112,476 research outputs found
Effect of prothrombin 19911 A>G polymorphism on the risk of cerebralsinus-venous thrombosis.
No full textEur J Neurol. 2010 Dec;17(12):1482-5.
Effect of prothrombin 19911 A>G polymorphism on the risk of cerebral
sinus-venous thrombosis.
Martinelli I, Bucciarelli P, De Stefano V, Passamonti SM, Menegatti M, Tormene D,
Tosetto A, Mannucci PM.
A. Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Internal
Medicine and Medical Specialties, Fondazione IRCCS Ca' Granda - Ospedale Maggiore
Policlinico, University of Milan, Milan, Italy. [email protected]
BACKGROUND AND PURPOSE: The A>G polymorphism at position 19911 of the prothrombin
gene is associated with a mildly increased risk of venous thromboembolism, alone
or in association with such common thrombophilia mutations as factor V Leiden and
prothrombin 20210 GA. Its role in cerebral sinus-venous thrombosis (CSVT) is not
known.
METHODS: The presence of prothrombin 19911 A>G was investigated in a case–control
study of 107 patients with cerebral thrombosis and factor V Leiden (n = 25),
prothrombin 20210 GA (n = 47), without known thrombophilia (n = 35) and 842
healthy individuals with the corresponding coagulation profile.
RESULTS: Prothrombin 19911 A>G did not increase the risk of CSVT in carriers of
factor V Leiden (adjusted odds ratio 1.6, 95%CI 0.6–4.7), prothrombin 20210 GA
(odds ratio 1.1, 95%CI 0.6–2.2), nor in patients without known thrombophilia
(odds ratio 1.3, 95%CI 0.5–3.1).
CONCLUSIONS: Prothrombin 19911 A>G polymorphism does not appear to be a risk
factor for CSVT, alone or in association with factor V Leiden or prothrombin
20210GA.
© 2010 The Author(s). European Journal of Neurology © 2010 EFNS.
PMID: 20482605 [PubMed - indexed for MEDLINE
Teaching gender medicine can enhance the quality of healthcare
No full textTeaching gender and sex differences is fundamental in medical classes because it has a strong impact in reducing disparity in treatment, in defining effective and personalized therapies that respect the different physiology and pathophysiology of women. Furthermore, it is the prerequisite for the pharmacoequity
Coinheritance of the HR2 haplotype in the factor V gene confers an increased risk of venous thromboembolism to carriers of factor V R506Q (Factor V leiden)
No full textWith the aim Of establishing whether the HR2 haplotype in factor V affects the risk of venous thromboembolism, a retrospective multicenter cohort study was performed in 810 family members identified through 174 probands who suffered from at least 1 episode of deep vein thrombosis and/or pulmonary embolism and had an inherited defect associated with thrombophilia (antithrombin, protein C, or protein S deficiency; factor V R506Q or prothrombin G20210A). Fifty-eight percent (468/810) of the family members had an inherited defect and 10% (47/468) were symptomatic. The HR2 haplotype was found in association with factor V R506Q more frequently in family members with venous thromboembolism (18%) than in those without (8%). Double heterozygosity for factor V R506Q and HR2 conferred a 3- to 4-fold increase in the relative risk of venous thromboambolism compared with factor V R506Q alone. The median age at first event was lower when the 2 defects were associated (46 v 52 years). No increase in risk of venous thromboembolism could be demonstrated when the HR2 haplotype was associated with inherited thrombophilic defects other than factor V R506Q. Because both factor V R506Q and the HR2 haplotype are very frequent, the effect of their coinheritance on the risk of venous thromboembolism might represent a clinically relevant issue, and screening for HR2 in carders of factor V R506Q should be considered
Risorse linguistiche per la generazione automatica della lingua dei segni naturali
No full textIl paper si sofferma sulla tematica della “Technology Training”: blended teaching supportati da Technological tools . Punto di forza delle disamine saranno le descrizioni dei progetti e prodotti di ricerca, che evidenziano le potenzialità cognitive e glottodidattiche degli strumenti tecnologici utilizzati dal Centro di Didattica delle Lingue dell'Università “Ca' Foscari” di Venezia. Il punto di partenza sono le glottotecnologie di un corpus, intese come strumento di analisi, di traduzione e di formulazione testo della lingua, sia per l’uso della lingua comune che per un determinato tipo di Fachsprache. Si giunge alla descrizione delle diverse modalità per acquisire o ampliare le competenze per la stesura di testi specialisti e a sviluppare risorse linguistiche di grande copertura quali software NLG reali. Si pone, poi, attenzione alle applicazioni e alle risorse linguistiche "neutrali" (dizionari, morfologia, struttura delle frasi e grammatiche di trasformazione), che possono essere utilizzate sia per analizzare e generare automaticamente i testi INLG 2017, quale l’Acro-Word (2014), un software plurifunzionale, che sostituisce il foglio cartaceo e che, supportato dall’uomo, produce diverse tipologie testuali in parafrasi e a testo libero
Relationship between asymmetric dimethylarginine and asymptomatic carotid atherosclerosis.
No full textAssessment of right ventricular function in advanced heart failure with nonischemic dilated cardiomyopathy: insights of right ventricular elastance
No full textBACKGROUND: The right ventriculoarterial coupling (R-V/A), a measure of right ventricular systolic dysfunction (RVSD) adaptation/maladaptation to chronic overload, and consequent pulmonary hypertension, has been little investigated in nonischemic dilated cardiomyopathy (NIDCM). We examined the correlates of R-V/A and traditional echocardiographic indices of RVSD, over the spectrum of pulmonary hypertension and tertiles of mean pulmonary artery pressures (PAPm). METHODS: In 2016-2017, we studied 81 consecutive patients for heart transplant/advanced heart failure. Inclusion criteria were NIDCM, reduced ejection fraction (≤40%) and sinus rhythm. R-V/A was computed as the RV/pulmonary elastances ratio (R-Elv/P-Ea), derived from a combined right heart catheterization/transthoracic- echocardiographic assessment [right heart catheterization/transthoracic-echocardiographic (RHC/TTE)]. RESULTS: A total of 68 patients (mean age 64 ± 7 years, 82% men) were eligible. After adjustments, R-Elv and P-Ea were higher in isolated postcapillary-pulmonary hypertension (Ipc-PH) than combined-pulmonary hypertension (Cpc-PH) (P = 0.004 and P = 0.002, respectively), whereas R-V/A progressively decreased over Ipc-PH and Cpc-PH (P = 0.006). According to PAPm increment, P-Ea congruently increased (P-Trend = 0.028), R-Elv progressively decreased (P-Trend<0.00)1, whereas R-V/A significantly worsened (P-Trend = 0.045). At the multivariable analysis, a reduced RV longitudinal function (TAPSE<17 mm) was positively associated with R-V/A impairment (<0.8) [odds ratio 1.41, 95% confidence interval (CI) (1.07--1.87), P = 0.015]. R-Elv and P-Ea showed good interobserver reliability [interclass correlation (ICC) 0.84, 95% CI (0.32--0.99), P = 0.012 and ICC 0.98, 95% CI (0.93--99), P < 0.001, respectively]. CONCLUSION: Among NIDCM HF patients, in a small cohort study, RHC/TTE-derived R-V/A assessment demonstrated good correlations with pulmonary hypertension types and RV functional status. These data suggest that R-V/A encloses comprehensive information of the whole cardiopulmonary efficiency, better clarifying the amount of RVSD, with good reliability
author-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism
No full textHypercoagulability due to high coagulation factors XI, VIII, IX, II, and fibrinogen is recognized as a risk factor of venous thromboembolism (VTE). These factors are cumulatively explored by the activated partial thromboplastin time (APTT). To test the hypothesis that a short APTT increases the risk of VTE, a case-control study was carried out in 605 patients referred for thrombophilia testing after documented VTE and in 1290 controls. Median APTT ratio (coagulation time of test-to-reference plasma) values were 0.97 (range: 0.75-1.41) for patients and 1.00 (range: 0.72-1.33) for controls (P < .001). In patients who had an APTT ratio smaller than the fifth percentile of the distribution in controls, the odds ratio (OR) for VTE was 2.4 (95% confidence interval [CI]: 1.7-3.6) and was independent of inherited thrombophilic abnormalities. Further statistical analyses in 193 patients and 259 controls for whom factor VIII (FVIII) levels were available showed a decrease of the OR from 2.7 (95% CI: 1.4-5.3) to 2.1 (95% CI: 1.0-4.2), indicating that the risk was only partially mediated by high FVIII levels. In conclusion, hypercoagulability detected by a shortened APTT is independently associated with VTE. This inexpensive and simple test should be considered in the evaluation of the risk of VTE
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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