1,720,982 research outputs found
Nutraceuticals in Paediatric Patients with Dyslipidaemia
No full textCoronary heart disease (CHD) is the main cause of death and morbidity in the world.
Childhood is a critical period during which atherosclerosis may begin to develop; in the presence
of familial hypercholesterolaemia (FH), the lifelong elevation of LDL cholesterol levels greatly accelerates
atherosclerosis. Lowering LDL-C levels is associated with a well-documented reduction
in cardiovascular disease risk. Current guidelines support the dietary and lifestyle approach as the
primary strategy of intervention in children and adolescents with FH. Nutraceuticals (functional
foods or dietary supplements of plant or microbial origin) are included in the EU guidelines as
lifestyle interventions and may provide an additional contribution in reducing LDL levels when
pharmacological therapy is not yet indicated. Meta-analyses of randomised clinical trials have demonstrated
that the same nutraceuticals improve lipid profile, including lowering LDL-C, total cholesterol
and triglyceride levels. In this narrative review, starting from current scientific evidence, we analyse
the benefits and limitations of the nutraceuticals in children and adolescents with dyslipidaemia, and
we try to evaluate their use and safety in clinical practice
Statin therapy versus cholestyramine therapy in a population of italian children with familial hypercholesterolemia : effect on blood lipid profile
No full textOmocisteina plasmatica e genotipo MTHFR in una popolazione di bambini con ipercolesterolemia familiare eterozigote
No full textLivelli aumentati di omocisteina plasmatica sono un fattore di rischio indipendente per patologia cardiovascolare (CVD) in età adulta. L'obiettivo di questo studio è la valutazione dei livelli di tHcy e la correlazione con genotipo MTHFR in una popolazione di bambini con ipercolesterolemia familiare (FH) al primo accesso presso il nostro Centro di Dislipidemie Pediatriche. [...] Conclusioni: nella popolazione di bambini FH abbiamo riscontrato livelli di tHcy sempre nella norma; tali valori aumentano durante la fase puberale, in particolare nei soggetti TT. L'analisi genetica consente dunque di individuare precocemente quei soggetti che, in assenza di supplementazione vitaminica specifica (vitamina B12 e acido folico), svilupperanno iperomocisteinemia moderata in etá adulta
Plasma homocysteine distribution and its association with parental history of cardiovascular disease in a population of children with heterozygous familial hypercholesterolemia
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Lipoprotein(a) levels in a population of Italian children with familial hypercholesterolemia (FH)
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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