891 research outputs found
Turnbull C., L'Africain désemparé.
No full textBonvin F. Turnbull C., L'Africain désemparé.. In: Revue française de sociologie, 1967, 8-1. pp. 111-112
Webinar #1 - Integrative Modelling with HADDOCK 2.2
No full textThe prediction of the quaternary structure of biomolecular macromolecules is of paramount importance for fundamental understanding of cellular processes and drug design. In the era of integrative structural biology, one way of increasing the accuracy of modelling methods used to predict the structure of biomolecular complexes is to include as much experimental or predictive information as possible in the process.
We have developed for this purpose a versatile information-driven docking approach HADDOCK (http://www.bonvinlab.org/software/haddock2.2) [1-3]. HADDOCK can integrate information derived from biochemical, biophysical or bioinformatics methods to enhance sampling, scoring, or both [4]. The information that can be integrated is quite diverse: interface restraints from NMR, mutagenesis experiments, or bioinformatics predictions; shape data from small-angle X-ray scattering [5] and, recently, cryo-electron microscopy experiments [6].
References
G.C.P van Zundert, J.P.G.L.M. Rodrigues, M. Trellet, C. Schmitz, P.L. Kastritis, E. Karaca, A.S.J. Melquiond, M. van Dijk, S.J. de Vries and A.M.J.J. Bonvin. The HADDOCK2.2 webserver: User-friendly integrative modeling of biomolecular complexes. J. Mol. Biol., 428, 720-725 (2015).
S.J. de Vries, M. van Dijk and A.M.J.J. Bonvin The HADDOCK web server for data-driven biomolecular docking. Nature Protocols, 5, 883-897 (2010).
C. Dominguez, R. Boelens and A.M.J.J. Bonvin HADDOCK: A protein-protein docking approach based on biochemical or biophysical information. J. Am. Chem. Soc., 125, 1731-1737 (2003).
J.P.G.L.M Rodrigues and A.M.J.J. Bonvin Integrative computational modeling of protein interactions. FEBS J., 281, 1988-2003 (2014).
E. Karaca and A.M.J.J. Bonvin. On the usefulness of Ion Mobility Mass Spectrometry and SAXS data in scoring docking decoys. Acta Cryst. D., D69, 683-694 (2013).
G.C.P. van Zundert, A.S.J. Melquiond and A.M.J.J. Bonvin. Integrative modeling of biomolecular complexes: HADDOCKing with Cryo-EM data. Structure. 23, 949-960 (2015).”
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Investissement social
No full textDahmen S, Bonvin J-M. Investissement social. In: Bonvin J-M, Hugentobler V, Knoepfel C, Maeder P, Tecklenburg U, eds. Dictionnaire de politique sociale suisse. Seismo Verlag AG; 2020
The Swiss Welfare State System: With Special Reference to Education Policy
No full textDahmen S, Bonvin J-M. The Swiss Welfare State System: With Special Reference to Education Policy. In: Aspalter C, ed. The Routledge International Handbook to Welfare State Systems. Routledge international handbooks. London ; New York: Routledge; 2017: 274-290
The orientations of cytochrome c in the highly dynamic complex with cytochrome b5 visualized by NMR and docking using HADDOCK
No full textThe interaction of bovine microsomal ferricytochrome b5 with yeast iso-1-ferri and ferrocytochrome c has been investigated using heteronuclear NMR techniques. Chemical-shift perturbations for 1H and 15N nuclei of both cytochromes, arising from the interactions with the unlabeled partner proteins, were used for mapping the interacting surfaces on both proteins. The similarity of the binding shifts observed for oxidized and reduced cytochrome c indicates that the complex formation is not influenced by the oxidation state of the cytochrome c. Protein-protein docking simulations have been performed for the binary cytochrome b5-cytochrome c and ternary (cytochrome b5)-(cytochrome c)2 complexes using a novel HADDOCK approach. The docking procedure, which makes use of the experimental data to drive the docking, identified a range of orientations assumed by the proteins in the complex. It is demonstrated that cytochrome c uses a confined surface patch for interaction with a much more extensive surface area of cytochrome b5. Taken together, the experimental data suggest the presence of a dynamic ensemble of conformations assumed by the proteins in the complex
Situation awareness via information hovering in post-disaster communications
No full textThe majority of communication solutions for post-disaster areas rely on cellular infrastructure support. But disasters such as fires, floods, earthquakes, can disrupt communication network making its services unavailable. New portable antenna towers, as point-to-point radio communications, are a way to mitigate the communication when cellular infrastructures are unavailable. But their deployment requires time decreasing the likelihood of finding people alive in the following of such events. In this work, we present the architecture of Floater, a mobile application that implements opportunistic communication for context-aware services in post-disaster scenarios. Floater is based on Floating Content, an opportunistic communications paradigm that geographically constrains message replication. We implement Floater using Google Nearby API that enables seamless nearby interactions without having to be connected to the Internet. Moreover, we provide the implementation notes and the comparison of the technologies adapted with the respect of the state-of-the-art
Floater: Post-disaster Communications via Floating Content
No full textIn the immediate aftermath of nature-based disasters such as earthquakes, fires, or floods, have a clear vision of the situation and the population involved is of main priority for rescue operations—it is a matter of life and death. But these disaster events may cause malfunctions in communication services making the exchange information impossible—the experienced delay sending a message in an overcrowded area is a shred of evidence. In this demo, we introduce Floater, a mobile awareness-based communication application for the immediate aftermath of a disaster, when ad hoc infrastructure support has not been deployed yet. Floater enables communications between peers in a common area without requiring the support of a cellular network. The application is developed for Android and it does not require an account or an Internet connection. Floater exploits local knowledge and constraints opportunistic replication (peer to peer) of information to build a global view of the involved area efficiently. The app is the first to implement Floating Content, an infrastructure-less communication paradigm based on opportunistic replication of a piece of content in a geographically constrained location and for a limited amount of time. The demo illustrates the feasibility and the main functionalities of Floater and presents disaster assistance use cases for supporting rescue operations
Essai sur les eaux thermales de Loëche / par C. J. Bonvin,... (traduit de l'allemand)
No full textContient une table des matièresAvec mode text
Intimate citizenship and gendered well-being: the claims and interventions of women’s movements in Europe
No full textEuropean social movements improve the well-being of men and women but need further analysis through a gender-sensitive lens. Taking an international and cross-disciplinary perspective, this book examines the impact of European social movements on gendered political and material well-being. Insights from history, politics, sociology and gender studies help identify how social movements have been instrumental in changing individual well-being through participation and empowerment. These movements have contributed to collective well-being thanks to victories in health, sexualities, political recognition and access to material goods.
The contributions pay particular attention to the role of women activists in social movements varying from unions and religious movements to the women's movement itself. The settings range from 19th century Catalonia to Switzerland and Poland, including studies on European transnational movements today and their impact on global gendered well-being. The authors consider how gender has been important in defining the goals, strategies and outcomes of social movements. Thanks to the international spread of contributions a comparative record can be examined. Together the authors provide unique and concrete illustrations of the role of collective action and the participatory process on transforming women and well-being in European societies. The book provides essential insights for students and scholars working on social and women's movements, European well-being and welfare, and transnational action
Estimation technique for offset-free economic MPC based on modifier adaptation
No full textEconomic model predictive control formulations that combine online optimizing control with offset-free methodologies such as modifier adaptation have been proposed recently. These new algorithms are able to achieve asymptotic optimal performance despite the presence of plant-model mismatch. However, there is a major requirement stemming from the modifier-adaptation part, namely, the necessity to know the static plant gradients at the sought (and therefore still unknown) steady-state operating point. Hence, for implementation purposes, the algorithms need to be enhanced with plant gradient estimation techniques. This work proposes to estimate modifiers directly, based on steady-state perturbations and using Broyden's approximation The proposed economic MPC algorithm has been tested in simulation on the Williams-Otto reactor and provides plant optimality upon convergence. Copyright (C) 2020 The Authors.L
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