1,662 research outputs found
L-DOPA synthesis in Mucuna pruriens (L.) DC. is regulated by polyphenol oxidase and not CYP 450/tyrosine hydroxylase: An analysis of metabolic pathway using biochemical and molecular markers
No full textSaranya, G., Jiby, M.V., Jayakumar, K.S., Pillai, P. Padmesh, Jayabaskaran, C. (2020): L-DOPA synthesis in Mucuna pruriens (L.) DC. is regulated by polyphenol oxidase and not CYP 450/tyrosine hydroxylase: An analysis of metabolic pathway using biochemical and molecular markers. Phytochemistry (112467) 178: 1-10, DOI: 10.1016/j.phytochem.2020.112467, URL: http://dx.doi.org/10.1016/j.phytochem.2020.11246
Potassium retention in leaf mesophyll as an element of salinity tissue tolerance in halophytes
No full textAvailable online 13 October 2016Abstract not availableWilliam J. Percey, Lana Shabala, Qi Wu, Nana Su, Michael C. Breadmore, Rosanne M. Guijt, Jayakumar Bose, Sergey Shabal
Antibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer
No full textDysregulated expression and/or mutations of the various components of the phosphoinositide 3-kinase (PI3K)/Akt pathway occur with high frequency in prostate cancer and are associated with the development and progression of castration resistant tumors. However, small molecule kinase inhibitors that target this signaling pathway have limited efficacy in inhibiting tumor growth, primarily due to compensatory survival signals through receptor tyrosine kinases (RTKs). Although members of the epidermal growth factor receptor (EGFR), or HER, family of RTKs are strongly implicated in the development and progression of prostate cancer, targeting individual members of this family such as EGFR or HER2 has resulted in limited success in clinical trials. Multiple studies indicate a critical role for HER3 in the development of resistance against both HER-targeted therapies and PI3K/Akt pathway inhibitors. In this study, we found that the growth inhibitory effect of GDC-0941, a class I PI3K inhibitor, is markedly reduced in the presence of heregulin. Interestingly, this effect is more pronounced in cells lacking phosphatase and tensin homolog function. Heregulin-mediated resistance to GDC-0941 is associated with reactivation of Akt downstream of HER3 phosphorylation. Importantly, combined blockade of HER2 and HER3 signaling by an anti-HER2/HER3 bispecific antibody or a mixture of anti-HER2 and anti-HER3 antibodies restores sensitivity to GDC-0941 in heregulin-treated androgen-dependent and -independent prostate cancer cells. These studies indicate that the combination of PI3K inhibitors with HER2/HER3 targeting antibodies may constitute a promising therapeutic strategy for prostate cancer.</p
Increased urine semaphorin-3A is associated with renal damage in hypertensive patients with chronic kidney disease: a nested case-control study
No full textGaAs/AlGaAs heterostructure based micro-hall sensors and response to A.C. excitation
No full textHall sensors are fabricated from GaAs/AlGaAs based heterostructures. The sensors are characterized for sensitivity using A.C and D.C. excitation techniques w.r.to a known magnetic field in the range of 0-100Oe. Sensitivities of the order of 1000V/AT are obtained with a low variation of 0.15% in the temperature range of 30°C-100°C. A.C excitation (30Hz to 1 kHz) for the sensor current and phase-sensitive detection of the Hall Voltage are used to eliminate thermo-emfs and its drift with a consequent improvement in data acquisition rates of >50% over that of D.C excitation. This improves scan rates in applications such as magnetic flux leakage (MFL) measurements. The sensitivity is independent of the frequency of excitation as expected; however, the zero-field Hall voltage 'offset' value is found to have small frequency dependence.</p
Pompano farming at Vethalai using low-cost cages: Technology demonstration initiative by Mandapam RC
No full textAn artisanal type of cage was fabricated at Mandapam Regional
Centre with 6×6 m outer and 5×5 m inner square frame,
which is made of 50mm GI pipe for farming demonstrations involving
local fishermen at Vethalai village, Ramnad District, Tamil Nadu.The ongoing pompano farming
demonstration in an artisanal type of sea cages is a way forward for
the spread of mariculture in India.
(Reported by G. Gopakumar,
A. K. Abdul Nazar, R. Jayakumar, G. Tamilmani,
M. Sakthivel, C. Kalidas, P. Ramesh Kumar &
Johnson B., Mandapam Regional Centre
Artisanal innovation in cage farming of pompano at Vethalai, Ramanathapuram
No full textOn 25th July 2012, pompano from an artisanal cage was
harvested. The total harvest was 92 kg, the length and weight
ranges observed were 16 to 32 cm and 62 to 433 grams.The harvest was handed over to the farmer Shri.Nagadoss
by Dr. G. Gopakumar, Scientist-in-Charge. The farm gate price
for the harvested pompano was `120/kg- and it was sold by
the merchant in the retail market at `180/kg-.
Reported by G.Gopakumar, A. K. Abdul Nazar,
R. Jayakumar, G. Tamilmani, M. Sakthivel, C. Kalidas,
P. Ramesh Kumar & Johnson B., Mandapam Regional Centr
Fig. 5 in L-DOPA synthesis in Mucuna pruriens (L.) DC. is regulated by polyphenol oxidase and not CYP 450/tyrosine hydroxylase: An analysis of metabolic pathway using biochemical and molecular markers
No full textFig. 5. The amplicons generated using degenerate primer approach. (a) Lane M-DNA ladder, Lane 1–250 bp amplicon generated using MTH –F and MTH-R primer pairs of TH gene (b) Lane M-DNA ladder, Lane 1 and 2–800 bp amplicon using primers deduced from the peptide sequence derived through LCMS/MS.Published as part of Saranya, G., Jiby, M.V., Jayakumar, K.S., Pillai, P. Padmesh & Jayabaskaran, C., 2020, L-DOPA synthesis in Mucuna pruriens (L.) DC. is regulated by polyphenol oxidase and not CYP 450/tyrosine hydroxylase: An analysis of metabolic pathway using biochemical and molecular markers, pp. 1-10 in Phytochemistry (112467) 178 on page 5, DOI: 10.1016/j.phytochem.2020.112467, http://zenodo.org/record/829298
Correction: One-step coelectrodeposition-assisted layer-by-layer assembly of gold nanoparticles and reduced graphene oxide and its self-healing three-dimensional nanohybrid for an ultrasensitive DNA sensor
No full textCorrection for ‘One-step coelectrodeposition-assisted layer-by-layer assembly of gold nanoparticles and reduced graphene oxide and its self-healing three-dimensional nanohybrid for an ultrasensitive DNA sensor’ by Jayakumar Kumarasamy, et al., Nanoscale, 2018, DOI: 10.1039/c7nr06952a. The names of two of the co-authors are given incorrectly in the published article. “Jayakumar Kumarasamy� should instead be listed as “Kumarasamy Jayakumar�, and “Dharuman Venkatraman� should instead be listed as “Venkataraman Dharuman� as shown in the corrected author list above. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers
Scientists monitor cobia demonstration farm at Rajulalanka, AP
No full textDr.A.K.Abdul Nazar, Senior Scientist
and Dr. R. Jayakumar, Senior
Scientist, Mandapam Regional Center of
CMFRI visited the Cobia demonstration
farm at Rajulalanka, Narasapur, West
Godavari District on 14th June 2012 and
interacted with Mr. Vasu and Mr.
Subbaraju, regarding the mortality
problems encountered during the rearing
of fingerlings of cobia.
(Reported by G.Gopakumar,
A.K.Abdul Nazar, R.Jayakumar,
G.Tamilmani, M.Sakthivel, C.Kalidas,
P.Ramesh Kumar & Johnson, B.
Mandapam Regional Centre
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