379 research outputs found
Stephane Mallarme: A synthesis of romanticism and parnassianism, 1970
No full textThe purpose of this paper is to analyse works of Stephane Mallarme, father of Symbolism, pointing out romantic and parnassian elements. Symbolism, like Romanticism, attempted to express the interior thoughts of man. The symbolist movement then, was not only a revolt against Parnassianism but also a return to Romanticism. On the other hand, one would not be incorrect in saying that Romanticism reached its culmination in the works of the symbolists poets. For this reason, an attempt will be made to show that the works of Mallarme, father of Symbolism, can be considered as a synthesis of Romanticism and Parnassianism. This thesis contains three chapters. The first chapter is devoted to a discussion of Romanticism and of Parnassianism. Special attention is given to the origin, development, characteristics and influences of each school. The relationship of one School with the other is also pointed out. The second chapter consists of a biographical sketch of Stephane Mallarme. Special emphasis is placed on factors and events in his life which may have influenced or determined the elements of Romanticism and Parnassianism in his poetry. The third chapter is devoted to an analysis of some of the poems of Stephane Mallarme", "Les Fenetres," V Apparition," "L'Azur," "Toast Funebre," "Le Vierge," "L'Apres-Midi d'un Faune." In these analyses special attention is given to the romantic and parnassian tendencies of the poems. Since these romantic-parnaassian elements occur frequently throughout his works, it has been concluded that Mallarme's poetry can be considered as a synthesis of the two poetic schools
Obama's visit to Korea : an unwavering US-ROC alliance amidst regional tensions
No full textFor more about the East-West Center, see http://www.eastwestcenter.org/Stephane Mot, Independent Author and Blogger living in Seoul, explains that "Obama's visit did not change the opinion of the vast majority of South Koreans who consider the US-ROK alliance to be unequal, but it did further confirm the importance of South Korea for US engagement towards Asia.
MISE AU POINT D'UNE NOUVELLE STRATEGIE POUR LE DIAGNOSTIC MOLECULAIRE DE LA POLYKYSTOSE RENALE AUTOSOMIQUE DOMINANTE ASSOCIEE A PKD1 (DES NEPHROLOGIE)
No full textAIX-MARSEILLE2-BU Méd/Odontol. (130552103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Volume plaquettaire moyen et dysfonction de la fistule artério-veineuse dans une cohorte prospective de patients hémodialysés chroniques
No full textThèse présentée sous la forme d'une" thèse article"Introduction: Arteriovenous fistula (AVF) is the vascular access of 78% of haemodialysis patients in France. AVF dysfunctions such as thrombosis or stenosis are common complications. They are responsible for 30% of hospitalizations of chronic haemodialysis patients. One of the main factors behind these dysfunctions is an abnormality of hyperactive platelet-dependent coagulation during chronic renal failure. The more excitable young platelets are larger. Mean platelet volume (MPV) is a risk marker for major cardiovascular events.Objectives: Prospectively study MPV in our cohort of chronic haemodialysis as predictive marker of AVF dysfunction (occurrence of stenosis and acute thrombosis). We will study the mortality, the occurrence of cardiovascular events and serious haemorrhagic events.Materials and methods: The study included all chronic haemodialysis patients from the Conception Hospital at the CHU of Marseille between June 2014 and June 2016, component 226 patients. The main objective was to observe if there is a difference in the incidence of events on the AVF as dependent of the MPV. The population was divided according to 4 MPV levels determined by MPV quartiles in our cohort. The primary endpoint is a composite element called " AVF event" grouping: AVF acute thrombosis and AVF dysfunction requiring fistulography with endovascular treatment. Statistical analysis was done univarially by a Kaplan-Meier survival model and multivariate by a COX modelResults: 193 patients were included in the study with a median follow-up of 620 days. The median VPM was 10.8 fl [7.8-13.5] and the following quartiles: group 1: VPM ≤ 10fl, group 2: 10.1fl ≤ VPM <10.7fl, group 3: 10.7fl ≤ VPM <11, 5fl, group 4: VPM ≥ 11.5 fl. There was no difference in the characteristics of these 4 groups. There was a higher incidence (p = 0.001) in group 4 with 23 events (59%), 14 (34%) in group 3, 11 (27%) in group 2 and 6 (18%) in group 1. The multivariate analysis shows an independent association between the MPV and the risk of occurrence of an event, the OR is 1.66 [1.24-2.23] p = 0.0007. There was no significant difference in mortality, occurrence of cardiovascular events or serious bleeding events.Conclusion: We have shown in our cohort of chronic haemodialysis that the risk of occurrence of an event on arteriovenous fistula (dysfunction requiring the realization of fistulography or acute thrombosis) is predicted by measuring the MPV. It thus makes it possible to identify the patients at risk of events on the AVF. This population could benefit from enhanced surveillance or anti-aggregating or anticoagulant therapies. Limiting the number of events on the AVF would reduce the occurrence of thrombosis or even loss of vascular access exposing the patient to a vital risk.Introduction : la fistule artérioveineuse (FAV) est la voie d’abord vasculaire de 78% des patients en hémodialyse en France. Les dysfonctions de la FAV à type de thrombose ou de sténose sont des complications fréquentes. Elles sont responsables de 30% des hospitalisations des hémodialysés chroniques. Un des principaux facteurs à l’origine de ces dysfonctions est une anomalie de la coagulation dépendante des plaquettes hyperactives au cours de l’insuffisance rénale chronique. Les plaquettes jeunes plus excitables sont de plus grande taille. Le volume plaquettaire moyen (VPM) est un marqueur de risque d’événements cardiovasculaires majeurs. Objectifs : étudier prospectivement le VPM dans notre cohorte d’hémodialysés chronique comme marqueur prédictif de dysfonction de la FAV (survenue de sténose et de thrombose aiguë). Nous étudierons la mortalité, la survenue d’événements cardio-vasculaires et d’événements hémorragiques graves.Matériels et méthodes : l’étude inclus l’ensemble des patients hémodialysés chronique de l’hôpital de la Conception au CHU de Marseille entre Juin 2014 et Juin 2016, soit 226 patients. L’objectif principal était d’observer s’il existe une différence d’incidence des évènements sur la FAV en fonction du VPM. La population était divisée selon 4 niveau de VPM déterminés selon les quartiles du VPM dans notre cohorte. Le critère de jugement principal est un élément composite dénommé « évènement de FAV » regroupant : thrombose aigue de FAV et dysfonction de FAV ayant nécessité une fistulographie avec traitement endovasculaire. L’analyse statistique a été faite de façon univariée par un modèle de survie Kaplan-Meier et de façon multivariée par un modèle de COXRésultats : 193 patients ont été inclus dans l’étude avec une médiane de suivi de 620 jours. Le VPM moyen était de 10,8 fl [7.8-13.5] et les quartiles suivants : groupe 1 : VPM ≤ 10fl, groupe 2 : 10,1fl ≤ VPM < 10,7fl, groupe 3 : 10,7fl ≤ VPM < 11,5fl, groupe 4 : VPM ≥ 11,5fl. Il n’existait pas de différence concernant les caractéristiques de ces 4 groupes. On note une incidence plus grande (p=0,001) dans le groupe 4 avec 23 évènements (59%), 14 (34%) dans le groupe 3, 11 (27%) dans le groupe 2 et 6 (18%) dans le groupe 1. L’analyse multivariée montre une association indépendante entre le VPM et le risque de survenue d’un événement, l’OR est de 1,66 [1,24-2,23] p=0.0007. Il n’existait pas de différence significative concernant la mortalité, la survenue d’événements cardio-vasculaires ou d’événements hémorragiques graves.Conclusion : nous avons montré dans notre cohorte d’hémodialysés chronique que le risque de survenue d’un évènement sur fistule artérioveineuse (dysfonction nécessitant la réalisation d’une fistulographie ou thrombose aigue) est prédit par la mesure du VPM. Il permet ainsi d’identifier les patients à risque d’évènements sur la FAV. Cette population à risque pourrait bénéficier d’une surveillance renforcée voir de thérapeutiques antiagrégantes ou anticoagulantes. Limiter le nombre d’évènements sur la FAV permettrait de réduire la survenue de thromboses voire de perte de l’accès vasculaire exposant le patient à un risque vital
The Quest for Citations: Drivers of Article Impact
No full textWhy do some articles become building blocks for future scholars, while many others remain unnoticed? We aim to answer this question by contrasting, synthesizing and simultaneously testing three scientometric perspectives – universalism, social constructivism and presentation – on the influence of article and author characteristics on article citations. To do so, we study all articles published in a sample of five major journals in marketing from 1990 to 2002 that are central to the discipline. We count the number of citations each of these articles has received and regress this count on an extensive set of characteristics of the article (i.e. article quality, article domain, title length, the use of attention grabbers and expositional clarity), and the author (i.e. author visibility and author personal promotion). We find that the number of citations an article in the marketing discipline receives, depends upon “what one says†(quality and domain), on “who says it†(author visibility and personal promotion) and not so much on “how one says it†(title length, the use of attention grabbers, and expositional clarity). Our insights contribute to the marketing literature and are relevant to scientific stakeholders, such as the management of scientific journals and individual academic scholars, as they strive to maximize citations. They are also relevant to marketing practitioners. They inform practitioners on characteristics of the academic journals in marketing and their relevance to decisions they face. On the other hand, they also raise challenges towards making our journals accessible and relevant to marketing practitioners: (1) authors visible to academics are not necessarily visible to practitioners; (2) the readability of an article may hurt academic credibility and impact, while it may be instrumental in influencing practitioners; (3) it remains questionable whether articles that academics assess to be of high quality are also managerially relevant.Impact;Citation Analysis;Referencing;Scientometrics;Cite
Modeling Process of a Third Dimension Universe for Transportation Simulation: Application to Railway System
No full textIn past years, 3D models of virtual worlds have been used in several applications such as urban planning, simulation and design. In the railway field, that we chose as a field of application to illustrate our proposals in this article, simulation makes sense because of the complexity involved and the risk for personnel during upstream phases of validation. To be able to simulation with enough precision, the model of the virtual universe is a key point. Especially For train component simulation, an accurate and detailed model of the train component is mandatory. For training the drivers within a serious game, a high visual quality is required. Obtaining a single model supporting these two constraints at the same time at the lowest cost is still an open issue and involved many actors. Our contribution is a methodology and a process for creating a virtual universe model, based on automatic model generation, in order to allow the creation of large-scale universes while guaranteeing a level of details appropriate to the need, a model of constant quality and including semantic data necessary for simulation, while reducing the modeling costs and the modeling duration. The proposed process is applied to train simulation.Part of this work carried out under the ASTRES project supported by the Alstom Transport Company. The views and conclusions contained within this document are those of the authors, and should not be interpreted as representing the official policies, either expressed or implied, of the Alstom Transport Company.Galland, S (reprint author), Univ Bourgogne Franche Comte, UTBM, LE2I, Multiagent Grp, F-90010 Belfort, France.
[email protected]
The discovery of SycO reveals a new function for type three secretion effector chaperones
No full textThe Type Three Secretion (T3S) system is a device used by many Gram-negative pathogens that allows bacteria to deliver effector proteins straight into the eukaryotic cell cytosol. These effectors interfere with various signaling pathways to subvert the host cell functions. The secretion machinery of the T3S system consist of a basal body spanning the bacterial inner and outer membrane followed by a stiff hollow needle outside the bacterium. The fully assembled secretion apparatus constitute a continuous hollow conduit that connects the bacteria to the eukaryotic target cell. After cell contact, virulence proteins -called effectors- are injected directly into the cytosol of the host cell via the T3S apparatus. Several effectors of the T3S system require the assistance of specific cytosolic chaperones to be efficiently exported. There are three classes of T3S chaperones. Effector proteins are assisted by Class I chaperones. Although Class I chaperones are well characterized, their main function is still a matter of controversy. In this thesis, we demonstrate that orf155 encodes a specific chaperone for the effector YopO that we called SycO. We showed that SycO enhances YopO secretion in vitro and is required for translocation of YopO into infected cells. By pulldown assay we demonstrated that residues 20 to 77 of YopO are required and sufficient for SycO binding. Using crosslinking experiments and size exclusion chromatography analysis, we determined the stoichiometry of purified SycO and YopO-SycO complexes. SycO alone forms dimers in solution and the YopO-SycO complex has a 1:2 stoichiometry. These results suggested that SycO is a typical chaperone of the Class I. YopO is a serine/theronine kinase that interacts with Rho and Rac and disrupts the cytoskeleton of the target cells. YopO has been shown to localize at the cell plasma-membrane. By transfection of YopO-EGFP hybrid proteins into HEK293T cells, we demonstrated that the chaperone-binding domain (CBD) coincides with the membrane localization domain of YopO. Nevertheless, the CBD was not needed for the kinase activity of YopO. By ultracentrifugation, we also showed that the CBD causes YopO aggregation in the bacteria, when SycO does not cover it. Further, we show that the CBD of YopE and YopT also caused aggregation in the bacteria in the absence of SycE and SycT respectively. YopE, YopT and T3S effectors in other systems also act at the membrane of the eukaryotic host cell. We propose a new hypothesis concerning the role of T3S chaperones. The sub-cellular localization domain of effectors is aggregation-prone and creates the need for a chaperone inside bacteria. We propose that masking such aggregation-prone localization domains may be a general function for type III effector chaperones
Modeling Process of a Third Dimension Universe for Transportation Simulation: Application to Railway System
No full textIn past years, 3D models of virtual worlds have been used in several applications such as urban planning, simulation and design. In the railway field, that we chose as a field of application to illustrate our proposals in this article, simulation makes sense because of the complexity involved and the risk for personnel during upstream phases of validation. To be able to simulation with enough precision, the model of the virtual universe is a key point. Especially For train component simulation, an accurate and detailed model of the train component is mandatory. For training the drivers within a serious game, a high visual quality is required. Obtaining a single model supporting these two constraints at the same time at the lowest cost is still an open issue and involved many actors. Our contribution is a methodology and a process for creating a virtual universe model, based on automatic model generation, in order to allow the creation of large-scale universes while guaranteeing a level of details appropriate to the need, a model of constant quality and including semantic data necessary for simulation, while reducing the modeling costs and the modeling duration. The proposed process is applied to train simulation.Part of this work carried out under the ASTRES project supported by the Alstom Transport Company. The views and conclusions contained within this document are those of the authors, and should not be interpreted as representing the official policies, either expressed or implied, of the Alstom Transport Company.Galland, S (reprint author), Univ Bourgogne Franche Comte, UTBM, LE2I, Multiagent Grp, F-90010 Belfort, France.
[email protected]
Barnett's resolution of the Minkowski – Abraham dilemma holds, no 4-vector issue
No full text<p><i>There has been a century long controversy about the momentum density of photons in a medium, with two models getting experimental confirmation: the Minkowski model and the Abraham model. The latter being experimentations targeting the particle aspects of light, while the former focuses on its wave aspects. </i></p><p><i>In 2010, Barnett proposed a simple resolution to the dilemma: both approaches are correct models, but one needs to distinguish what the momentum densities represent. The model is elegant and consistent with Maxwell's equations in a medium. </i></p><p><i>Subsequently, Changbiao Wang published two papers arguing that the reasoning is incorrect because the Abraham light momentum in the medium would not be a 4-vector. This paper shows that such a view is incorrect: the author incorrectly sets the kinetic momentum density of the medium to zero. </i></p><p><i>Finally, we point out another paper that explains that the controversy is a relativistic effect between the reference frame in proper time for the wave and external observers.</i></p><p>Cite as: Stephane H Maes, (2023), "Barnett's resolution of the Minkowski – Abraham dilemma holds, no 4-vector issue", <a href="https://zenodo.org/records/10071847">https://zenodo.org/records/10071847</a>, <a href="https://shmaes.wordpress.com/2023/08/11/barnetts-resolution-of-the-minkowski-abraham-dilemma-holds-no-4-vector-issue/">https://shmaes.wordpress.com/2023/08/11/barnetts-resolution-of-the-minkowski-abraham-dilemma-holds-no-4-vector-issue/</a>, August 13, 2023</p>
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