1,721,761 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
TESI DI DOTTORATO:Gefitinib and Radiotherapy in patients with locally advanced inoperable squamous cell carcinoma of the head and neck. CANDIDATO: C.Romano. RELATORE: S.Pepe.
No full textIntroduction: Gefitinib, an orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces growth arrest in squamous cancer cell carcinoma of head and neck (SCCHN) cell lines mainly by blocking cells in G1 and preventing them from entering the cell cycle. Clinical studies have demonstrated the activity of gefitinib monotherapy in SCCHN. Preclinical studies
have shown that the combination of radiotherapy (RT) and drugs interfering with the EGF pathway may result in radiosensitization in squamous cell carcinomas that over express EGFR.
Purpose: Two different doses of gefitinib, administered along with standard radiation therapy, were tested in locally advanced inoperable head and neck cancer who have neiver received radiotherapy or chemotherapy or undergone surgery for head and neck carcinoma, with the aim of finding the maximum
tolerated dose and assessing the toxicity and activity of the combination.
Patients and methods: The standard “3+3” design was used for the phase I study. Radiation therapy was given according to conventional dose and schedule. Gefitinib dose escalation was stopped if more than a third of patients of a given cohort had dose limiting toxicity (DLT).
Results: DLT was observed in 3 out of 4 patients treated at the dose of 500 mg and included grade 3 stomatitis in 3 patients and grade 3 liver toxicities in 1 patient. The dose level of 250 mg was recommended for the phase II study. Six confirmed objective responses were observed among 16 patients. Four patients
had a complete response, which was confirmed in three cases; eight patients had a partial response, which was not confirmed in six patients. Stable disease and disease progression were observed in one and three patients, respectively. Median
duration of response was 5.4 (range: 1–21) months. The observed stable disease lasted 7.4 months. The median progression free-survival was 6.7 months (95% CI: 4.5–12.1) and the median OS was 8.5 months.
Conclusion: Our results do not support further trials with gefitinib and radiation therapy, according to our schedule, in this patient population. Integration of gefitinib within chemoradiotherapy regimens and combination with other biological therapies may represent the next challenge
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
HLA-DQ and celiac disease: a novel risk gradient for predisposed subjects
Full text linkBACKGROUND. Celiac disease (CeD) is an immune-mediated systemic disorder elicited by gliadin, a prolamine found in wheat and related proteins, occurring in genetically predisposed individuals, carrying HLA-DQ2 and/or DQ8. Several heterodimers have been associated with CeD: the HLA-DQ2.5, occurring in approximately 90% of CeD patients, is encoded by the DQB1*02 and DQA1*05 alleles both in cis and in trans; the HLA-DQ2.2 heterodimer, encoded by the DQB1*02 and DQA1*02 allele; and the HLA- DQ8 heterodimer, encoded by the DQB1*03:02 and DQA1*03 alleles. AIMS. We aimed: 1) To characterize HLA polymorphisms; 2) to confirm the association between HLA class II genes with CeD; 3) to assess their role in CeD genetic susceptibility by re-defining the current risk pyramid of genetically predisposed individuals. METHODS. We included celiac children diagnosed based on European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) criteria and controls. The control group included healthy Italian individuals and affected family-based controls (AF-BAC). All individuals were typed for DRB1, DQA1, and DQB1 genes by sequence-specific primer–polymerase chain reaction (SSP-PCR). Disease risks are expressed as 1:N, where N is the number of individuals among which one patient is present. Considering a disease prevalence of 1:100 in the general population, for each HLA-DQ category, N is calculated as a percentage of controls with that particular HLA-DQ status multiplied by 100 and divided by percentage of patients with the same DQ typing. RESULTS: We included 778 CeD patients (M:277= F:511), and 551 controls (292 healthy Italian individuals and 259 affected family-based controls). In conclusion, the new risk pyramid shows an increased risk for all haplotypes; it is reasonable to assert that there is an increased CeD risk in presence of DQ*B102 either as a single copy or combination with other alleles
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
The synchronisation of working times in dual earner couples: an Optimal Matching application
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