1,721,174 research outputs found
Incidence and risk factors of motor neuron disease in the venice and padua districts of italy, 1972-1979
No full text105 patients with motor neuron disease (MND) from the Provinces of Padua and Venice were evaluated over an 8-year period (1972-1979). Average annual age-adjusted incidence rates rose from 0.49/100,000/year in 1972-1973 to 0.82/100,000/year in 1978-1979. Our epidemiologic survey showed a higher incidence in sparsely populated areas (1.7/100,000/year). A case-control study of 25 patients with MND revealed a statistically significant association with previous fractures (p < 0.01). © 1983 S. Karger AG, Basel
Carnitine, carnitine acyltransferases, and rat brain function
No full textThe concentrations of free, short chain, and long chain acylcarnitines and the enzyme activities of carnitine acetyltransferase (CAT) and carnitine palmityltransferase (CPT) were studied in different rat brain regions. The fate of tritium-labeled carnitine was studied in different brain regions in vivo after i.p. injection in 3-month-old Sprague-Dawley rats. The tritium counts were particularly high in the hypothalamic region. At 24 h after hydrocortisone injection, a significant increase in counts was observed in the hypothalamus (P < 0.01). A high concentration of total carnitine was found in the hypothalamus (4.00 nmol/mg noncollagen protein) and in other regions such as the spinal cord (1.29 nmol/mg noncollagen protein), cerebellum (1.19), and olfactory tracts (0.66) carnitine concentration was much lower. Carnitine content was proportional to CPT, an inner mitochondrial enzyme. The activity of the enzyme CAT was found to be high in rat hippocampus and hypothalamus. This enzyme in brain may be involved in the transport of acyl groups outside the mitochondria and in the regulation of pyruvate utilization, contributing to acetylcholine synthesis or regulation. © 1982
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Disorders of cognitive and affective development in cerebellar malformations.
No full textAcquired cerebellar lesions in adults and children can lead to the development of a complex behavioural pattern termed 'Cerebellar Cognitive Affective Syndrome' (Schmahmann and Sherman, Brain, 1998; 121: 561-79), which is characterized by reduced cognitive efficiency associated with specific neuropsychological deficits (executive and visuospatial disorders), expressive language disorders (mild agrammatism and anomia) and affective disorders with blunting of affect. It is not known whether a symptomatological picture such as this can also be found in congenital cerebellar malformations. We studied the behavioural developmental profile of 27 patients including children and adults with congenital malformations confined to the cerebellum, the largest studied sample to date. Extensive clinical and neuropsychological investigations highlight the presence of a wide range of disorders supporting the important role played by the cerebellum in the acquisition of higher-order cognitive and affective skills. The type and extent of cerebral reorganization processes in the presence of malformative lesions are difficult to predict and may possibly account for the variability of clinical phenotypes. It is, therefore, more difficult to identify a syndromic picture defined as exactly as is the case with acquired lesions. However, the pattern of deficits that we document is in remarkable agreement with the general profile of the Cerebellar Cognitive Affective Syndrome. Malformations affecting the cerebellar vermis induce affective and social disorders and evolve towards more unfavourable pictures often associated with an autistic symptomatology. Malformations of cerebellar hemispheres are more frequently associated with selective neuropsychological deficits involving mainly executive functions and visuospatial and linguistic abilities. Motor deficits are generally less severe, and tend to improve slowly and progressively, in some cases reaching almost complete functionality. Finally, the overall favourable evolution with an onset of skills in advanced age in a consistent subset of subjects suggests that individual follow-ups should be performed in order to monitor the quality and stability of impairments and acquired abilities over time
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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