1,720,981 research outputs found
Importanza del mappaggio genetico fine per la definizione farmacogenomica : esempio dell'ACE e risposta a LOSARTAN
No full textRAZIONALE. L'allele D del gene ACE è associato a maggior rischio cardio-renale. I dati sono controversi per la risposta alla terapia antiipertensiva.
Abbiamo eseguito uno studio farmacogenomico tra locus ACE e risposta a Losartan in ipertesi naïve (EH), mai trattati prima, per evitare ogni effetto carry-over.
CASISTICA E METODI. Analisi della struttura di linkage disequilibrium (LD) di ACE per individuare SNPs tagging I/D, su 1013 soggetti etnicamente omogenei, caratterizzati anche per I/D. Gli SNP rs4341, rs4342, rs1987692 sono in LD assoluto con I/D, quindi tag.
Farmacogenomica: 388 EH caucasici, genotipizzati con ILLUMINA 1MDuo. Imputazione con aplotipi CEU 1000Genomes.
Fenotipo: caduta pressoria sistolica dopo 4 settimane di terapia con Losartan (ΔSBP), analizzata con regressione lineare, modello additivo, correggendo per età, sesso ed etnia.
RISULTATI. I tre tag SNP sono significativamente associati a ΔSBP (p=3x10). Estendendo l'analisi a tutto il locus (400 kbp), abbiamo analizzato 110 SNP, notando un progressivo aumento di significatività
alla regione flanking-3’ del gene (rs4461142, p=5.86x10
-2
) a
circa 2.000 bp dal codone di stop di ACE, associato a una caduta
pressoria di 3.7 mmHg nei CC rispetto ai portatori dell’allele T. Il polimorfismo
è solo in debole LD con I/D (r
=0.6).
A conferma della specificità per Losartan, ripetendo lo stesso espe-
2
rimento in 180 EH trattati con placebo e 660 con idroclorotiazide,
-3
non è stato osservato nessun effetto attribuibile al genotipo (p=0.84
e p=0.97).
CONCLUSIONI. Nonostante siano passati più di 20 anni dalla prima
segnalazione, è probabile che il polimorfismo I/D non abbia un ruolo
funzionale ma che sia solo un proxy di altri non ancora identificati.
Questo studio di mappaggio fine punta alla regione flanking-3’ che
potrebbe essere connessa a un sito regolatore per il gene ACE, localizzata
a circa 6.000 bp dallo pseudogene
ACE3p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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