1,412 research outputs found
WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Characterization of water and wildlife strains as a subgroup of Campylobacter jejuni using DNA microarrays.
No full textCampylobacter jejuni is the leading cause of human bacterial gastroenteritis worldwide, but source attribution of the organism is difficult. Previously, DNA microarrays were used to investigate isolate source, which suggested a non-livestock source of infection. In this study we analysed the genome content of 162 clinical, livestock and water and wildlife (WW) associated isolates combined with the previous study. Isolates were grouped by genotypes into nine clusters (C1 to C9). Multilocus sequence typing (MLST) data demonstrated that livestock associated clonal complexes dominated clusters C1-C6. The majority of WW isolates were present in the C9 cluster. Analysis of previously reported genomic variable regions demonstrated that these regions were linked to specific clusters. Two novel variable regions were identified. A six gene multiplex PCR (mPCR) assay, designed to effectively differentiated strains into clusters, was validated with 30 isolates. A further five WW isolates were tested by mPCR and were assigned to the C7-C9 group of clusters. The predictive mPCR test could be used to indicate if a clinical case has come from domesticated or WW sources. Our findings provide further evidence that WW C. jejuni subtypes show niche adaptation and may be important in causing human infection
Search for Higgs boson pairs decaying to WW*WW*, WW*ττ, and ττττ in proton-proton collisions at = 13 TeV
No full textThe results of a search for Higgs boson pair (HH) production in the WW*WW*, WW*ττ, and ττττ decay modes are presented. The search uses 138 fb−1 of proton-proton collision data recorded by the CMS experiment at the LHC at a center-of-mass energy of 13 TeV from 2016 to 2018. Analyzed events contain two, three, or four reconstructed leptons, including electrons, muons, and hadronically decaying tau leptons. No evidence for a signal is found in the data. Upper limits are set on the cross section for nonresonant HH production, as well as resonant production in which a new heavy particle decays to a pair of Higgs bosons. For nonresonant production, the observed (expected) upper limit on the cross section at 95% confidence level (CL) is 21.3 (19.4) times the standard model (SM) prediction. The observed (expected) ratio of the trilinear Higgs boson self-coupling to its value in the SM is constrained to be within the interval −6.9 to 11.1 (−6.9 to 11.7) at 95% CL, and limits are set on a variety of new-physics models using an effective field theory approach. The observed (expected) limits on the cross section for resonant HH production range from 0.18 to 0.90 (0.08 to 1.06) pb at 95% CL for new heavy-particle masses in the range 250–1000 GeV. © The Author(s) 2023.T
Reinermann, Mary (Death, 1906-08-10)
No full textAddress: 1523 Linn St.Age at death: 78 yrs181/Pg 103/1906/F WW/Germany/Dr. F. W. Solar/Busse & Brogman/St. Josephs OldOriginal record filed in drawer labeled 'REIK-REMY'
Des Lourier, Hattie (Death, 1901-01-30)
No full textAddress: City Hospital- 1536 Bremen St.Age at death: 665/Pg. 12/1901/F WW/Ky./Dr. George P. Dale/Busse & Borgmann/Spring Grove Cem.Original record filed in drawer labeled 'DELM-DEW'
Rise and fall of SARS-CoV-2 variants in Rotterdam: Comparison of wastewater and clinical surveillance
No full textMonitoring of SARS-CoV-2 in wastewater (WW) is a promising tool for epidemiological surveillance, correlating not only viral RNA levels with the infection dynamics within the population, but also to viral diversity. However, the complex mixture of viral lineages in WW samples makes tracking of specific variants or lineages circulating in the population a challenging task. We sequenced sewage samples of 9 WW-catchment areas within the city of Rotterdam, used specific signature mutations from individual SARS-CoV-2 lineages to estimate their relative abundances in WW and compared them against those observed in clinical genomic surveillance of infected individuals between September 2020 and December 2021. We showed that especially for dominant lineages, the median of the frequencies of signature mutations coincides with the occurrence of those lineages in Rotterdam's clinical genomic surveillance. This, along with digital droplet RT-PCR targeting signature mutations of specific variants of concern (VOCs), showed that several VOCs emerged, became dominant and were replaced by the next VOC in Rotterdam at different time points during the study. In addition, single nucleotide variant (SNV) analysis provided evidence that spatio-temporal clusters can also be discerned from WW samples. We were able to detect specific SNVs in sewage, including one resulting in the Q183H amino acid change in the Spike gene, that was not captured by clinical genomic surveillance. Our results highlight the potential use of WW samples for genomic surveillance, increasing the set of epidemiological tools to monitor SARS-CoV-2 diversity.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Sanitary Engineerin
Menke, Mary Anna (Death, 1908-11-03)
No full textAddress: 1025 Freeman AvenueAge at death: 67 yrs.62/Pg.131/1908/F WW/B.P.- Germany/Dr. Francis F. Kramer/Busse & Borgmann/St. Joseph Old Cem.Original record filed in drawer labeled 'MEIFERT-MER'
Bartley, Daniel (Death, 1902-10-16)
No full textAddress: 3003 Falke St.Age at death: 86 yrs.Pg 97/1902/197/M WW/Ireland/Dr. Isaac C. Miller/Busse & Borgman/St. Joseph's NewOriginal record filed in drawer labeled 'BARRETT-BATES'
Klopp, Michael (Death, 1903-03-29)
No full textAddress: 933 Hopkins St.Age at death: 83 yrs.Pg 35/1903/639/M WW/Germany/Dr. N.W .Abbott/Busse & Borgmann/St. Joseph's OldOriginal record filed in drawer labeled 'KLOE-KNIPPER'
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