196,618 research outputs found
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
No full text11 páginas, 8 figuras, 2 tablas.-- et al.Germline activation of H-RAS oncogenes is the primary cause of Costello syndrome (CS), a neuro-cardio-facio-cutaneous developmental syndrome. Here we describe the generation of a mouse model of CS by introduction of an oncogenic Gly12Val mutation in the mouse H-Ras locus using homologous recombination in ES cells. Germline expression of the endogenous H-RasG12V oncogene, even in homozygosis, resulted in hyperplasia of the mammary gland. However, development of tumors in these mice was rare. H-RasG12V mutant mice closely phenocopied some of the abnormalities observed in patients with CS, including facial dysmorphia and cardiomyopathies. These mice also displayed alterations in the homeostasis of the cardiovascular system, including development of systemic hypertension, extensive vascular remodeling, and fibrosis in both the heart and the kidneys. This phenotype was age dependent and was a consequence of the abnormal upregulation of the renin-Ang II system. Treatment with captopril, an inhibitor of Ang II biosynthesis, prevented development of the hypertension condition, vascular remodeling, and heart and kidney fibrosis. In addition, it partially alleviated the observed cardiomyopathies. These mice should help in elucidating the etiology of CS symptoms, identifying additional defects, and evaluating potential therapeutic strategies.This work was supported by grants from the Spanish Ministry of Education and Science to M. Barbacid (SAF2003-05172 and SAF2004-20477-E) and X.R. Bustelo (SAF2006-01789); from the VI Framework Programme of the European Union to M. Barbacid (LSHC-CT-2004-503438, LSHG-CT-2007-037665, and LSHGCT-2006-037188); from the National Cancer Institute, NIH, to X.R. Bustelo (5R01-CA73735-10); from the Fondo de Investigación Sanitaria to C. Guerra (PI042124); from the Red Temática de Investigación Cooperativa en Cáncer, Instituto de Salud Carlos III, to X.R. Bustelo (RD06/0020/0001); from the Autonomous Community of Madrid to M. Barbacid (GR/SAL/0587/2004) and C. Guerra (GR/SAL/0349/2004); from the Autonomous Government of Castilla-León to X.R. Bustelo (SA053A05); and from the Fundación de la Mutua Madrileña de Automóviles to M. Barbacid. All Spanish funding to X.R. Bustelo is cosponsored by the European Union FEDER program. A.J. Schuhmacher is supported by a FPU fellowship from the Spanish Ministerio de Educación y Ciencia (MEC). V. Sauzeau is partially supported by a Juan de la Cierva postdoctoral contract from the MEC.Peer Reviewe
Evaluation of GEAPs
No full textYesEvaluation of GEAPs with Dr Maria Bustelo and Dr Julia Espinosa Fajardo at the GENOVATE conference.FP
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Technical and economic study of two repowered wind farms in Bustelo and San Xoán, 24.7 MW and 15.84 MW respectively
No full textThis study describes the technical and economic aspects of the repowering process for the wind farms in Bustelo and S. Xoán, situated in the municipalities of Muras (Lugo) and As Pontes de García Rodríguez (A Coruña), Galicia, North-Western Spain. This process was the result of a growing demand for renewable energies, facilitated by the great potential of wind energy for Galicia . Both farms were set up in 1998. The other factors they have in common - the same type of machinery, their location and a shared substation- mean they can be studied together and independently
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
No full textFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
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