rate lowering drugs, funny curren
- …
