55 research outputs found
Module intégré de microbiologie-immunologie I :Les pathogènes et les relations hôtes-pathogènes
No full textSYL-009896 = Volume 1 ;SYL-009895 = Volume 2 ;SYL-009894 = Volume 3 ;SYL-008165 = Volume 4Volume 1 :Les microorganismes et leurs relations avec l'hôte -- Volume 2 :Colonisation et invasion de l'hôte par les microorganismes, mécanismes de pathogénicité et de virulence -- Volume 3 :Modes de transmission des pathogènes à l'hôte et introduction aux stratégies de maîtrise et prévention des infections -- Volume 4 :Modes de transmission des pathogènes à l'hôte et introduction aux stratégies de maîtrise et prévention des infectionsVolume 1 :Carine Truyens avec la participation de M. Struelens, F. Willems, M. Chamekh, C. Liesnard et Y. Carlier ;Volume 2 :Abdelmounaaim Allaoui, avec la participation de M. Chamekh et E. Muraille ;Volume 3 :Marc Struelens, avec la participation de C. Truyens, Y. Carlier, C. Liesnard, F. Jacobs, F. Willems, M. Chamekh et J. Levy ;Volume 4 :Marc Struelens avec la participation de Y. Carlier, M. Chamekh, F. Jacobs, J. Lévy, A. Op De Beeck, C. Truyens, F. WillemsVolume 1 :2006-2007 ;Volume 4 :2007-2008BIME2, VETE2, BMOL-G-205/ VETE-G-208info:eu-repo/semantics/published
Prenatal diagnosis of congenital cytomegalovirus infection: prospective study of 237 pregnancies at risk
No full text
A PCR based DNA hybridisation capture system for the detection of human cytomegalovirus. A comparative study with other identification methods
No full textA simple, sensitive and specific colourimetric hybridisation method for the detection of HCMV DNA in clinical specimens is described. This method combines a PCR assay with a sensitive sandwich hybridisation assay. It relies on the use of a specific capture probe linked covalently to polystyrene microplates and a specific polybiotinylated detection probe. Amplified DNA fragments, sandwiched between these two probes, are detected by an enzymatic colour reaction. This PCR-based colourimetric hybridisation method was compared with other known HCMV detection methods. Clinical specimens (n=145, corresponding to 106 patients) were tested by both a nested PCR assay and this colourimetric hybridisation method; and by either the culture method or the pp65 antigenaemia test depending on the type of sample used. The results showed that the PCR-based hybridisation method has a specificity similar to tissue culture, known as the conventional gold standard method, and could be used for the examination of the clinical specimens. Copyright (C) 1999 Elsevier Science B.V.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Impaired ovarian stimulation during in vitro fertilization in women who are seropositive for hepatitis C virus and seronegative for human immunodeficiency virus
No full textObjective: To analyze the impact of seropositivity with hepatitis C virus (HCV) on in vitro fertilization (IVF) outcomes. Design: Retrospective, case-controlled study. Setting: Fertility clinic of academic hospital. Patient(s): 42 IVF/intracytoplasmic sperm injection cycles in HCV-seropositive women and 84 matched control cycles. Intervention(s): IVF/intracytoplasmic sperm injection treatment for infertility. Main Outcome Measure(s): Ovarian response to stimulation, laboratory findings, and implantation and pregnancy rates. Result(s): Absence of ovarian response was statistically significantly higher for HCV-seropositive women compared with controls (10/42 vs 5/84 cycles, respectively). For cycles with oocyte retrieval, HCV-seropositive women required more gonadotropin units compared with controls. The maximum estradiol levels and number of collected oocytes were similar, but HCV-seropositive women had statistically significantly fewer embryos available compared with controls. Embryo morphologic features, number of transferred embryos, and rates of implantation and pregnancy were similar for HCV-seropositive women and controls. Conclusion(s): When compared with matched uninfected controls, HCV-seropositive women display a decreased ovarian response. © 2007 American Society for Reproductive Medicine.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
High HIV prevalence among patients choosing anonymous and free testing in Belgium, 1990-2002
No full textSCOPUS: ar.jinfo:eu-repo/semantics/publishe
Common Genetic Variation and the Control of HIV-1 in Humans
No full textTo extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians
The course and outcome of unilateral intracranial arteriopathy in 79 children with ischaemic stroke
No full textArteriopathies are the commonest cause of arterial ischaemic stroke (AIS) in children. Repeated vascular imaging in children with AIS demonstrated the existence of a 'transient cerebral arteriopathy' (TCA), characterized by lenticulostriate infarction due to non-progressive unilateral arterial disease affecting the supraclinoid internal carotid artery and its proximal branches. To further characterize the course of childhood arteriopathies, and to differentiate TCA from progressive arterial disease, we studied the long-term evolution of unilateral anterior circulation arteriopathy, and explored predictors of stroke outcome and recurrence. From three consecutive cohorts in London, Paris and Utrecht, we reviewed radiological studies and clinical charts of 79 previously healthy children with anterior circulation AIS and unilateral intracranial arteriopathy of the internal carotid bifurcation, who underwent repeated vascular imaging. The long-term evolution of arteriopathy was classified as progressive or TCA. Clinical and imaging characteristics were compared between both groups. Logistic regression modelling was used to determine possible predictors of the course of arteriopathy, functional outcome and recurrence. After a median follow-up of 1.4 years, 5 of 79 children (6%) had progressive arteriopathy, with increasing unilateral disease or bilateral involvement. In the others (94%), the course of arteriopathy was classified as TCA. In 23% of TCA patients, follow-up vascular imaging showed complete normalization, the remaining 77% had residual arterial abnormalities, with improvement in 45% and stabilization in 32%. Stroke was preceded by chickenpox in 44% of TCA patients, and in none of the patients with progressive arteriopathies. Most infarcts were localized in the basal ganglia. In 14 (19%) of TCA patients, transient worsening of the arterial lesion was demonstrated before the arteriopathy stabilized or improved. Thirteen TCA patients (18%) had a recurrent stroke or TIA. Thirty TCA patients (41%) had a good neurological outcome, compared with none of the five patients with progressive arteriopathy. Arterial occlusion, moyamoya vessels and ACA involvement were more frequent in progressive arteriopathies. Cortical infarct localization was significantly associated with poor neurological outcome (OR 6.14, 95% CI 1.29-29.22, P = 0.02), while there was a trend for occlusive arterial disease to predict poor outcome (OR 3.00, 95% CI 0.98-9.23, P = 0.06). Progressive arteriopathy was associated with recurrence (OR 18.77, 95%CI 1.94-181.97, P = 0.01). The majority of childhood unilateral intracranial anterior circulation arteriopathies (94%) have a course that is consistent with TCA, in which transient worsening is common. Although the arterial inflammation probably causing TCA is 'transient', most children are left with permanent arterial abnormalities and residual neurological deficit
Assistance médicale à la procréation et désir d'enfant de couples infectés par le VIH: Le temps d'un changement d'attitude est-il venu?
No full textToday, in developed countries, many HIV-infected people remain in good health thanks to antiviral medication. A growing number of them want to have children. Medical possibilities for preventing contamination of the partners of seropositive men through assisted reproduction and of children thanks to antiviral medicines during pregnancy are summarized. These changes result in ethical considerations which lead the authors to question the conventional systematic medical advise against pregnancy and has encouraged them to assist reproduction for a number of these couples. Today, the balance between the importance of the message of prevention and the benefit for patients of being assisted in their desire for a child has tilted towards medical intervention. It would seem legitimate today to intervene in the most favourable situations rather than see these couples take the risk of spontaneous conception outside health care structures. This implies to adapt medical structure (separate laboratory, appropriate procedure, precise protocols). This approach, which is coherent from the scientific point of view, respects both the autonomy of people carrying HIV as well as the essential interest for the child, in "being" born uninfected and also has the enormous advantage of allowing access to parenthood without destroying the consistency of the message of prevention of sexual contamination.SCOPUS: re.jinfo:eu-repo/semantics/publishe
Design of a high security ART-Laboratory for hepatitis B, C and HIV-positive patients
No full textinfo:eu-repo/semantics/publishedConférence donnée à Vienne en Juillet 200
- …
