197,694 research outputs found
β-diversity of deep-sea holothurians and asteroids along a bathymetric gradient (NE Atlantic)
No full textMeasuring and understanding patterns of ?-diversity remain major challenges in community ecology. Recently, ?-diversity has been shown to consist of 2 distinct components: (1) spatial turnover and (2) species loss leading to nestedness. Both components structure deep-sea macrofaunal assemblages but vary in importance among taxa and ocean basins and with energy availability. Here, we present the first evidence for turnover and nestedness along a bathymetric gradient in 2 major megafaunal taxa, holothurians and asteroids. Turnover is the dominant component of ?-diversity throughout bathyal and abyssal zones in both taxa, despite major differences in ?-diversity and trophic composition. High spatial turnover suggests a role for evolutionary adaptation to environmental circumstances within depth bands. This pattern differs fundamentally from those in some macrofaunal groups in low-energy environments where abyssal nestedness is high and diversity low, with diversity maintained partly by source-sink dynamics
Christine de Suède , drame historique en cinq actes et en vers, par M. L. Brault. Représenté pour la première fois sur le Théâtre-français, le 25 juin 1829, précédé de la Relation de la mort du marquis de Monaldeschi écrite par le P. Lebel, seul témoin de cette exécution
No full textComprend : Relation de la mort du marquis de MonaldeschiAvec mode text
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
No full textFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
Infirmière-chef : acteur clé pour assurer la qualité et la sécurité des soins
No full textRapport de stage présenté à la Faculté des sciences infirmières en vue de l'obtention du grade de Maître ès sciences (M. Sc.) en sciences infirmières option administration des services infirmiersLes infirmières-chefs assurent le lien entre la direction et les employés, ont une influence sur la satisfaction des infirmières et veillent à l’atteinte des objectifs de l’établissement (American Nursing Association, 2009; Aroian et al., 1997; Oroviogoicoechea, 1996). Elles jouent un rôle clé pour assurer une qualité et une sécurité des soins sur l’unité (Lee & Cummings, 2008). Dans cette perspective, l’Hôpital Maisonneuve-Rosemont a entrepris de définir des orientations stratégiques visant l’amélioration de la qualité et de la sécurité des soins ainsi que des conditions de pratique et de soutien pour les infirmières-chefs afin de valoriser leur rôle au sein de l’organisation. Ce rapport rédigé sous forme d’un article présente une expérience de stage effectuée à l’Hôpital Maisonneuve-Rosemont portant sur l’intégration de la gestion de la sécurité et de la qualité des soins dans le rôle des infirmières-chefs. Des entrevues ont été réalisées avec des infirmières-chefs ayant de zéro à cinq ans d’expérience dans leur poste et avec ceux ayant plusieurs années d’expérience à titre d’infirmière-chef afin de recueillir quels pourraient être leurs besoins et le soutien souhaité afin de favoriser une bonne intégration de la notion de sécurité dans leur rôle d’infirmière-chef. Également, des membres de la direction ont été rencontrés. L’analyse des résultats a été guidée par le modèle renouvelé de la gouvernance clinique de Brault, Roy et Denis (2008). Les résultats des rencontres ont permis d’identifier deux compétences qu’ils jugent essentielles pour l’infirmière-chef et d’indiquer des avenues possibles afin de mieux les soutenir dans le développement de celles-ci
Infirmière-chef : acteur clé pour assurer la qualité et la sécurité des soins
No full textRapport de stage présenté à la Faculté des sciences infirmières en vue de l'obtention du grade de Maître ès sciences (M. Sc.) en sciences infirmières option administration des services infirmiersLes infirmières-chefs assurent le lien entre la direction et les employés, ont une influence sur la satisfaction des infirmières et veillent à l’atteinte des objectifs de l’établissement (American Nursing Association, 2009; Aroian et al., 1997; Oroviogoicoechea, 1996). Elles jouent un rôle clé pour assurer une qualité et une sécurité des soins sur l’unité (Lee & Cummings, 2008). Dans cette perspective, l’Hôpital Maisonneuve-Rosemont a entrepris de définir des orientations stratégiques visant l’amélioration de la qualité et de la sécurité des soins ainsi que des conditions de pratique et de soutien pour les infirmières-chefs afin de valoriser leur rôle au sein de l’organisation. Ce rapport rédigé sous forme d’un article présente une expérience de stage effectuée à l’Hôpital Maisonneuve-Rosemont portant sur l’intégration de la gestion de la sécurité et de la qualité des soins dans le rôle des infirmières-chefs. Des entrevues ont été réalisées avec des infirmières-chefs ayant de zéro à cinq ans d’expérience dans leur poste et avec ceux ayant plusieurs années d’expérience à titre d’infirmière-chef afin de recueillir quels pourraient être leurs besoins et le soutien souhaité afin de favoriser une bonne intégration de la notion de sécurité dans leur rôle d’infirmière-chef. Également, des membres de la direction ont été rencontrés. L’analyse des résultats a été guidée par le modèle renouvelé de la gouvernance clinique de Brault, Roy et Denis (2008). Les résultats des rencontres ont permis d’identifier deux compétences qu’ils jugent essentielles pour l’infirmière-chef et d’indiquer des avenues possibles afin de mieux les soutenir dans le développement de celles-ci
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle
No full textEffects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology Protein degradation is a major cause of skeletal muscle atrophy and is, at least in part, regulated at the level of gene transcription. While obesity is characterized by impaired skeletal muscle carbohydrate and lipid metabolism, the effects of obesity on skeletal muscle protein metabolism, specifically protein degradation, have not been thoroughly examined. Despite increased skeletal muscle mass, skeletal muscle of the severely obese overexpresses protein degradation genes, most notably, myostatin, which increases protein degradation by activating the transcription factor SMAD3, a mediator of transforming growth factor-[beta] family signaling. GOALS: The aims of the present project were: 1) to determine how obesity affects skeletal muscle protein degradation mediated by the ubiquitin-proteasome system and the autophagic/lysosomal pathway, particularly at the level of gene expression and 2) to determine the role of SMAD3 in regulating gene transcription of MuRF-1, a gene involved in degradation of contractile proteins. METHODS: In order to accomplish these goals, primary human skeletal muscle (HSkMC) myotubes from lean and severely obese women were subjected to various atrophic stimuli (100nM dexamethasone or starved of serum and amino acids) and analyzed for gene expression and flux through the major protein degradation pathways. Additionally, MuRF-1 promoter activity and RNA content were measured following co-expression of SMAD3 and FoxO3, a transcription factor known to induce MuRF-1 gene expression and cause muscle atrophy. RESULTS: Myotubes from the obese significantly overexpressed FoxO3, had a decreased rate of flux through the autophagic/lysosomal pathway, and increased proteasome capacity compared to lean. Despite these differences, myotubes from lean and obese women atrophied at similar rates and displayed similar total protein degradation rates under basal and starved conditions. Additionally, SMAD3 overexpression was insufficient to induce MuRF-1 promoter activity or gene expression, but synergistically augmented FoxO3-induced MuRF-1 gene expression by increasing FoxO3 protein content and enhancing FoxO3 binding to the proximal MuRF-1 promoter region. Furthermore, knockdown of SMAD3, via overexpression of a dominant-negative SMAD3, significantly attenuated FoxO3-induced MuRF-1 promoter activity. Mutation of the SMAD Binding Element (SBE) within the MuRF-1 promoter region attenuated FoxO3 binding to the FoxO Response Element (FRE), indicating SMAD3 is required for optimal FoxO3-induced MuRF-1 gene transcription. CONCLUSIONS: Skeletal muscle of the severely obese displays altered flux through the major protein degradation pathways, which may contribute to some of the metabolic impairments associated with obesity. However, severe obesity does not affect the total protein degradation rate or rate of muscle atrophy. Furthermore, SMAD3 regulates MuRF-1 gene transcription through dual mechanisms: 1) increasing FoxO3 protein content and 2) increasing FoxO3 binding within the proximal MuRF-1 promoter region. Atrophic conditions that increase SMAD3 transcriptional activity may augment FoxO3-induced transcription of protein degradation genes and accelerate muscle atrophy. Due to the observed overexpression of FoxO3, skeletal muscle of the severely obese may be more susceptible than that of lean persons to atrophy under conditions that increase expression and/or activity of SMAD3.Ph.D
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