90,586 research outputs found
The ethics of thinking in Heidegger, Bruno & Spinoza
No full textThe aim of the present work is to face Heidegger’s claim that philosophy has ended.
Facing this claim for us has not taken the form of creating a new method or positing a
new question but that of a search for anomalies in what Heidegger decrees as
finished, which is philosophy as metaphysics. In his historical confrontation with the
history of thought Heidegger seems to have left out, dismissed or forgotten those
authors who do not fit into his definition of metaphysics. We have chosen Giordano
Bruno and Baruch Spinoza, metaphysical thinkers who have undertaken a
philosophical practice that does not intend to demolish subjectivity but actually
begins without any need for it. The birth of the subject as grounding reality finds its
affirmation with Descartes and inaugurates modernity that, according to Heidegger,
exhausts philosophy and leads it into the arms of modern science and technology.
Bruno and Spinoza respectively precede and follow the birth of modernity and of
modern science, which they look at with an eye that is not that of the modern subject.
Following their different approaches to philosophy, we shall also explore their
relation to Renaissance Humanism, dismissed by Heidegger as a historical reiteration
of the Roman world, perceived as a perversion of the Greek origin of thought. We
shall show how hasty such a dismissal is. Our goal is to show not merely that
Heidegger is wrong but that if Western thinking contains the seeds of its own end, it
also contains the ones of a different understanding of the Western world and its
achievements. The three authors will engage on the grounds of ontology, gnosiology
and ethics and yet we have defined the whole enterprise of this work as an ethics
overall. An ethics of thinking is a practice of thought that wishes to envisage the
possibility for Western man of inhabiting his own world by understanding himself
not as an isolated subject and master of nature but as the place where the unity and
multiplicity of nature come to be thought at the same time
Bruno Moroncini: accrescere la cerchia
No full textl'articolo presenta la complessiva produzione filosofica di Bruno Moroncini, con speciale riferimento ai temi della relazione tra filosofia e psicoanalisi, dello statuto della comunità, dei compiti attuali della filosofia
Talking about design with Bruno Latour: An Interview
No full textInterview with Bruno Latour about design: design indeed is not something you took explicitly into account in your work, up to the moment
the title of the conference you held in Manchester in October 2007 came out – “Is there a cosmopolitically correct
design?” 1 . Beside that we have known about your presence, as keynote speaker, at Networks of Design, the next
Design History Society conference.
We have then thought that probably it is not completely true that you did not take into account design, even if it is
true that design has never came out as an issue in your work. We would like to know what you said at the
Manchester conference and what you are planning to say at Networks of Design and then discuss why “design”
was never explicitly addressed in your wor
Introducing “La fabrique du droit”. A Conversation with Bruno Latour
No full textBruno Latour talks with Paolo Landri about his book on the Conseil d'Etat (La Fabrique du droit). The conversation was held in 2006 at the time of the Italian translation of the book and illustrates the research project and the difficulties the author had in the field. At the same time, it clarifies the trajectories of Bruno Latour's work and theoretical framework of his program of study with respect to sociology, anthropology, and philosophy of law. The conversation helps to understand the open-ended character of Bruno Latour's research and reflection including STS as well as sociological, anthropological and philosophical themes
Bruno Munari. Aria /Terra
No full textConversazione sulla concezione della mostra dedicata a Bruno Munari
In ossequio a una norma il cui senso ci sfugge: scrivere con Bruno Celano
No full textIl titolo di questo articolo è l'incipit di una formula utilizzata da Bruno Celano nella prima nota dei saggi a due mani. Nella sua versione integrale è la seguente: “In ottemperanza a una norma italiana, di cui non comprendiamo appieno il senso, dichiariamo che le sezioni X e Y sono di Bruno Celano e le sezioni W e Z sono di N”. Dato il processo di scrittura altamente dialogico, possiamo facilmente comprendere perché Celano, con garbata irriverenza, obbedisse alla richiesta di attribuire la titolarità di ogni sezione a unautore, non esimendosidall’esprimereun certo dissenso.Nella sua vasta produzione, i testia doppia firmasono pochie recenti. Tuttavia, raccontare la pratica creativa della scrittura congiunta ci permette di mostrare un tratto distintivo dell'intera opera di Bruno Celano, ovvero il pensare e il ricercare in dialogo. Nel presente lavoro, Clelia Bartoli, Marco Brigaglia e Giuseppe Rocché ripercorrono alcuni elementidal backstage del lavoro di Celano, soprattutto negli ultimi anni segnati dalla malattia.The title of this article is the incipit of a formula used by Bruno Celano, to be placed in the first note of the two-handed essays. In its completeversion it is as follows: «In complying with an Italian rule, whose point we do not fully understand, we declare that sections X and Y are by Bruno Celano and sections W and Z are by N». Given the highly dialogic process of writing that took place with Celano, we can easily understand why he,with gentle irreverence,obeyed by disagreeing to attribute ownership of each section to each author.In hisvast production, publications withanother author are few and recent. However, recounting the creative practiceof joint writing allows us to show a distinctive feature of Bruno Celano's entire oeuvre, which was thinking and researching in dialogue. In the current paper, Clelia Bartoli, Marco Brigaglia,and Giuseppe Rocchétrace some aspects of the backstage of Celano's work, especially inthe utmost years marked by illness
c-myb and growth control.
No full textThe available evidence indicates that c-myb plays an important role in the proliferation of hematopoietic cells and in those nonhematopoietic cell types in which c-myb is expressed. A critical aspect in the regulation of c-myb expression rests in the positive autoregulatory mechanism, which is dependent on the interaction of myb protein with the 5' flanking region of the human c-myb gene. The positive autoregulation of c-myb, in conjunction with tissue-specific mechanisms that most likely involve efficient transcription beyond the site of "transcriptional pause" in the c-myb first intron, might allow the generation of c-myb transcripts at levels sufficiently high for optimal biological activity (e.g., at the G1/S transition of the cell cycle). Other transactivating factors, such as the Jun family members, also appear to be involved in regulating c-myb expression. Such factors might act to increase basal levels of c-myb expression to allow activation of the autoregulatory mechanism, or might cooperate with myb in transcriptional regulation of c-myb expression. The function of c-myb is ultimately dependent on the genes that are regulated by the myb product. Preliminary evidence suggests that DNA polymerase-alpha and cdc2, two genes that are critical for DNA synthesis, contain myb binding sites in their promoter region that appear to be required for myb transactivation of their expression. The paradox of the generality of the mechanisms by which c-myb affects cell proliferation and the apparent tissue-specific expression of this gene might be resolved by the growing evidence that the tissue distribution of c-myb is more general than previously appreciated, and that many cell types with no detectable c-myb expression contain a functional equivalent of this gene. For example, B-myb a gene that is homologous to c-myb in the DNA binding and transactivating domains and appears to be ubiquitously expressed, is also required for cell proliferation and, like c-myb, appears to regulate the expression of cdc2, a gene required for cell cycle progression. Together, these findings indicate a general role of members of the myb family in regulation of cell proliferation
Archaeology of the Early medieval Nomads in Italy: the Horse-Burials from South-Central Italy
No full textThe author in this volume edited by C. Balint and hosting the acts of a Symposium held in the Accademia d'Ungheria in November 1993 in Rome entitled Kontakte between Iran, Bysanz und der Steppe im 6.-7. Jahrhundert, is dealing with a special type of burials of the early middle age: the horse graves. Taking the occasion of the symposium the author is dealing with a short history of the main important of such finds in east Europe and in Asia from VII century AD, including the sensational discovery in Italy, in Molise of the first horse graves in Vicenne in a Lombard age cemetery. This find is particularly important because, both for the uniqueness of this type, and basically for the presence of cast iron stirrups of Avarian Age and datable to the 7th century. This date is much earlier than the usual dating of other finding of such objects in Europe, before considered datable back only to the Charles the Great period
Natures muses in Bruno Tuat’s Glashaus
No full textConstructed for the 1914 Werkbund Exhibition in Cologne, Germany, the Glashaus was both a seminal example of early modernist architecture and Bruno Taut’s signature building. Over time, metaphors have come to be applied to the Glashaus. Within the realm of nature these metaphors include cosmic, geological, botanic and sexual. However these metaphors, like the history of the Glashaus, are not a foregone conclusion. Recently it has been argued that the majority of our current knowledge regarding the Glashaus derives not from the perspective of Bruno Taut as the architect, but rather directly from perspective of the art critic Adolf Behne. This argument goes further and proposes that Behne’s official history of Glashaus is possibly fabricated propaganda. So, if indeed the official history of the Glashaus is questionable, then too are the natural metaphors commonly applied to the building. By revisiting Bruno Taut’s pre-1915 writings, this investigation reveals that botanic metaphors appear to have been Taut’s primary source of inspiration for the design of the Glashaus. Through the exposure of this fact, this research contributes significantly to the current debates surrounding Bruno Taut, the Glashaus and the re-evaluation of the official histories of the modern movement
A novel mutation in the Surf1 gene in a child with leigh disease, peripheral neuropathy, and cytochrome-c oxidase deficiency
No full textWe report a 16-month-old boy with psychomotor regression, muscle hypotonia, peripheral neuropathy, and lactic acidosis. Brain magnetic resonance imaging showed a bilateral abnormal signal in the substantia nigra and in the subthalamic nucleus, suggestive of Leigh disease. Histochemical analysis of skeletal muscle showed decreased cytochrome-c oxidase activity. Biochemical analysis of respiratory chain enzymes in muscle homogenate and in cultured fibroblasts showed isolated cytochrome-c oxidase deficiency. Western blot analysis in fibroblasts showed the absence of Surf1 protein. Genetic analysis of the SURF1 gene revealed that the patient was compound heterozygous for a previously reported mutation at the splice-junction site of intron 3 (240 + 1G > T), and for a novel 4-bp deletion in exon 6 (5314delAAAT). Our data further enlarge the spectrum of mutations in SURF1 gene in patients with Leigh disease and cytochrome-c oxidase deficiency, contributing to better characterization of the clinical and neuroradiologic features of this group of patients for genotype-phenotype correlations
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