30 research outputs found
Pan-immune-inflammation value could be a new marker to differentiate between vascular Behçet’s disease and non-vascular Behçet’s disease
No full textOBJECTIVE: Behçet’s disease etiology is uncertain, and no specific diagnostic markers exist in the laboratory. This retrospective study aimed to evaluate the role of inflammatory and hematological parameters, mainly Pan-Immune-Inflammation-Value (PIV), in predicting vascular Behçet’s disease (VBD). PATIENTS AND METHODS: A total of 85 patients with VBD and 92 patients without vascular involvement (non-VBD) were included in this study. Neutrophil, monocyte, platelet, and lymphocyte subsets are all included in the PIV, a new blood-based biomarker. RESULTS: The optimal cut-off values for the PIV were determined to be ≥261.6. White blood cell, neutrophil, monocyte, hemoglobin, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration (MCHC), red cell distribution, platelet, plateletcrit, PIV, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, sedimentation, c-reactive protein (CRP) values were significantly associated with VBD in univariate analysis. After multivariate analysis, PIV [odds ratio (OR): 2.758; 95% confidence interval (CI): 1.327-5.736; p=0.007] and CRP (OR: 4.029; 95% CI: 1.924-8.438; p<0.001) were found to be a positive predictor for VBD, while MCHC (OR: 0.722; 95% CI: 0.530-0.983; p=0.039) was seen as a negative predictor. CONCLUSIONS: Based on our results, PIV, an easily accessible, cost-effective, and new composite biomarker, has a significant predictive value in VBD
Evolving dynamics: analysing the global impact of China’s and India's rise on western economies and political strategies
No full textIn the course of globalization, the global balance of power has begun to shift, mainly influenced by the rapid economic rise of China and India. Economic growth, technological innovation and strategic geopolitical alignment are few of the main factors which reshape the international order. The influence of those emerging economies, mainly China and India, has begun to challenge the long-standing dominance of Western nations in areas such as trade, politics and security.
This thesis aims to investigate and evaluate the emergence of China and India as well as the reactions of the Western nations, particularly the United States and the European Union, underpinned by embedding liberal and heterodox theories of international political economy. A particular emphasis is placed on the economic development, technological advancements, currency strategies and geopolitical behavior.
To address this topic, the research focuses on the research question: How can the rise of China and India be explained, and how can the Western reactions to this shift be interpreted and evaluated?
To answer this question, the thesis combines a literature review with quantitative data analysis and case studies. Academic literature, policy reports and data from international institutions such as the World Bank and IMF provide the foundation for the analysis of this economic interdependence, strategic alliances and institutional changes.
The findings show that the emergence of China and India offers opportunities for global development and partnerships but also creates strategic tension and economic competition. Western nations are, therefore, facing the challenge to redefine their role in a multipolar world. It is evident that economic and geopolitical influence is shifting towards Asia. Whether China and India will overtake Western powers, or a more balanced global distribution remains, will be seen in the years ahead.Masterarbeit Wien, Fachhochschule des BFI Wien 202
May The Neutrophil Lymphocyte Ratio be A New Marker For Uveitis Development In Ankylosing Spondylitis?
No full textα9 β1 integrin & its ligands as new potential biomarkers in FMF
No full textBackground & objectives: Familial Mediterranean Fever (FMF) manifests as a hereditary condition characterized by repeated bouts of fever, abdominal, chest, and joint discomfort, and swelling. Colchicine is the most common form of treatment, but it does not eliminate the disease. The underlying causes of the inflammatory mechanism are still not fully known. Methods: A total of 20 healthy controls, 16 individuals with FMF in the attack period, and 14 in the remission period participated in the study. ITGA9, ITGB1, OPN, TNC, VEGF, VCAM-1, TGM2, TSP-1, Emilin-1, and vWF levels were measured by ELISA by obtaining serum from blood samples of individuals. In addition, gene expressions of α9 β1 (ITGA9, ITGB1) and its best known ligands (TNC, SPP1) were analyzed by quantitative real-time PCR (qPCR). Results: The findings of this study showed that serum levels of α9 β1 and its ligands were higher in individuals with FMF in the attack period than in the healthy controls and the FMF group in the remission period (P<0.05). The marker levels of the healthy group were also higher than those in the remission period (p<0.05). In addition, when the gene expressions were compared between the healthy controls and FMF group, no significant difference was found for ITGA9, ITGB1, TNC, and SPP1 genes. Interpretation & conclusions: The function of α9 β1 and its ligands in FMF disease was investigated for the first time in this study as per our knowledge. Serum levels of these biomarkers may help identify potential new targets for FMF disease diagnosis and treatment approaches
What predicts the recurrence in ıdiopathic granulomatous mastitis?
No full textIntroduction Idiopathic granulomatous mastitis (IGM) is a rarely seen chronic and benign disease of the breast. IGM usually emerges in women between 30 and 45 years of age and within the first 5 years after lactation. There is no consensus on the treatment of the disease. Steroids, immunosuppressive agents such as methotrexate and azathioprine, antibiotics, and surgical and conservative treatments can be preferred. In the present study, it was aimed to demonstrate the treatment options and follow-up data of the patients with IGM and to investigate the effective factors on recurrence if developed in the follow-up period.Materials and method The data of 120 patients diagnosed with idiopathic granulomatous mastitis were evaluated for this cross-sectional retrospective study. The demographic, clinical, treatment, and follow-up features of the patients were obtained from the file records.Results The median age value of the 120 female patients included in the study was 35 (24-67) years. Of the patients, 45%, 79.2%, 49.2%, and 15% had a past history of surgical intervention, steroid use, methotrexate use, and azathioprine use, respectively. Recurrent lesion developed after the treatment in 57 (47.5%) patients. The recurrence rate was 66.1% in the patients who underwent surgical intervention in the initial treatment. There was a statistically significant difference between the patients with and without recurrence regarding the presence of abscess, the presence of recurrent abscess, and having surgical intervention as the initial treatment in the past history. The rate of having surgery was statistically significantly higher compared with the administration of steroid therapy alone and the combination of steroid and immunosuppressive therapy in the initial treatment of the patients who developed recurrence. The rate of having surgery together with the administration of steroid and immunosuppressive therapy was statistically significantly higher than the administration of steroid and immunosuppressive therapies.Discussion Our study showed that surgical intervention and the presence of abscess increased recurrence in the treatment of IGM
Statistical Reasoning of Impact of Motivation on Students’ Achievement in Foreign Language Learning
No full textAbstractThis research focuses on statistical reasoning in motivation issues in learning a foreign language. The opinions of university students studying at different departments and taking a foreign language course have been investigated through 43 statements related to motivation issues in order to find out their opinions on motivation sources in general, classroom motivation sources and motivation problems that arise or they encounter during their foreign language studies. The responses of participants through all the statements were in very close line with each other, without revealing any significant difference. The relation between the participants achievement level in foreign language courses and motivation revealed contradiction as the respondents claim lack of motivation but have a achievement level over the minimum pass level. This result reveals that in terms of statistical reasoning there is a contradiction between negative motivation and positive achievement
Sudden Rupture of the Internal Maxillary Artery Causing Pseudoaneurysm (Mandibular Part) Secondary to Subcondylar Mandible Fracture
No full textThe mandible is one of the most frequently fractured bones of the face. Condylar fractures are the most common mandibular fractures in adults. The potential complications of mandibular fractures are infection, paresthesia, malunion, nonunion, asymmetry, and long-term functional and growth disturbances. In this article, we report an uncommon case of life-threatening pseudoaneurysm of the internal maxillary artery secondary to subcondylar fracture. We believe that the subcondylar fracture on the vertical vector and oblique direction can damage vital tissues such as the internal maxillary artery, and this injury was, to our knowledge, the first reported acute pseudoaneurysm, which occurred just after the injury at the initial part of the maxillary arter
Histopathologic results of long-term sildenafil administration on rat inner ear
No full textObjectives: Sildenafil, a selective inhibitor of phosphodiesterase type 5, is widely used for the treatment of erectile dysfunction. Although cochlear effects of phosphodiesterase type 5 inhibitors remain still unclear because of inadequate data, some evidence that recently emerged indicates that these medications may be responsible for hearing impairment. In the present study, we aimed to examine the histopathologic effects of long-term sildenafil use on the cochlea in a rat model. Methods: The study was performed with adult male Wistar albino rats. The control group was fed on standard laboratory diet. The study group was applied orally with sildenafil therapy, 1.5 mg/kg once a day for 45 days. Rats were anesthetized and decapitated. Each temporal bone was dissected, and the cochleas were removed en bloc. The inner-ear biopsy specimens were examined histologically with hematoxylin and eosin and caspase 3 immunoreaction under light microscopy. Results: Hematoxylin and eosin staining showed no distinctive difference between the control group and the sildenafil group. With immunohistochemical examination, caspase 3 immunoreactivity was observed in the sildenafil group. In the control group, caspase 3 immunoreactivity was not observed. Conclusions: The caspase 3 immunoreactivity in the sildenafil group was strongly associated with an increase in apoptotic events in the cochlea. Long-term use of sildenafil can cause hearing impairment through increased apoptosis. (c) 2012 Elsevier Inc. All rights reserved
Characteristic sets verses generalized characteristic sets
No full textThe notion of characteristic sets that was developed by Ritt and Wu has been turned into an usual tool for study of set/systems of polynomial equations, algebraic as well as differential equations. By constructing a characteristic sets, one can triangularize an arbitrary set/system of any type of polynomials. It ensures that it can be decomposed into triangular form of a particular set/system. In this manuscript, a comparison of characteristic sets defined by Ritt-Wu's differential is provided with the generalized characteristic sets defined by author in [5]. Comparison shows that this scheme performs better than earlier method
