1,550 research outputs found
Comments on “A proportional-integral extremum-seeking controller design technique” [Automatica 77 (2017) 61–67]
No full textIn the proof of [Guay and Dochain (2017), Th.1], Equation 6 is incorrect.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Sergio GrammaticoTeam Bart De Schutte
Role of tRNA fragments in islet macrophage activation and in the crosstalk with β-cells during obesity
No full textIslet-resident macrophages (Mφs) play a key role in pancreatic islet homeostasis but their activation in obesity results in β-cell dysfunction. This activation is likely to be elicited by modulatory molecules highly sensitive to environmental changes. The pool of transfer RNAs (tRNAs) is strictly regulated by nutrient availability and under stress conditions tRNAs can be cleaved, generating fragments (tRFs) with regulatory functions. Moreover, tRFs play a crucial role in extracellular vesicles (EVs)-mediated cell-to-cell crosstalk. The aim of the present work was to determine the impact of obesity on the tRF profile of islet Mφs and to investigate the role of these RNAs in Mφ activation and in the crosstalk with β-cells.
Islet Mφs and β-cells were isolated from obese db/db and lean wild type mice. Small RNA sequencing identified 15 modulated tRFs (≥1.5-fold change, p≤0.05, n=4) in db/db islet Mφs. To assess their role in Mφ activation, we compared the tRF profile of db/db islet Mφs to that of bone marrow derived Mφs (BMDMs), polarized into M1 pro- and M2 anti-inflammatory Mφs. Interestingly, 7 of the tRFs upregulated in db/db islet Mφs were enriched in M2 BMDMs (≥1.5-fold change, p≤0.05, n=3). Inhibition of one of these fragments, 5’tRFGlu(CTC), led to profound transcriptomic changes in both M1 and M2 BMDMs (n=3), with a preferential impact on genes involved in T-cell stimulation and in acute immune responses. Among the tRFs upregulated in obese islet Mφs, 5’tRFGlu(CTC), 5’tRFGly(GCC) and 5’tRFAsp(GTC) were also increased in β-cells of db/db mice and were abundant in EVs released by M2 BMDMs, suggesting a possible role in the crosstalk between islet cells.
Our data suggest that tRFs may act as key modulators of Mφs activation and that obesity induces an upregulation of anti-inflammatory tRFs in islet Mφs. RNA labelling and EVs transfer techniques are currently being used to investigate the contribution of tRFs in Mφ-β-cell crosstalk
Transfer RNA fragments induced during obesity hold regulatory functions in islet macrophage activation and beta cell homeostasis
No full textSpatial Analysis of Rural Homelessness Support Services in the West Kootenay Region
No full textNursing & Human Service
Athabasca School District No. 839 (1958-1959)
No full textPhotograph - Teacher Alice B. Donahue and her grade two class at Athabasca Public School, Athabasca, Alberta. Front row: Daryl Goodwin, Howard McLeod, Rick Zelman, ....Budney, unknown, unknown, Brenda Guay, Pat Mackie, Tim King, Alice Kobzey. Middle row: ....Todd, Lyle ..., Frank McCullough, Janice Locker, Gordon Lines, unknown, Linda Harper, unknown, Paul Gustafson, Vernon ...Back row: unknown, Lorna Jewell, Leon Guay, John McLevin, Carol McKelvey, Gordon Loiselle, Kathy Kaplun, unknown, unknow
Physicochemical characterization of mixed RuO2-SnO2 solid solutions
No full textMixed SnO2-RuO2 oxides were prepared by high-energy mechanical alloying of various proportions of pure SnO2 and RuO2 powders. The physicochemical characterization of the resulting materials was conducted by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and electrochemical surface analysis. It is shown through XRD analysis that a single-phase (tetragonal) (Sn-Ru)O-2 solid solution is formed over the whole composition range, in which the Sn4+ and Ru4+ ions share the same cationic sub-lattice of the rutile-like structure. The surface of the compounds was analyzed by XPS and shows a deficit of Ru atoms, with [Ru](surface) = 36 at. % for an equimolar SnO2-RuO2 concentration in the bulk of the sample. In the case of pure nanocrystalline RuO2, the total surface charge, q(T)*, the most easily accessible surface charge, q(o)*, and the less easily accessible surface charge, q(1)*, are 35.3, 29.0, and 6.3 mC cm(-2) mg(-1), respectively. These surface charges vary linearly with the Ru content at the surface of the electrode, indicating that the surface electrochemical properties of the compounds are dominated by the redox properties of the Ru4+ cation. The ratio q(o)*/q(T)* is close to 0.8 and independent of the surface composition, suggesting that all compounds have a similar morphology
CPX, a selective A1-adenosine-receptor antagonist, regulates intracellular pH in cystic fibrosis cells
No full textPHYTOSANITARY REGULATION AND AGRICULTURAL FLOWS: TOBACCO INPUTS AND CIGARETTES OUTPUTS
No full textThis paper examines the effects of the use of increasingly-popular phytosanitary regulations on production costs, and output and factor trade flows. The case addressed is that of the European regulation of maximum chemical residues in cigarettes manufactured with tobacco containing maleic hydrazide. The paper presents simulations of the effects of tightening the input/output market linkages and on the substitution away from the residue-contaminated U.S. input to residue-free non-U.S. inputs. This induced substitution results in higher costs, lower quantity supplied of the final product, and higher prices for U.S. cigarettes in Europe. Cross-price effects lead to higher quantities of EU cigarettes sold and a corresponding increase in the use of all inputs, including U.S. tobacco. When the U.S. tobacco price is allowed to fall, direct price effects stimulate the EU derived demand for U.S. tobacco. Although the regulation is protectionist in the output market, it leads to increased EU imports of the residue-contaminated input. When the price of U.S. tobacco adjusts, the regulation is actually antiprotective for EU growers. The regulation also indirectly influences production practices of U.S. tobacco growers and leads to lower levels of MH residues on U.S. leaf.Agricultural and Food Policy,
Conceptual Foundations of Yang–Mills Theories
No full textEssay review of Gauging What’s Real: The Conceptual Foundations of Contemporary Gauge Theories R. Healey. Oxford University Press (2007). To be published in the Studies in History and Philosophy of Modern Physics, 39(3):687-693, 2008
Johnny Guay and Art Schultz
No full textPhotograph - Two men standing in front of Baptiste Lake Supplies Store, Baptiste Lake, Albert
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